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2.
Khirurgiia (Mosk) ; (6. Vyp. 2): 84-88, 2021.
Article in Russian | MEDLINE | ID: mdl-34032793

ABSTRACT

The problem of chronic postoperative pain has been actualized for the last 20 years all over the world. At least 10-40% of patients suffer from chronic pain after surgery. This review is devoted to the current state of the problem of chronic postoperative pain, risk factors and prediction of chronic pain. The authors emphasize the need for interdisciplinary approach to prevention and treatment of this adverse event.


Subject(s)
Pain, Postoperative , Humans , Pain, Postoperative/diagnosis , Pain, Postoperative/etiology , Pain, Postoperative/prevention & control
3.
Zh Nevrol Psikhiatr Im S S Korsakova ; 118(12): 100-113, 2018.
Article in Russian | MEDLINE | ID: mdl-30698569

ABSTRACT

A systematic review summarizes the results of studies on the efficacy of myorelaxants (tolperisone, tizanidine, thiocolchicoside or baclofen) in the treatment of acute nonspecific low back pain published up to Dec. 2017. The authors conclude that there are enough data to confirm the efficacy of myorelaxants in treatment of nonspecific low back pain, myorelaxants are recommended as monotherapy or in combination with analgesics or NSAID, the nonsedative drugs tolperisone or thiocolchicoside should be preferred.


Subject(s)
Low Back Pain , Analgesics , Anti-Inflammatory Agents, Non-Steroidal , Humans , Tolperisone , Treatment Outcome
4.
Article in Russian | MEDLINE | ID: mdl-28635877

ABSTRACT

Low back pain (LBP) is accompanied by the development of pain syndrome that spreads into the leg in 25-57% of patients. This is an important factor predicting the risk of transition of pain from acute to chronic and is an indirect indicator of disease severity. It is often impossible to specify the primary mechanism facilitated pain irradiation in lumboischialgia because many structures can cause analogous symptoms. Mechanisms of development of LBP are represented by nociceptive, neuropathic and psychogenic components. Currently, the term 'neuropathic back pain' remains rather ambiguous. Existing data suggest that the term 'neuropathic LBP is not confined to classic radiculopathy and is realized through several pathophysiological mechanisms. Lumboischialgia is a clinical appearance of these mechanisms. The authors present main mechanisms of the development of lumboischialgia, discuss clinical markers of neuropathic component of LBP, approaches to its diagnosis and treatment.


Subject(s)
Low Back Pain/etiology , Radiculopathy/complications , Humans , Neuralgia , Pain Measurement
5.
Bull Exp Biol Med ; 142(1): 39-42, 2006 Jul.
Article in English, Russian | MEDLINE | ID: mdl-17369898

ABSTRACT

We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 microg in 10 microl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.


Subject(s)
Arachidonic Acids/metabolism , Cannabinoid Receptor Agonists , Morpholines/metabolism , Naphthalenes/metabolism , Pain/drug therapy , Pain/metabolism , Polyunsaturated Alkamides/metabolism , Analysis of Variance , Animals , Arachidonic Acids/therapeutic use , Benzoxazines , Dose-Response Relationship, Drug , Endocannabinoids , Injections, Spinal , Male , Morpholines/therapeutic use , Naphthalenes/therapeutic use , Pain/chemically induced , Pain Measurement , Penicillin V/administration & dosage , Penicillin V/toxicity , Polyunsaturated Alkamides/therapeutic use , Rats , Rats, Wistar
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