ABSTRACT
Erythroderma is a skin lesion characterized by redness, swelling, infiltration, and desquamation of greater than 90% of the skin. The etiology of erythroderma is not completely clear and the lesion can be manifestations of various chronic dermatoses, including atopic dermatitis, psoriasis, eczema, and toxicodermia, and be represented by erythrodermic mycosis fungoides. The pathogenesis of erythroderma especially at the genetic level remains little studied. Thus, one disease (erythroderma) can be a manifestation of different dermatoses and have similar clinical and histological signs. This paper gives a review of modern literature on the study of erythroderma in terms of morphology and genetic aspects.
Subject(s)
Connexins/genetics , Dermatitis, Atopic/pathology , Dermatitis, Exfoliative/pathology , Psoriasis/pathology , Dermatitis, Atopic/genetics , Dermatitis, Exfoliative/classification , Dermatitis, Exfoliative/genetics , Eczema/genetics , Eczema/pathology , Humans , Mycosis Fungoides/genetics , Mycosis Fungoides/pathology , Psoriasis/genetics , Skin/metabolism , Skin/pathologyABSTRACT
An immunohistochemical study of p53, Ki-67, bcl-2, CK-8 and collagen IV was conducted in 47 basal-cell carcinomas (BCC) to ascertain their prognostic value. The increasing index of the proliferative markers (Ki-67 up to 55.71 and p53 up to 63.29%, respectively) was characteristic of infiltrative BCC (p = 0.017-0.027). There was a distinct correlation between p53 and Ki-67 levels, on the one hand, and the main clinico-morphological features of BCC (r=0.63-0.78), on the other. Elevated expression of proliferative markers proved to be a factor of unfavorable prognosis. High anti-apoptotic bcl-2 expression in superficial BCC (36.85%) was matched by its decrease in nodular carcinoma and was minimal in high grade infiltrative BCC (13.24%). CK-8 expression did not vary significantly within the 67.21-71.39% of tumor cells as far as different histotopographic patterns are concerned. Most prominent basement membrane ruptures, as evaluated by collagen IV expression, occurred in infiltrative BCC (p=0.008).
Subject(s)
Biomarkers, Tumor/analysis , Carcinoma, Basal Cell/chemistry , Carcinoma, Basal Cell/pathology , Skin Neoplasms/chemistry , Skin Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Basement Membrane/chemistry , Basement Membrane/pathology , Biomarkers, Tumor/immunology , Collagen Type IV/analysis , Female , Humans , Immunohistochemistry , Keratin-8/analysis , Ki-67 Antigen/analysis , Male , Middle Aged , Neoplasm Invasiveness , Proto-Oncogene Proteins c-bcl-2/analysis , Tumor Suppressor Protein p53/analysisABSTRACT
The paper represents an overview of updated literature concerning common skin neoplasms. The clinical manifestation of the basal cell carcinoma varies significantly according to the patients age, tumor size, localization and duration of the neoplastic process, histological type of the tumor, including proliferative activity and stromal reactions.
Subject(s)
Carcinoma, Basal Cell , Skin Neoplasms , Biomarkers, Tumor/metabolism , Carcinoma, Basal Cell/metabolism , Carcinoma, Basal Cell/pathology , Humans , Skin Neoplasms/metabolism , Skin Neoplasms/pathologyABSTRACT
Gastric tumor in a male of 67 is reported. Immunohistochemically and morphologically the tumor is classified as a stromal stomach neoplasm. Size, mitotic activity, necroses, destruction of the mucous membrane suggest malignancy.
