ABSTRACT
Outbreaks of skin infections due to Staphylococcus aureus continue to be a major problem in newborn nurseries. In this report, we described how the staphylococcal skin infections were controlled in the nursery during the last 5 1/2 years. An outbreak of staphylococcal skin infection (totally 29 cases) developed in January 1985, and declined dramatically to 3 cases in March of the same year when 3% hexachlorophene (HCP) bathing was used (period 1-January 1985 to March 1985). The infections increased to 30 cases in May when HCP bathing was discontinued and was replaced by baby soap baths (period 2-April 1985 to May 1985). Once again, HCP bathing (period 3-June 1985 to January 1987) was reinstituted and infection rate was reduced. After discontinuation of HCP (period 4-February 1987 to March 1987), another outbreak of staphylococcal skin infection reappeared. It was controlled again with HCP bathing (period 5-April 1987 to April 1988). Daily baby soap baths were continued during period 6 (May 1988 to October 1988), and skin infections increased again. Finally in period 7 (November 1988 to June 1990), daily baby soaps were reinstituted and a triple dye was applied daily to the cord and to the surrounding skin (1 inch diameter) until discharge. During this period, staphylococcal skin infections was reduced to 1-4 cases and no more outbreaks occurred. Our data confirmed that 3% HCP bathing of newborns reduced the infection rate of Staphylococcus aureus during an endemic period, and supported that triple dye may be an alternative to HCP for preventing staphylococcal skin infection in a newborn nursery.
Subject(s)
Cross Infection/prevention & control , Skin Diseases, Infectious/prevention & control , Staphylococcal Infections/prevention & control , Anti-Infective Agents/therapeutic use , Baths , Cross Infection/epidemiology , Disease Outbreaks , Drug Combinations , Gentian Violet/therapeutic use , Hexachlorophene/therapeutic use , Humans , Infant, Newborn , Nurseries, Hospital , Proflavine/therapeutic use , Quaternary Ammonium Compounds/therapeutic use , Skin Diseases, Infectious/epidemiology , Staphylococcal Infections/epidemiologySubject(s)
Myositis/diagnosis , Child , Child, Preschool , Diagnostic Errors , Female , Hepatomegaly/diagnosis , Humans , Male , Myositis/etiology , UltrasonographySubject(s)
Peritonitis, Tuberculous/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Peritonitis, Tuberculous/mortality , PrognosisSubject(s)
Lung/abnormalities , Bronchogenic Cyst/congenital , Bronchogenic Cyst/surgery , Bronchopulmonary Sequestration/surgery , Child , Child, Preschool , Cystic Adenomatoid Malformation of Lung, Congenital/surgery , Female , Humans , Infant , Infant, Newborn , Lung/embryology , Male , PneumonectomySubject(s)
Asphyxia Neonatorum/complications , Cysts/diagnosis , Encephalomalacia/diagnosis , Ultrasonography , Female , Humans , Infant, NewbornSubject(s)
Bottle Feeding/adverse effects , Water Intoxication/etiology , Female , Humans , Hyponatremia/etiology , Infant, Newborn , Male , Seizures/etiologyABSTRACT
Six of 83 asphyxiated neonates showed a diffuse increase of echodensity in bilateral thalami with or without other lesions in the basal ganglia on sonographic examination. The thalamic image still had a fairly high echogenecity compared with the surrounding brain parenchyma on follow up examination and was hence termed the bright thalamus. These six patients had a poor neurological outcome, including psychomotor retardation, spastic diplegia or quadriplegia, microcephaly, failure to thrive, seizures, and one death. The bright thalamus is not an occasional or an isolated sonographic finding of hypoxic-ischaemic encephalopathy, but it may serve as a landmark of severe hypoxic brain damage with adverse outcome.
Subject(s)
Asphyxia Neonatorum/diagnosis , Brain Diseases/diagnosis , Thalamus/pathology , Ultrasonography , Asphyxia Neonatorum/complications , Brain Diseases/etiology , Humans , Infant, Newborn , PrognosisABSTRACT
To differentiate neonatal transient leukemoid proliferation from congenital leukemia at an early stage is often difficult. Bone marrow culture is found to be helpful in this aspect. A normal in vitro growth pattern suggests transient leukemoid proliferation, while an abnormal growth pattern indicates congenital leukemia. A neonate who manifested with pictures mimicking acute myeloblastic leukemia (M1), had a karyotype of 46, XY/46, XY, i(21 q). However, the in vitro growth pattern was normal and so only supportive treatment was given. All the leukemoid manifestations disappeared several months later and he is now a healthy 2 year old boy remaining in complete remission. A second neonate who also displayed features of acute myeloblastic leukemia (M2), had a karyotype of 46, XY/47, XY, + 21 and abnormal in vitro growth pattern. This neonate died at 18 days of age.
