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[Investigation of Prophylactic Efficacy of Triazavirin Against Experimental Forest- Spring Encephalitis on Albino Mice].
Loginova, S Ya; Borisevich, S V; Rusinov, V L; Ulomsky, U N; Charushin, V N; Chupakhin, N; Sorokin, P V.
Antibiot Khimioter ; 60(5-6): 8-11, 2015.
Article in Russian | MEDLINE | ID: mdl-26852489

ABSTRACT

Prophylactic efficacy of Triazavirin against experimental Forest-Spring encephalitis was studied on albino mice. vs. the active drug Ribavirin. A significant increase of the animal lifespan in the test groups (from 4 to 5 days) and a statistically (p < or = 0.05) valid decrease of the virus accumulation level in the target organ (the brain) were observed.


Subject(s)
Azoles/pharmacology , Encephalitis, Tick-Borne/prevention & control , Triazines/pharmacology , Animals , Brain/metabolism , Brain/pathology , Brain/virology , Cell Line , Disease Models, Animal , Encephalitis, Tick-Borne/metabolism , Encephalitis, Tick-Borne/pathology , Mice , Swine , Triazoles
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