ABSTRACT
Objective To analyze clinical value of carotid ultrasonic examination in hypertension,to provide a reference for clinical diagnosis and treatment.Methods 380 patients with hypertension were selected and divided into different grades according to China Hypertension Prevention Guide.All patients were diagnosed with carotid ultra-sonic examination,thick endomembrane of carotid and carotid plaques were compared in patients with different danger grades,age and course of disease.Results 273 patients were examined with carotid atherosclerosis(142 patients with IMT,131 patients with carotid plaques),positive rate was 71.84%;with dangerous situation,age and course of dis-ease increased,positive rate of examination,PSV and RI increased.Conclusion Carotid ultrasonic examination is helpful for diagnosis of hypertension and worth of applying in clinical fields.
ABSTRACT
AIM OF THE STUDY: Based on the recipe of the traditional anti-diabetic formula TZQ, we developed TZQ-F, a new formula including 8 fractions isolated from Red Paeony root, Mulberry leaf, Lotus leaf, Danshen root and Hawthorn leaf with a good quality assurance. The study was aimed at fraction preparation and effects of the fractions on abnormal glucose and lipid metabolism. MATERIALS AND METHODS: The active fractions were obtained by macroporous resin, ion-exchange resin and polyamide resin column chromatographies. HPLC analyses were used for quality control. In vitro mechanism study included DPPH radical scavenging, AGEs formation inhibition, alpha-glucosidase inhibition and lipase inhibition, and rats on high-fat diet were used for in vivo study. RESULTS: In vitro mechanism study showed that among the 8 fractions, three of them had inhibition effects on intestinal disaccharase, three with inhibition effects on lipase, and five with effects of free radical scavenging. In vivo study showed that after 4 weeks of treatment, TZQ-F significantly decreased the levels of serum total cholesterol, TG, glucose, LDL-C and HDL-C in rats on high-fat diet. Consistent with the in vitro and in vivo results, histology study demonstrated that TZQ-F alleviated hepatic steatosis induced by high-fat diet. CONCLUSIONS: TZQ-F possesses the potential regulation effects on abnormal glucose and lipid metabolism.
