[Interaction of intact and irradiated macrophages with thymus lymphoid cells]. / Vzaimodeistvie intaktnykh i obluchennykh makrofagov s limfoidnymi k;etkami timusa.

The rat broncho-alveolar macrophages, subjected to gamma-irradiation, were incubated for 4 hours with irradiated (4 Gy) thymocytes. Following the total 24 hour incubation, some morphological features of macrophages were revealed in addition to their influence on survival, autologous rosetting and mitotic index of intact thymocytes. The increase in macrophage spreading was shown which was dose-dependent in the 1 to 4 Gy scale. Enhanced viability of thymocytes was revealed in the presence of macrophages irradiated at the dose of 1-2 Gy. Addition of 24 hour cultures of intact or irradiated macrophages elicited a significant decrease in rosette-forming capacity among thymocytes. Gamma-irradiation of 2 to 4 Gy inhibited the ability of macrophages to suppress the mitotic activity of thymic cells. A possibility of postradiational modification of some specific functions and properties of macrophages, including their thymotropic effects, is discussed.

[Nucleic acid and protein synthesis in the lymphocyte populations of men, women and patients with karyotype 45,XO]. / Sintez nukleinovykh kislot i belka v populiatsiiakh limfotsitov muzhchin, zhenshchin i bol'nykh s kariotipom 45,XO.

The synthesis of DNA, RNA and protein was measured in the lymphoid cells of the palatine tonsils in children aged from 3 to 15 years. The rate of RNA synthesis was also studied in the peripheral blood lymphocytes of men and women of different age and also in the patients with Shereskevsky-Turner's syndrome. 3H-thymidine incorporation into the tonsillar lymphocytes was independent of sex. 3H-uridine incorporation both into the palatine lymphocytes and into the peripheral blood lymphocytes in persons under 20 years of age and over 50 years old was greater in males. The rate of RNA and protein synthesis in the lymphocytes with kariotype 45,XO proved to be greater than in the lymphocytes with kariotype 46,XX and 46XY. The detected differences are discussed from the aspect of sex differences of the hormonal background and dyshormonal condition in patients with Shereshevsky-Turner's syndrome and possible differences in the temporary parameters of the mitotic cycle.