Subject(s)
Alcoholism/pathology , Liver/pathology , Adult , Alcoholism/physiopathology , Fatty Liver/pathology , Hepatitis/pathology , Humans , Liver/physiopathology , Male , Middle AgedABSTRACT
Serum immunoglobulin levels and alpha1-fetoprotein were measured in 49 male alcoholics entering an abstinence program. These parameters were evaluated in relation to liver histology. Of 49 studied alcoholics, 32 had elevated serum immunoglobulin levels, chiefly IgA, which occurred in 29 patients. IgA elevation was also observed in patients with normal histological picture of the liver. Of 17 alcoholics with normal immunoglobulin levels, in 9, i.e. 53%, liver histology was normal. In the group of 32 alcoholics with elevated immunoglobulin levles, normal liver histology was encountered only in 8 patients, i.e. 25%. Two-month abstinence in 18 alcoholics with previously elevated IgA levels caused their decrease in 12 patients, i.e. 66%. A decrease in IgA was noted even in patients with symptoms of histological worsening. Of 49 alcoholics, only 1 showed significantly elevated alpha1-fetoprotein.
Subject(s)
Alcoholism/immunology , Immunoglobulins/analysis , Liver Diseases/immunology , Liver/cytology , Substance Withdrawal Syndrome/immunology , Adult , Alcoholism/complications , Chemical and Drug Induced Liver Injury/immunology , Fatty Liver/immunology , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Liver/pathology , Liver Cirrhosis/immunology , Liver Diseases/etiology , Liver Diseases/pathology , Male , Middle Aged , Substance Withdrawal Syndrome/pathology , alpha-Fetoproteins/analysisSubject(s)
Liver Diseases/immunology , Antibodies/analysis , Antibodies, Antinuclear/analysis , Antistreptolysin/analysis , Diagnosis, Differential , Erythrocytes/immunology , Hepatitis B Antigens/immunology , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Liver Diseases/diagnosis , Rheumatoid Factor/analysisSubject(s)
Cholecystokinin , Liver Cirrhosis/physiopathology , Pancreas/physiopathology , Secretin , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Pancreas/metabolismABSTRACT
In rabbits given cholecystokinin-pancreozymin intravenously a statistically significant increase in bile volume and alkaline phosphatase (AP) activity was observed. There was also an increase in the total amount of protein, cholesterol, bicarbonates Na, K, Ca, Mg, and the total activity of alkaline phosphatase and leucineaminopeptidase (LAP) secreted in bile within 90 minutes after pancreozymin injection. Pancreozymin had no effect on the concentration and output of taurocholates and the activity of gammaglutamyltranspeptidase (GGTP) and alanineaminotransferase (ALAT) in bile. Secretin neither changes the volume nor the concentration of any of the investigated components in rabbit bile.
