ABSTRACT
The paper compares the levels of TIMP-1 and TIMP-2 in blood serum from patients with head and neck squamous cell carcinoma (HNSCC) to establish correlations with clinico-morphological parameters of the disease and prognosis. Our study involved 140 patients with HNSCC (T1-3N0-3M0) and 38 healthy donors. The level of serum TIMP-1 in patients was significantly higher (p < or = 0.02) while that of TIMP-2 was in inverse correlation with histological grade of tumor (p < or = 0.04) and age (p < or = 0.05). High level of TIMP-1 appeared an unfavorable prognosticator for 2-year relapse-free survival in HNSCC patients (p < or = 0.05). Those of both TIMP-1 and TIMP-2 identified in blood serum prior to therapy involved high risk of metastasis development (p < or = 0.05) and (p < or = 0.05), respectively.
Subject(s)
Biomarkers, Tumor/blood , Carcinoma, Squamous Cell/blood , Carcinoma, Squamous Cell/pathology , Head and Neck Neoplasms/blood , Head and Neck Neoplasms/pathology , Tissue Inhibitor of Metalloproteinase-1/blood , Tissue Inhibitor of Metalloproteinase-2/blood , Adult , Aged , Disease-Free Survival , Female , Humans , Male , Middle Aged , Neoplasm Staging , Predictive Value of Tests , Prognosis , Tissue DonorsABSTRACT
The study included patients with laryngeal cancer (stage III-IV) after laryngectomy. They underwent vocal rehabilitation assisted by biological monitoring using mathematical modeling and computer technology. EORTS QLQ-C30 questionnaires 30 (version 3.0) were used to assess quality of life as a tool of rehabilitative effect evaluation (special QLQ-N&N35 for head and neck tumor patients). Physical, psychological, social and symptomatic parameters were followed through the stages of vocal rehabilitation. On completion of therapy, patients spoke freely; 68% of them recovered their social and professional status.
