Typology of flexor carpi radialis muscle in human fetuses.

INTRODUCTION: The musculus flexor carpi radialis (FCR) is a muscle with an important function for the mechanics and physiology of the hand. Its isolation during intrauterine development occurs relatively late, which may result in the presence of high variability during the fetal period. The aim of this study is to determine the detailed typology of FCR in the fetal period based on the available material. MATERIAL AND METHODS: A total of 114 human fetuses (53 female, 61 male) aged between 117.0 and 197.0 days of fetal life were included in the study. The research material was derived from the collections of the Department of Anatomy, Medical University of Wroclaw. Fetuses were stored in typical conservation solvents. The study incorporated the following methods: anthropological, preparational, and image acquisition, which was obtained using an innovative digital microscope. Statistical analysis was performed using R software. RESULTS: The typology of FCR was determined based on the characteristics of the distal attachment of the investigated muscle. The statistical analysis revealed a predominance of type I in the examined fetal material - the attachment located on metacarpal bone II (about 82% of cases). Type IV (attachment to the 4th metacarpal bone) occurs with a frequency of less than 10% and the remaining types II and III occur with a frequency of 4-6%. The statistical analysis did not reveal bilateral or dimorphic differences in the prevalence of each FCR type. In respect of the collected anthropometric parameters, no statistically significant dimorphic differences were revealed. For a more complete description, the FCR proportionality index was introduced. The mean value of this index was 0.6 and was independent of the side or sex of the analyzed fetus. CONCLUSIONS: FCR in the fetal period is characterized by a stable course in both the proximal and distal attachments.

Drugs Dosing in Geriatric Patients Depending on Kidney Function Estimated by MDRD and Cockroft-Gault Formulas.

INTRODUCTION: According to the current data, regardless of the method used to estimate GFR, the differences between the obtained results should be insignificant and do not imply therapeutic decisions. The aim of this study was to analyze and compare the eGFR results with the estimated creatinine clearance score calculated according to the Cockroft-Gault equation, and to assess the significance of the difference between these two results. SAMPLE AND METHODS: A study group was constituted of 115 patients, of whom 76 were women and 39 men at the age range of 55-93 years, with a median of 79 years. The study analyzed differences in the assessment of kidney function by comparing the results of eGFR assessed by MDRD method obtained from the laboratory with the calculated values of creatinine clearance using the Cockroft-Gault formula, and examining the correlation between the difference D = eGFR -eClCr and BMI and body surface. RESULTS: In the entire group of patients (N = 115), the significant statistical difference was found between eGFR and eClCr. In the subgroup of patients (N = 45) with the lower baseline eGFR <60, there was no significant difference between eGFR and eClCr, while in the subgroup of patients with baseline eGFR ≥60 (N = 75), there was a significant difference between eGFR and eClCr. The study showed that based on the estimated GFR using both methods (C-G and MDRD), 29.2% and 32.4% of patients, respectively, were incorrectly assigned to given stage of chronic kidney disease. CONCLUSION: Proper assessment of kidney function is very important in order to properly drugs dosing, especially to adjust the doses of drugs metabolized by the kidneys in order to avoid or minimize their nephrotoxic effects.