ABSTRACT
The COVID-19 pandemic is threatening people's health and economic development around the world. Many areas and cities are opting for actions such as lockdown or closed-off management to prevent rapid spread of the virus. Under these actions, it is necessary and important to guarantee the supply of essential goods. In this paper, we develop a multi-objective optimization model to optimize the supply of essential goods under closed-off management. A mixed binary integer programming model is built to help identify the optimal safety stock level as well as the supply network so that the demands for essential goods could be guaranteed. The effectiveness of our method is demonstrated by an example. We also perform sensitivity analysis for key parameters. Our work provides a reasonable solution for the supply of essential goods under closed-off management.
ABSTRACT
OBJECTIVE To investigate the pathogenic change and bacterial antibiotic resistance in lower respiratory tract infection in inpatients of chronic pulmonary heavt disease(CPHD) for recently 3 years and to provide reference for clinical treatment.METHODS Retrospective analysis was conducted on sputum cultivation from CPHD patients who were hospitalized from Jan 2004 to Dec 2006.RESULTS A total of 772 pathogenic strains were isolated,60.1 % of which were Gram-negative bacilli.Pseudomonas aeruginosa,Klebsiella Pneumoniae,Escherichia coli and Acinetobacter baumannii were the main Gram-negative pathogens.Gram-positive bacilli accounted for 13.7%,most of which were Streptococcus pneumoniae,Staphylococcus aureus and so on.Fungi accounted for 26.2%.Imipenem/cilastatin sodium was the most sensitive drug for P.aeruginosa,Acinebacter and Enterobacteriaceae.And vancomycin hydrochloride was the most for S.aureus.Their multiple drug-resistance to anti-microbial agents was serious.CONCLUSIONS Gram-negative bacteria are the majority of the pathogens from CPHD of lower respiratory tract infection in hospital.The pathogens show multiple drug-resistance in drug sensitive test.It is suggested that there be urgent need for surveillance of bacterial resistance and rational use of anti-microbial agents during the clinical therapy.
