ABSTRACT
OBJECTIVE: N-methyl-D-aspartate and other glutamate receptors have been shown to present on the peripheral axons of primary afferents, and peripheral injection of N-methyl-D-aspartate-receptor antagonists can suppress hyperalgesia and allodynia. Thus, this study examined postoperative analgesic and adverse effects of local ketamine administered postoperatively. METHODS: Ketamine (0.3%, 3 mL) or saline was subcutaneously infiltrated before incision in a double-blind manner using a sample population of 40 patients undergoing circumcision surgery, equally and randomly assigned to 2 groups based on the treatment. The saline-infiltrated patients also received 9-mg intramuscular ketamine into the upper arm to control for any related systemic analgesic effects. The patients were followed up for 24 hours to determine postoperative analgesia and identify adverse effects. RESULTS: In the ketamine-infiltrated patients, the time interval until first analgesic demand (166 vs. 80 min) was longer and the incidence of pain-free status (pain score=0) during movement (45% vs. 10%) and erection (40% vs. 0%) was significantly higher than for the saline-treated analogs (P<0.05). The dose of ketorolac use and pain score during erection were significant lower in group ketamine patients. No significant differences were noted with respect to the incidence of adverse effects comparing the 2 groups. DISCUSSION: We conclude that preincisional subcutaneous ketamine infiltration can suppress postoperative pain after the circumcision surgery.
Subject(s)
Analgesia, Epidural/methods , Excitatory Amino Acid Antagonists/therapeutic use , Ketamine/therapeutic use , Pain, Postoperative/drug therapy , Adolescent , Adult , Analgesia, Patient-Controlled/methods , Circumcision, Male/adverse effects , Double-Blind Method , Excitatory Amino Acid Antagonists/adverse effects , Female , Humans , Ketamine/adverse effects , Male , Pain Measurement/methods , Pain, Postoperative/etiology , Time FactorsABSTRACT
We report an 85-year-old tracheostomized male patient who underwent ventriculoperitoneal shunt because of hydrocephalus. Postoperative acute airway obstruction and tension pneumothorax developed due to the granulation tissue of tracheostoma which scraped off from the tracheostoma in the act of endotracheal intubation for operation and it lay dormant around until it was drawn into the endotracheal tube (ETT) by negative pressure during suction of trachea in intensive care unit. Persistent hypoxemia in consequence of airway obstruction resulted in cardiac arrest and expiratory seal of trachea eventuated in tension pneumothorax. Flexible fiberoptic bronchoscopy performed during resuscitation disclosed that the obstruction was due to granulation tissue which blocked the ETT lumen. Immediate exchange of endotracheal tube and placement of chest tube made the patient tide over this crisis. No sequela resulted from this crisis and the patient was discharged one week later.
