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1.
Psychiatry Investig ; 17(5): 395-402, 2020 May.
Article in English | MEDLINE | ID: mdl-32375458

ABSTRACT

OBJECTIVE: Early detection and proper management of mental illness can help to prevent severe deterioration. However, with limited financial and human resources of community mental health services, it is not practical to carry out all conventional screening tools simultaneously. In this study, we aimed to develop and validate a brief but comprehensive screening questionnaire for four common mental illnesses of the elderly. METHODS: The brief screening for four mental illnesses of elderly (BS4MI-elderly) is a 14-item binary response questionnaire that covers dementia, depressive disorder, sleep disorder, and hwa-byung. To test validity, we compared conventional scale scores for three groups of participants classified using the BS4MI-elderly. The sensitivity, specificity, predictive value of positive test, likelihood ratio of positive test and internal consistency of the BS4MI-elderly were assessed. Finally, a correlation analysis between the BS4MI-elderly and general mental health scales was conducted. RESULTS: A total of 254 participants aged over 65 years were recruited. The BS4MI-elderly showed moderate to high sensitivity for the test that distinguishes the normal group from the risk and disorder groups (dementia: 0.61, depressive disorder: 0.88, sleep disorder: 0.85, hwa-byung: 0.94) and high specificity for the test that distinguishes the disorder group from the normal and risk groups (dementia: 0.91, depressive disorder: 0.93, hwa-byung: 0.84, sleep disorder: 0.84). The BS4MI-elderly also exhibited good internal consistency and significant correlations with general mental health scales. CONCLUSION: The BS4MI-elderly, a brief but comprehensive screening tool, could be a useful instrument for screening the elderly in community mental health services.

2.
J Korean Med Sci ; 35(19): e144, 2020 May 18.
Article in English | MEDLINE | ID: mdl-32419398

ABSTRACT

BACKGROUND: Information about the factors involved in the progress of both high distressed and low distressed victims in the early days after a sexual assault are needed to provide effective intervention for victims of sexual assault. In this study, we examined the relationship among posttraumatic stress disorder (PTSD) symptoms, assault-related factors and trauma-related cognitions in Korean female victims of sexual assault. METHODS: For this study, we retrospectively investigated the records of 94 female victims from the Sunflower Center for Women and Children Victims of Violence at the Ajou University Hospital in Korea. Demographic characteristics and the features of the sexual assault, post-traumatic stress symptoms, and trauma-related cognition were obtained from data recorded at the initial assessment. One month after the initial assessment, victims were contacted by telephone and their PTSD symptom severity was re-evaluated. The sample of 94 participants were divided into two groups depending on the PTSD symptom scale scores at initial assessment: High-distress group and Low-distress group. RESULTS: Repeated-measured analyses of variance revealed that the high-distress group showed a decrease in PTSD symptom severity over the month, while the low-distress group did not show significant change of PTSD symptom severity. In correlation analysis, negative thoughts and beliefs about the assault were strongly correlated with PTSD symptom severity one month later in both the low-distress and high-distress groups. CONCLUSION: Our results suggest that trauma-related cognitions seem to play an important role in the maintenance of PTSD both of high-distress and low-distress groups, and that effective intervention will need to address these cognitive factors.


Subject(s)
Cognition/physiology , Crime Victims/psychology , Sex Offenses , Stress Disorders, Post-Traumatic/pathology , Adolescent , Adult , Female , Humans , Republic of Korea , Retrospective Studies , Severity of Illness Index , Young Adult
3.
J Interpers Violence ; 35(11-12): 2254-2270, 2020 06.
Article in English | MEDLINE | ID: mdl-29294706

ABSTRACT

Trauma-related cognitions play an important role in formation and persistence of posttraumatic stress symptoms. This study investigated the psychometric properties of the Korean version of the Posttraumatic Cognitions Inventory (PTCI) in a sample of 227 females who had experienced sexual violence. Data were collected from victims who sought victim support services following sexual violence between 2011 and 2015. The Impact of Event Scale-Revised, Beck Depression Inventory, and Beck Anxiety Inventory were used to measure posttraumatic stress disorder severity, depression, and anxiety, respectively. The three-factor solution of the PTCI (SELF, WORLD, BLAME) was supported; however, it was necessary to remove five items from the original 33-item scale. The 28-item PTCI displays good internal consistency, concurrent validity, and discriminant validity. SELF and WORLD subscales correlated with trauma symptom severity, controlling depression and anxiety. This is the first study to investigate factor structure and psychometric properties of the Korean version of the PTCI with female victims of sexual violence, which demonstrated that 28-item version of PTCI is an acceptable assessment measure of examining trauma-related cognitions.


Subject(s)
Crime Victims , Psychiatric Status Rating Scales , Sex Offenses , Stress Disorders, Post-Traumatic , Crime Victims/psychology , Crime Victims/statistics & numerical data , Factor Analysis, Statistical , Female , Humans , Psychometrics , Reproducibility of Results , Republic of Korea , Sex Offenses/psychology , Stress Disorders, Post-Traumatic/diagnosis
4.
Article in English | MEDLINE | ID: mdl-29946353

ABSTRACT

BACKGROUND: Dysfunctional cognitions related to trauma is an important factor in the development and maintenance of post-traumatic stress disorder symptoms in children and adolescents. The Child Post-traumatic Cognitions Inventory (CPTCI) assesses such cognitions about trauma. We investigated the psychometric properties of the Korean version of CPTCI and its short form by surveying child and adolescent survivors of sexual violence. METHODS: Children and adolescents aged 7-16 years (N = 237, Mage = 12.6, SD = 2.3, 222 [93.7%] were female) who were exposed to sexual violence were included in this survey. We assessed the factor structure, internal consistency, and validity of the CPTCI and its short form through data analysis. RESULTS: Confirmatory factor analysis results supported the two-factor model presented in the original study. The total scale, its subscales, and the short form had good internal consistency (Cronbach's α = .96 for total scale and .91-.95 for the other scales). The CPTCI showed high correlations with scales measuring post-traumatic stress symptoms (r = .77-.80), anxiety (r = .69-.71), and depression (r = .74-.77); the correlation with post-traumatic stress symptoms was the highest. The differences in CPTCI scores per post-traumatic stress symptom levels were significant (all p < .001) Sex differences in CPTCI scores were not significant (p > .05 for all comparisons); however, the scores exhibited differences per age group (all p < .001). CONCLUSIONS: The results indicate that the Korean version of the CPTCI is a valid and reliable scale; therefore, it may be a valuable tool for assessing maladaptive cognitions related to trauma in research and clinical settings.

5.
Arch Gerontol Geriatr ; 74: 68-71, 2018 Jan.
Article in English | MEDLINE | ID: mdl-29035740

ABSTRACT

BACKGROUND: There is a growing interest in finding psychosocial predictors related to cognitive function. In our previous research, we conducted a cross-sectional study on memory age identity (MAI) and found that MAI might be associated with objective cognitive performance in non-cognitively impaired elderly. A longitudinal study was conducted to better understand the importance of MAI as a psychosocial predictor related to objective cognitive function. METHODS: Data obtained from 1345 Korean subjects aged 60 years and above were analyzed. During the two-year follow-up, subjective memory age was assessed on three occasions using the following question: How old do you feel based on your memory? Discrepancy between subjective memory age and chronological age was then calculated. We defined this value as 'memory age identity (MAI)'. A generalized estimating equation (GEE) was then obtained to demonstrate the relationship between MAI and Korean version-Mini Mental State Examination (K-MMSE) score over the 2 years of study. RESULTS: MAI was found to significantly (ß=-0.03, p< 0.0001) predict objective cognitive performance in the non-cognitively impaired elderly. CONCLUSION: MAI may be a potential psychosocial predictor related to objective cognitive performance in the non-cognitively impaired elderly.


Subject(s)
Cognition , Memory , Age Factors , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Mental Status and Dementia Tests
6.
J Korean Med Sci ; 32(10): 1680-1686, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28875614

ABSTRACT

More than half of all sexual assault victims report experiencing sexual victimization more than once. The aim of this paper was to determine the role post-traumatic cognition plays in the relationship between a history of sexual abuse and post-traumatic stress symptoms in sexual assault victims. The relationship between a history of sexual assault and the severity of post-traumatic stress symptoms was investigated retrospectively using data from a sexual assault crisis center in Korea. Data on psychological symptoms were collected in person at the initial assessment and by telephone 1 month later using the Post-traumatic Cognitions Inventory and the Post-traumatic Stress Disorder Symptoms Scale: Self-report Version. Of 105 women included in the analysis, 10 (9.5%) reported prior sexual abuse and were classified as sexually revictimized. Revictimized women had more post-traumatic negative cognition at initial assessment (t = -2.98; P = 0.004) and more post-traumatic symptoms at 1 month follow-up (t = -2.39; P = 0.019) than singly victimized women. At 1 month follow-up, the severity of post-traumatic stress symptoms had increased in revictimized women but had decreased slightly in singly victimized women. Negative post-traumatic cognition fully mediated the association between a history of sexual abuse and the severity of post-traumatic stress symptoms. Early detection of sexually revictimized women and tailored service and treatment intervention is needed to better serve this group of victims. Interventions targeted at preventing revictimization or post crime victimization may also help victims recover from the trauma and prevent future abuse.


Subject(s)
Child Abuse, Sexual/psychology , Cognition/physiology , Crime Victims/psychology , Stress Disorders, Post-Traumatic/psychology , Adolescent , Adult , Child , Databases, Factual , Female , Humans , Interviews as Topic , Retrospective Studies , Self Report , Severity of Illness Index , Stress Disorders, Post-Traumatic/pathology , Surveys and Questionnaires , Young Adult
7.
J Affect Disord ; 217: 260-265, 2017 08 01.
Article in English | MEDLINE | ID: mdl-28437763

ABSTRACT

BACKGROUND: Distress in cancer patients leads to poorer quality of life (QOL) and negatively impacts survival. For efficient management of a patient's disease course, the interrelationships among distress, depression, insomnia, and QOL must be understood. This study aimed to investigate whether depression and insomnia mediate the relationship between distress and QOL in cancer patients. METHODS: Cancer patients referred to a specialized psycho-oncology clinic (n=208) participated in this study. Distress, depression, insomnia, and QOL were measured with the following questionnaires: Distress Thermometer, Hospital Anxiety and Depression Scale, Insomnia Severity Index, and Functional Assessment of Cancer Therapy-General. Structural equation modeling and path analysis were performed to analyze the mediating effects of depression and insomnia on the relationship between distress and QOL. RESULTS: Distress exerted nearly equal direct (ß=-0.291, p=0.002) and indirect (mediated by depression and insomnia) (ß=-0.299, p=0.003) negative effects on QOL. Depression exhibited the largest direct negative effect on QOL. The indirect effects of distress on QOL through depression alone, through insomnia alone, and through an insomnia to depression pathway were all significant (ß=-0.122, p=0.011; ß=-0.102, p=0.002; and ß=-0.075, p<0.001, respectively). LIMITATIONS: The cross-sectional analyses limit the measurement of causal relationships between each variable. CONCLUSIONS: Depression and insomnia, both individually and as part of an interrelated pathway, partially mediate the relationship between distress and QOL. Appropriate interventions to alleviate insomnia and depression may mitigate the negative impacts of distress on QOL in cancer patients.


Subject(s)
Depressive Disorder/psychology , Neoplasms/psychology , Quality of Life/psychology , Sleep Initiation and Maintenance Disorders/psychology , Adult , Cross-Sectional Studies , Depressive Disorder/etiology , Female , Humans , Male , Middle Aged , Neoplasms/complications , Surveys and Questionnaires
8.
J Alzheimers Dis ; 56(4): 1341-1348, 2017.
Article in English | MEDLINE | ID: mdl-28157103

ABSTRACT

BACKGROUND/OBJECTIVE: We aimed to compare the risk of mortality in patients with early-onset Alzheimer's disease (EOAD) versus those with late-onset AD (LOAD) using a large number of study subjects. We applied propensity score matching (PSM) to minimize confounding biases in the comparison between EOAD and LOAD. METHODS: We obtained data from elderly Korean subjects with AD (n = 3,611) at baseline from the CREDOS cohort study, which was conducted from November 2005 to July 2013. We conducted PSM to reduce the bias due to confounding variables related to survival in patients with AD. The risks of mortality associated with EOAD and LOAD were evaluated by Cox proportional hazard analyses, controlling for relevant covariates. RESULTS: After propensity score matching, 312 subjects with EOAD and 624 subjects with LOAD were selected for further analysis. The Cox proportional hazard analysis showed that patients with EOAD are at a greater risk for mortality compared to those with LOAD (Hazard Ratio: 2.01, 95% CI: 1.01-4.00, p-value: 0.04) when controlling for the direct effect of aging on mortality. The results did not change after adjusting for age at diagnosis, general cognitive function, nutritional factor related to body mass index, and physical disability using activities of daily living. The results support the assumption that EOAD takes a more malignant course than LOAD. CONCLUSIONS: Our results provide support for the idea that EOAD takes a clinical course that is distinct from that of LOAD, especially as pertains to the risk of mortality.


Subject(s)
Alzheimer Disease/mortality , Age of Onset , Aged , Alzheimer Disease/diagnosis , Female , Follow-Up Studies , Humans , Male , Middle Aged , Propensity Score , Proportional Hazards Models , Republic of Korea , Risk
9.
J Alzheimers Dis ; 53(2): 463-73, 2016 05 03.
Article in English | MEDLINE | ID: mdl-27163831

ABSTRACT

BACKGROUND: In keeping with increasing interest in dementia, few recent studies suggest that clinical course of mild cognitive impairment vary across different studies with hospital-based subjects showing higher rates of conversion than community-based subjects. OBJECTIVE: The main objective of the present study was to assess whether the clinical conversion or reversion rates differ according to recruitment source. METHODS: The baseline study subjects comprised of patients who were diagnosed with mild cognitive impairment in community-based GDEMCIS or hospital-based CREDOS. The two studies had nearly the same protocol and were performed over a similar period. We used propensity score matching for baseline comparability. After that, Cox proportional hazards regression analyses were conducted to estimate the hazard ratios and 95% confidence intervals of clinical conversion or reversion. RESULTS: Based on 89 GDEMCIS subjects, 1 : 4 propensity score matching was conducted and 356 CREDOS subjects were selected. After adjusting for covariates including baseline demographics, comorbidity, depression, disability, and neuropsychological result, Cox proportional hazard regression analysis for time to clinical conversion indicated that recruitment from hospital-based CREDOS exhibited hazard ratio of 2.13 (95% CI, 1.08-4.21), as compared to recruitment from community-based GDEMCIS. Similarly, Cox proportional hazard regression analysis for time to reversion indicated that recruitment from hospital-based CREDOS exhibited hazard ratio of 0.34 (95% CI, 0.20-0.59), as compared to recruitment from community-based GDEMCIS. CONCLUSION: The present study demonstrated that even after the matching process and adjustments for baseline covariates, recruitment source greatly affected the course of mild cognitive impairment.


Subject(s)
Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/epidemiology , Dementia/diagnosis , Dementia/epidemiology , Aged , Aged, 80 and over , Community Health Centers , Disease Progression , Female , Hospitals , Humans , Kaplan-Meier Estimate , Longitudinal Studies , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Proportional Hazards Models , Psychiatric Status Rating Scales , Republic of Korea , Time Factors
10.
Arch Gerontol Geriatr ; 66: 7-12, 2016.
Article in English | MEDLINE | ID: mdl-27174125

ABSTRACT

BACKGROUND: We compared the validity of models of subcortical ischemic depression (SID) and depression-executive dysfunction syndrome (DED) in predicting functional disability in the elderly. METHODS: We obtained data from elderly Korean subjects (n=1356) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A generalized estimating equation (GEE) model was constructed to measure functional disability using instrumental activity of daily living as a primary outcome. A risk factor of interest was SID and DED evaluated by a visual rating scale of deep white matter hyperintensity in MRI, Stroop test and Geriatric Depression Scale (GDS) score. Receiver-operating-characteristic plots and area under the curve (AUC) test were applied to examine the difference of the two definitions of vascular depression with predicted values of functional disability outcome. RESULTS: The mean (SD) follow-up duration of the participants was 1.7 (0.9) years. The GEE model showed that presence of SID at baseline predicted functional disability compared to non-depressed subjects (GDS score: Odds ratio [OR] 1.76; 95% CI 1.23, 2.53; p=0.002). The association was also statistically significant among the DED group (OR 1.48; 95% CI 1.15, 1.92; p=0.003). There were no significant differences in predicting functional disability (95% CI: -0.003 to 0.009, p=0.366) according to AUC differences between SID and DED. CONCLUSIONS: The results will be useful in evaluating the cardinal features of the vascular depression hypothesis in predicting functional disability.


Subject(s)
Cerebrovascular Disorders/diagnosis , Depression/diagnosis , Depressive Disorder/diagnosis , Executive Function , White Matter/diagnostic imaging , Aged , Aged, 80 and over , Area Under Curve , Cerebrovascular Disorders/diagnostic imaging , Cerebrovascular Disorders/psychology , Depression/diagnostic imaging , Depression/psychology , Depressive Disorder/diagnostic imaging , Depressive Disorder/psychology , Female , Humans , Longitudinal Studies , Magnetic Resonance Imaging , Male , Middle Aged , ROC Curve , Republic of Korea , Risk Factors
11.
Medicine (Baltimore) ; 94(45): e1918, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26559259

ABSTRACT

To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD).Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included. A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline.After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory, and attention), the Cox proportional hazard regression analysis revealed that risk of a hip fracture was decreased with a hazard ratio (HR) of 0.98 per one point of increase in the Stroop Test (adjusted HR = 0.98, 95% confidence interval [CI]: 0.97-1.00) and 0.93 per one point increase in COWAT (adjusted HR = 0.93, 95% CI: 0.88-0.99).The risk of hip fracture in AD patients was associated with baseline frontal lobe function. The result of this research presents evidence of association between frontal lobe function and risk of hip fracture in patients with AD.


Subject(s)
Alzheimer Disease/psychology , Frontal Lobe/physiopathology , Hip Fractures/epidemiology , Aged , Aged, 80 and over , Alzheimer Disease/complications , Female , Humans , Male , Neuropsychological Tests , Proportional Hazards Models , Retrospective Studies , Risk Factors
12.
J Affect Disord ; 188: 28-34, 2015 Dec 01.
Article in English | MEDLINE | ID: mdl-26340080

ABSTRACT

BACKGROUND: We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE ε4 status in the elderly. METHODS: We obtained data from elderly Korean subjects (n=707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model stratified according to APOE genotype (APOE ε4 carrier vs. non-carrier) was constructed using GDS score as a primary outcome and degree of overall, deep, periventricular WMH evaluated by a visual rating scale as a risk factor of interest. We also tested interaction between APOE ε4, WMH and time as predictors of clinical progression on GDS scores to examine the moderating effect of APOE ε4 allele on the relationship between degree of WMH and progression of geriatric depressive symptoms. RESULTS: The mean (SD) follow-up duration of the participants was 2.0 (0.8) years. Among APOE ε4 carriers, a severe degree of overall and deep WMH, but not periventricular WMH, predicted progression of geriatric depressive symptoms (overall WMH: coefficient=0.96, p=0.010; deep WMH: 0.87, p=0.016). There were significant interaction between APOE ε4, degree of WMH and time in predicting GDS increase (5df, F=2.28, p=0.046). LIMITATIONS: Only subjects seeking medical attention and with follow-up measurements were enrolled in this study. Specific location of WMH and use of antidepressant were uncontrolled. CONCLUSIONS: Considering biological markers such as degree of WMH and APOE ε4 status may be clinically relevant to predicting progression of geriatric depressive symptoms.


Subject(s)
Apolipoprotein E4/genetics , Depression/genetics , Depression/pathology , White Matter/pathology , Aged , Aged, 80 and over , Disease Progression , Endophenotypes , Female , Genotype , Geriatric Assessment , Humans , Late Onset Disorders/genetics , Late Onset Disorders/pathology , Linear Models , Magnetic Resonance Imaging , Male , Middle Aged , Neuroimaging , Risk Factors
13.
PLoS One ; 10(7): e0132838, 2015.
Article in English | MEDLINE | ID: mdl-26172441

ABSTRACT

BACKGROUND: We examined the longitudinal association between participation in individual or combinations of physical, social, and religious activity and risk of depression in the elderly. METHODS: Elderly subjects aged ≥ 60 years who completed the Living Profiles of Older People Survey in Korea (n = 6,647) were included. The baseline assessment, Wave 1, was conducted in 2008, and a follow-up assessment, Wave 2, was conducted in 2011. We defined participation in frequent physical activity as ≥ 3 times weekly (at least 30 minutes per activity). Frequent participation in social and religious activity was defined as ≥ 1 activity weekly. The primary outcome was depression at 3-year follow up. RESULTS: Multivariable logistic regression analysis showed that subjects who participated in frequent physical, social, and religious activity had an adjusted odds ratio of 0.81 (95% confidence interval [CI], 0.69-0.96), 0.87 (95% CI, 0.75-1.00), and 0.78 (95% CI, 0.67-0.90), respectively, compared with participants who did not participate in each activity. Participants who participated in only one type of activity frequently and participants who participated in two or three types of activities frequently had an adjusted odds ratio of 0.86 (95% CI, 0.75-0.98) and 0.64 (95% CI, 0.52-0.79), respectively, compared with participants who did not participate in any type of physical, social, and religious activity frequently. CONCLUSION: Participation in physical, social, and religious activity was associated with decreased risk of depression in the elderly. In addition, risk of depression was much lower in the elderly people who participated in two or three of the above-mentioned types of activity than that in the elderly who did not.


Subject(s)
Depression/etiology , Depressive Disorder/etiology , Motor Activity/physiology , Aged , Female , Follow-Up Studies , Humans , Longitudinal Studies , Male , Religion , Republic of Korea , Residence Characteristics , Risk , Social Support , Surveys and Questionnaires
14.
J Affect Disord ; 184: 145-8, 2015 Sep 15.
Article in English | MEDLINE | ID: mdl-26093033

ABSTRACT

BACKGROUND: Victimization by sexual violence is strongly associated with the development of posttraumatic stress disorder (PTSD). While several psychological and cognitive factors are known to be associated with PTSD prognosis, multivariable analysis is scarce. This study examined factors affecting the severity of PTSD symptoms in early stage of traumatic experience of sexual violence, including initial post-traumatic symptoms and cognitive characteristics. METHODS: Participants were recruited from the center for women and children victims of violence in a university hospital. Thirty-four sexual assault victims were assessed at the baseline and the second visit one to five months after the baseline. At the baseline, an array of posttraumatic symptoms and cognitive functions were measured: at follow-up, PTSD symptoms were determined by Clinician Administered PTSD Scale. RESULTS: Stepwise multiple regression showed that avoidance symptoms (ß = 0.551, P < 0.01) and delayed verbal memory (ß = -0.331, P < 0.05) at early stage of trauma predicted the severity of PTSD symptoms one to five month later. The regression model, factoring in avoidance and delayed verbal memory, showed a 34.9% explanatory power regarding the PTSD symptom severity. CONCLUSION: This study suggests that avoidance symptoms and verbal memory at the early stage of trauma are associated with later PTSD symptoms. It is also suggested that early intervention targeting avoidance symptoms may be beneficial in decreasing PTSD symptoms.


Subject(s)
Avoidance Learning , Cognition , Crime Victims/psychology , Memory Disorders/psychology , Sex Offenses/psychology , Stress Disorders, Post-Traumatic/psychology , Adolescent , Adult , Female , Humans , Memory Disorders/complications , Middle Aged , Stress Disorders, Post-Traumatic/complications , Stress Disorders, Post-Traumatic/diagnosis
15.
PLoS One ; 10(3): e0119180, 2015.
Article in English | MEDLINE | ID: mdl-25768018

ABSTRACT

BACKGROUND AND AIMS: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline. METHODS: Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed. RESULTS: After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019; Controlled Oral Word Association Test, -0.176 [-0.328, -0.023], p = 0.024; Stroop Test, -0.304 [-0.458, -0.150], p<0.001). CONCLUSIONS: These findings suggest that the plasma HSP 70 level may be related to cognitive decline in the elderly.


Subject(s)
Cognitive Dysfunction/blood , Cognitive Dysfunction/pathology , HSP70 Heat-Shock Proteins/blood , Aged , Cohort Studies , Dementia/blood , Dementia/pathology , Disease Progression , Female , Follow-Up Studies , HSP27 Heat-Shock Proteins/blood , Humans , Male
16.
Arch Gerontol Geriatr ; 60(1): 183-9, 2015.
Article in English | MEDLINE | ID: mdl-25442783

ABSTRACT

PURPOSE: Our study aimed to assess the longitudinal association of frequency of contact with non-cohabitating adult children and risk of depression in the elderly. METHODS: Elderly aged ≥60 years were included from Living Profiles of Older People Survey (LPOPS) in Korea. The baseline assessment, Wave 1, was conducted in 2008, and follow-up assessment, Wave 2, was conducted in 2011. We included participants who completed both waves and excluded those who met the following criteria: no adult children, living with adult children, cognitive impairment at either waves, and depression at baseline (n=4398). We defined infrequent contact as <1 time per month face-to-face contact or <1 time per week phone contact and classified participants into four groups based on contact method and frequency. Depression was measured using the 15-item geriatric depression scales (SGDS-K). RESULTS: In multivariable logistic regression analysis, infrequent face-to-face and phone contact group had adjusted odds ratio (OR) of 1.86 (95% CI, 1.44-2.42) when compared with frequent face-to-face and phone contact group. Frequent face-to-face contact with infrequent phone contact group and infrequent face-to-face contact with frequent phone contact group had adjusted OR of 1.49 (95% CI, 1.12-1.98) and 1.44 (95% CI, 1.15-1.80), respectively, when compared with frequent face-to-face and phone contact group. CONCLUSION: These results propose that the risk of subsequent depression in elderly is associated with frequency of contact with non-cohabitating adult children. Moreover, the efficacy of face-to-face contact and that of phone contact were similar, while the group lacking both types of contact demonstrated the highest risk of depression.


Subject(s)
Adult Children , Depression/psychology , Intergenerational Relations , Interpersonal Relations , Aged , Aged, 80 and over , Community-Based Participatory Research , Depressive Disorder , Female , Health Surveys , Humans , Longitudinal Studies , Male , Middle Aged , Republic of Korea , Risk
17.
Psychother Psychosom ; 83(5): 270-8, 2014.
Article in English | MEDLINE | ID: mdl-25116574

ABSTRACT

BACKGROUND: A healthy lifestyle may protect against cognitive decline. We examined outcomes in elderly individuals after 18 months of a five-group intervention program consisting of various modalities to prevent cognitive decline. METHODS: We conducted a cluster randomized controlled trial assessing 460 community-dwelling individuals aged 60 years and older in a geriatric community mental health center in Suwon, Republic of Korea, between 2008 and 2010. We developed an intervention program based on the principles of contingency management, which could be delivered by ordinary primary health workers. Group A (n = 81) received standard care services. Group B (n = 80) received bimonthly (once every 2 months) telephonic care management. Group C (n = 111) received monthly telephonic care management and educational materials similar to those in group B. Group D (n = 93) received bimonthly health worker-initiated visits and counseling. Group E (n = 94) received bimonthly health worker-initiated visits, counseling, and rewards for adherence to the program. RESULTS: The primary outcome was the change in Mini-Mental State Examination (MMSE) scores from baseline to the final follow-up visit at 18 months. Group E showed superior cognitive function to group A (adjusted coefficient ß = 0.99, p = 0.044), with participation in cognitive activities being the most important determining factor among several health behaviors (adjusted coefficient ß = 1.04, p < 0.01). CONCLUSIONS: Engaging in cognitive activities, in combination with positive health behaviors, may be most beneficial in preserving cognitive abilities in community-dwelling older adults.


Subject(s)
Cognition Disorders/prevention & control , Risk Reduction Behavior , Aged/psychology , Cognition , Cognition Disorders/epidemiology , Female , Health Behavior , Health Services for the Aged , Humans , Male , Neuropsychological Tests , Republic of Korea , Single-Blind Method
18.
J Korean Med Sci ; 29(6): 831-6, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24932086

ABSTRACT

This study prospectively examined the relationships among cognitive factors and severity of Posttraumatic stress disorder (PTSD) symptoms in female victims of sexual violence. Thirty-eight victims of sexual violence recruited from Center for Women Victims of Sexual and Domestic Violence at Ajou University Hospital. Cognitive factors and PTSD symptom were assessed within 4 months of sexual violence and 25 victims were followed-up 1 month after initial assessment. Repeated-measured ANOVA revealed that PTSD incidence and severity decreased over the month (F [1, 21]=6.61). Particularly, avoidant symptoms might decrease earlier than other PTSD symptoms (F [1, 21]=5.92). This study also showed the significant relationship between early negative trauma-related thoughts and subsequent PTSD severity. Shame and guilt proneness had significant cross-sectional correlations with PTSD severity, but did not show associations when depression severity is controlled. Our results suggest that avoidant symptoms might decrease earlier than other PTSD symptoms during the acute phase and that cognitive appraisals concerning the dangerousness of the world seem to play an important role in the maintenance of PTSD (r=0.499, P<0.05).


Subject(s)
Cognition , Sex Offenses , Stress Disorders, Post-Traumatic/diagnosis , Adolescent , Adult , Cross-Sectional Studies , Depression/diagnosis , Depression/etiology , Female , Follow-Up Studies , Humans , Pilot Projects , Prospective Studies , Psychiatric Status Rating Scales , Severity of Illness Index , Stress Disorders, Post-Traumatic/etiology , Surveys and Questionnaires , Women , Young Adult
19.
Arch Gerontol Geriatr ; 59(2): 468-73, 2014.
Article in English | MEDLINE | ID: mdl-24852666

ABSTRACT

Our study aimed to examine the relationship between perceived sleep quality and depression using Pittsburgh Sleep Quality Index (PSQI) and Cole's model to materialize the concept of perceived sleep quality in the non-cognitively impaired elderly. Older adults aged 60+ were recruited from the baseline study of Suwon Project (SP) between 2009 and 2011 (n=2040). Perceived sleep quality was measured using the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K), and depression was accessed using the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K). We excluded the cognitively impaired elderly using the Korean version-Mini Mental Status Examination (K-MMSE) score less than or equal to 17. In multivariable adjusted logistic regression related to PSQI-K components, poor perceived sleep quality, including poor subjective sleep quality (Odds ratio (OR)=1.27, 95% confidence interval (CI)=1.01-1.61), longer sleep latency (OR=1.32, 95% CI=1.13-1.55) and the frequent use of sleeping medication (OR=1.30, 95% CI=1.10-1.53) were significantly associated with depression after adjusting for age, sex, education, living status, current smoking and current alcohol drinking, the number of comorbidity and Beck Anxiety Inventory (BAI). PSQI-K global score also had greater odds of reporting depression (OR=1.12, 95% CI=1.07-1.16). These results suggested that poor perceived sleep quality was associated with a greater level of depression in the elderly.


Subject(s)
Depression/epidemiology , Sleep Wake Disorders/epidemiology , Age Factors , Aged , Aged, 80 and over , Depression/psychology , Female , Geriatric Assessment , Humans , Male , Middle Aged , Prevalence , Prospective Studies , Psychiatric Status Rating Scales , Republic of Korea/epidemiology , Risk Factors , Sleep Wake Disorders/psychology
20.
Child Psychiatry Hum Dev ; 45(6): 746-52, 2014 Dec.
Article in English | MEDLINE | ID: mdl-24526458

ABSTRACT

This study investigated the socio-demographic characteristics and emotional and behavioral factors associated with the perceived need and actual use of adolescent mental health services according to genders in Korea. We assessed 1,857 middle school students aged 14-16 years. We administered a self-reported questionnaire including questions on their socio-demographic data, Korean Youth Self Report, and self perceived need and actual use of mental health services. Overall, 11.6 % of the adolescents demonstrated a self perceived need for mental health services regarding their emotional or behavioral problems, while 2.1 % had sought mental health services. There were discrepancies between the perceived need and actual use. Most adolescents (81.6 %) used mental health services without self-perceived need, and only 3.3 % of adolescents with self-perceived need utilized mental health services. The perceived need of mental health services is positively influenced by the adolescent's anxious/depressed problems in both genders. The use of them is negatively influenced by the withdrawn problem in adolescent boys, while positively influenced by the aggressive behavior in adolescent girls. To increase the actual use of mental health services more attention needs to be focused on their internalizing problems, such as anxious/depressed and withdrawn problems, in addition to externalizing problems in both genders.


Subject(s)
Adolescent Health Services/statistics & numerical data , Health Services Needs and Demand , Mental Disorders/therapy , Mental Health Services/statistics & numerical data , Sex Characteristics , Adolescent , Adolescent Behavior/psychology , Emotions , Female , Humans , Male , Mental Disorders/psychology , Perception , Republic of Korea , Socioeconomic Factors , Surveys and Questionnaires
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