Short- and Long-Term Outcomes of Suboptimal Medication Adherence in Adolescents with Attention-Deficit/Hyperactivity Disorder: A Systematic Literature Review.

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition with severe and life-long consequences. Adolescents and young adults represent a particularly vulnerable subgroup because of the unique demands of their developmental stage. Despite the well-known efficacy of medication treatment for ADHD, there remains a notable concern regarding poor medication adherence in this population. Objectives: This systematic literature review aimed to synthesize the existing empirical evidence on the outcomes and consequences of medication nonadherence among adolescents and young adults with ADHD. Methods: An extensive database search was conducted on September 26, 2022, with no time limits applied. The databases included Scopus, PubMed, CINAHL, Cochrane, and PsycINFO. Results: Six studies met the inclusion criteria. Each study revealed that medication nonadherence was associated with a range of adverse outcomes, including decreased academic performance, heightened familial, and psychological stress, and an increased likelihood of substance use, pregnancy, obesity, and injury. Conversely, adherence led to improvements in at least one ADHD-related outcome. Conclusions: Research exploring the consequences of suboptimal medication adherence in adolescents and young adults with ADHD is currently limited, and effective strategies to address this issue remain scarce. A thorough understanding of such consequences is critical for developing interventions aimed at improving medication adherence and mitigating the risk of adverse outcomes, especially considering the susceptibility of this population.

Broadening our understanding of what drives stewardship engagement: Relationships between social capital and willingness to engage in nature stewardship.

Diverse solutions are needed to reduce human impacts on nature. Fostering individual stewardship behaviours that protect, restore, and encourage sustainable use of nature will need to be part of this mix of solutions. A key challenge then is how to increase the uptake of such behaviours. Social capital provides a framework to explore the diverse types of social influences on nature stewardship. We surveyed a representative sample of residents of New South Wales, Australia (n = 3220) to explore how facets of social capital influenced individual willingness to adopt diverse types of stewardship behaviours. Analysis confirmed that parts of social capital differentially influence distinct types of stewardship behaviours including lifestyle, social, on-ground, and citizenship behaviours. All behaviours were positively influenced by perceptions of shared values within social network, and past participation in environmental groups. Yet some components of social capital exhibited mixed associations with each type of stewardship behaviour. For example, collective agency was associated with greater willingness to engage in social, on-ground, and citizenship behaviours, whereas institutional trust was negatively associated with willingness to engage in lifestyle, on-ground and citizenship behaviours. These findings show that social context provides an important foundation for building stewardship engagement.

Relationship between estimated glomerular filtration rate and incident cardiovascular disease in an ethnically diverse primary care cohort.

AIM: To investigate eGFR as an independent risk factor for CVD in a New Zealand primary care cohort, stratified by disease status (prior CVD, diabetes or no CVD or diabetes). METHOD: The PREDICT-CVD open cohort study is a large, ethnically diverse, New Zealand primary care cohort, generated by using a web-based CVD risk assessment tool. Using encrypted identifiers, participant profiles were linked anonymously to a regional laboratory database (to determine renal function) and to national hospitalisation and mortality datasets. Analyses using a single baseline eGFR measurement were undertaken in three clinical sub-cohorts of participants: those with prior CVD (n=29,742), with diabetes (n=44,416) and with neither CVD nor diabetes (n=192,696). The association between baseline eGFR (by category ≥90, 60-89.9, 30-59.9, and <30ml/min/1.73m2) and incident CVD was analysed with Kaplan Meier plots and Cox regression models. RESULTS: After adjustment for traditional CVD risk factors, there was an inverse relationship between CVD risk and eGFR, up to an eGFR of 60ml/min/1.73m2 in all three clinical sub-cohorts, and up to an eGFR of 90ml/min/1.73m2 in the sub-cohort with CVD or diabetes. Compared to eGFR ≥90ml/min/1.73m2, the adjusted hazard ratios of a new CVD event for eGFR <30ml/min/1.73m2 in the CVD, diabetes and no CVD/no diabetes sub-cohorts were 2.29 (95% CI 2.00-2.61), 4.71 (3.92-5.67) and 2.78 (2.05-3.77), respectively. Compared to European/Other ethnic groups, Maori participants remained at greater adjusted risk of a new CVD event in all clinical sub-cohorts and Pacific people only in the no CVD/no diabetes sub-cohort, whereas Indian participants had a similar adjusted risk to European/Other, and Other Asian patients were consistently at lower adjusted risk. Sensitivity analyses for individuals with consecutive eGFR results (>90 days apart) yielded similar results. CONCLUSION: This study has confirmed that, in a large ethnically diverse primary care cohort, eGFR is a significant independent predictor of CVD risk, and the risk varies by ethnic group.

How do marine and coastal citizen science experiences foster environmental engagement?

Citizen science programs enable community involvement in scientific research. In addition to fostering greater science literacy, some citizen science programs aim to foster engagement in environmental issues. However, few data are available to indicate whether and how citizen science programs can achieve greater environmental engagement. We survey individuals choosing to attend one of seventeen reef citizen science events and examine the extent to which attendees reported three indicators of greater environmental engagement: (i) willingness to share information, (ii) increased support for marine conservation and citizen science, and (iii) intentions to adopt a new behavior. Most participants reported being willing to share information about reef conservation (91%) and described increased support for marine science and conservation (87%). Half of participants (51%) reported intentions to adopt a new conservation behavior. We found that key elements of the citizen science experience associated with these outcomes were learning about actions to protect reefs and coasts (procedural learning), experiencing surprise, and experiencing negative emotions about environmental problems. Excitement was also associated with positive outcomes, but only in participants who were less likely to see themselves as environmental, or were less frequent visitors to reefs and coasts. Importantly, the association between factual learning and environmental engagement outcomes was limited or negative. These findings suggest that the way citizen science experiences make people feel, may be more important for fostering future environmental engagement than factual-based learning. When designing citizen science programs for community members, these findings provide a reminder to not focus on provision of factual information alone, but to highlight environmental impacts while providing meaningful experiences and building environmental skills.