Comparison of three methods of EPR retrospective dosimetry in watch glass.

In this article we present results of our follow-up studies of samples of watch glass obtained and examined within a framework of international intercomparison dosimetry project RENEB ILC 2021. We present three methods of dose reconstruction based on EPR measurements of these samples: calibration method (CM), added dose method (ADM) and added dose&heating method (ADHM). The study showed that the three methods of dose reconstruction gave reliable and similar results in 0.5-6.0 Gy dose range, with accuracy better than 10%. The ADHM is the only one applicable in a real scenario, when sample-specific background spectrum is not available; therefore, a positive verification of this method is important for future use of EPR dosimetry in glass in potential radiation accidents.

EPR dosimetry in glass: a review.

Electron Paramagnetic Resonance (EPR) spectroscopy enables detection of paramagnetic centers generated in solids by ionising radiation. In the last years, the ubiquity of glass in personal utility items increased significance of fortuities retrospective dosimetry based on EPR in glass parts of mobile phones and watches. Despite of fading of the signals and their susceptibility to light, it enables dosimetry at medical triage level of 1-2 Gy. In this article information relevant for assessment of applicability and planning of the EPR dosimetry is presented-particularly at dose levels typical for radiation accidents. Reported data on fading of the radiation-induced spectral components are presented and compared. Effects of light on background spectra and on the dosimetric signals are also presented. It is concluded that when properly accounting for the fading and for the obscuring effects of light, the EPR dosimetry in glasses from mobile phones and watches can be used in dose assessment after radiation accidents.

The effect of sunlight and UV lamp exposure on EPR signals in X-ray irradiated touch screens of mobile phones.

Electron paramagnetic resonance (EPR) signals generated by ionizing radiation in touch-screen glasses have been reported as useful for personal dosimetry in people accidently exposed to ionizing radiation. This article describes the effect of light exposure on EPR spectra of various glasses obtained from mobile phones. This effect can lead to significant inaccuracy of the radiation doses reconstructed by EPR. The EPR signals from samples unexposed and exposed to X-rays and/or to natural and artificial light were numerically separated into three model spectra: those due to background (BG), radiation-induced signal (RIS), and light-induced signal (LIS). Although prolonged exposures of mobile phones to UV light are rather implausible, the article indicates errors underestimating the actual radiation doses in dose reconstruction in glasses exposed to UV light even for low fluences equivalent to several minutes of sunshine, if one neglects the effects of light in applied dosimetric procedures. About 5 min of exposure to sunlight or to light from common UV lamps reduced the intensity of the dosimetric spectral components by 20-60% as compared to non-illuminated samples. This effect strongly limits the achievable accuracy of retrospective dosimetry using EPR in glasses from mobile phones, unless their exposure to light containing a UV component can be excluded or the light-induced reduction in intensity of the RIS can be quantitatively estimated. A method for determination of a correction factor accounting for the perturbing light effects is proposed on basis of the determined relation between the dosimetric signal and intensity of the light-induced signal.

Time evolution of radiation-induced EPR signals in different types of mobile phone screen glasses.

In this study, samples of smart phone touch screen glass sheets and tempered glass screen protectors were examined with respect to their potential application in the dosimetry of ionizing radiation. The glass samples were obtained from various phones with different types of glass. Electron paramagnetic resonance (EPR) spectra of the radiation-induced signals (RIS) are presented and their dose dependence within a dose range of 0-20 Gy. Despite the observed fading with time of the dosimetric components of the signal, the remaining RIS turned out to be strong enough for a reliable dosimetry even 18 month after irradiation. The study also shows that crushing of the glass sheets and water treatment of the samples have no effect on the background and dosimetric EPR signals.

The effect of sunlight and UV lamps on EPR signal in nails.

The effects of illumination of nail clippings by direct sunlight, UV lamps and fluorescent bulbs on native and radiation-induced electron paramagnetic resonance (EPR) signals in nails are presented. It is shown that a few minutes of exposure of the nail clippings to light including a UV component (sunlight and UV lamps) generates a strong EPR signal similar to the other EPR signals observable in nails: native background (BKG), mechanically induced (MIS) or radiation-induced (RIS). This effect was observed in clippings exposed and unexposed to ionizing radiation prior to the light illuminations. An exposure of the clippings to fluorescent light without a UV component generated, within the examined range of the light fluences (up to 240 kJ/m2), an EPR signal with considerably lower yield than UV light. The light-induced signal (LIS) decayed after 10 min of water treatment of the samples. In contrast, it was still observable 3 months after illumination in samples stored in air at room temperature, and 3 weeks in frozen samples, respectively. It is concluded that the LIS can considerably affect assessment of the dosimetric RIS components in irradiated nails, and of the background signals in unirradiated nails, thus contributing to errors in EPR dosimetry in nails.

THE EFFECT OF BACKGROUND SIGNAL AND ITS REPRESENTATION IN DECONVOLUTION OF EPR SPECTRA ON ACCURACY OF EPR DOSIMETRY IN BONE.

This study is about the accuracy of EPR dosimetry in bones based on deconvolution of the experimental spectra into the background (BG) and the radiation-induced signal (RIS) components. The model RIS's were represented by EPR spectra from irradiated enamel or bone powder; the model BG signals by EPR spectra of unirradiated bone samples or by simulated spectra. Samples of compact and trabecular bones were irradiated in the 30-270 Gy range and the intensities of their RIS's were calculated using various combinations of those benchmark spectra. The relationships between the dose and the RIS were linear (R2 > 0.995), with practically no difference between results obtained when using signals from irradiated enamel or bone as the model RIS. Use of different experimental spectra for the model BG resulted in variations in intercepts of the dose-RIS calibration lines, leading to systematic errors in reconstructed doses, in particular for high- BG samples of trabecular bone. These errors were reduced when simulated spectra instead of the experimental ones were used as the benchmark BG signal in the applied deconvolution procedures.

Effects of water treatment and sample granularity on radiation sensitivity and stability of EPR signals in X-ray irradiated bone samples.

The article describes effects of sample conditions during its irradiation and electron paramagnetic resonance (EPR) measurements on the background (BG) and dosimetric EPR signals in bone. Intensity of the BG signal increased up to two to three times after crushing of bone to sub-millimetre grains. Immersion of samples in water caused about 50 % drop in intensity of the BG component followed by its regrowth in 1-2 months. Irradiation of bone samples produced an axial dosimetric EPR signal (radiation-induced signal) attributed to hydroxyapatite component of bone. This signal was stable and was not affected by water. In samples irradiated in dry conditions, EPR signal similar to the native BG was also generated by radiation. In samples irradiated in wet conditions, this BG-like component was initially much smaller than in bone irradiated as dry, but increased in time, reaching similar levels as in dry-irradiated samples. It is concluded that accuracy of EPR dosimetry in bones can be improved, if calibration of the samples is done by their irradiations in wet conditions.

EPR/alanine dosimetry in LDR brachytherapy--a feasibility study.

In this study, we present the results of in vivo dosimetry, using electron paramagnetic resonance in l-alanine, performed on 13 patients treated for gynaecological cancers. The doses from (137)Cs (12 samples) and (192)Ir (one sample) brachytherapy sources were determined inside vagina. The detectors had a form of small cellulose capsules tightly filled with crystalline alanine. The positions of the detectors were reconstructed from two orthogonal radiographs. The planned doses were calculated with a computer planning system (PLATO, Nucletron). The relative deviations between planned and measured doses ranged from -23 to +14%. The mean deviation from the prescribed dose was relatively low (-5%) with SD of 10%. The main sources of differences between the measured and calculated doses were attributed to uncertainty in the determination of the detector position inside the patient's body and to uncontrolled changes in the detector position during the treatment.

Combined effects of high doses and temperature on radiation-induced radicals and their relative contributions to EPR signal in gamma-irradiated alanine.

Electron Paramagnetic Resonance (EPR) study of irradiated l-alanine showed differences in dose-response curves obtained at low and high microwave power for a broad range of doses, up to 3000 kGy. A mathematical model was fitted to experimental data and calculated yields of generation and of destruction of radicals showed variations with microwave power. The calculations were applied to both double integrals of the total EPR signal and to its components reflecting contributions of radicals R1, R2 and R3 in the alanine EPR signal. The relative contributions of radicals R1, R2 and R3 varied with dose >100 kGy; an increase in relative contribution of R3 was accompanied by a decrease in contribution of R1 radicals. The observed fading of EPR signal intensity in samples annealed to 175-208 degrees C was a strong function of dose, and varied by 2-3 orders of magnitude in the dose range examined.

The effect of heating on background and radiation-induced EPR signals in tooth enamel.

The presented study is a continuation of our work performed during participation in the Third International Intercomparison on EPR Tooth Dosimetry. During the process of samples preparation, all 22 enamel samples were accidentally exposed for about 30 min to 150 degrees C temperature. This considerably affected shape of their EPR spectra mainly due to substantial increase in the background signal, which approximately doubled its contribution to the spectra. These effects were studied closer under controlled conditions of the delivered dose and heating temperature using another enamel samples. The observed changes in the spectra shape partially faded within a few days after heating. The heating resulted also in a noticeable generation of a spectral component similar to the dosimetric signal induced in enamel by radiation. The temperature-induced dosimetric component in EPR spectra of the heated samples remained constant for 32 days. Deviations in calculated contributions of the dosimetric signal into total EPR spectra of irradiated sample varied from -12 to +15% of its initial contribution in the non-heated enamel, depending on type of the background spectrum applied in numerical processing of the spectra.

In vivo alanine/EPR dosimetry in daily clinical practice: a feasibility study.

PURPOSE: The objective of this study was evaluation of accuracy of in vivo dosimetry using electron paramagnetic resonance (EPR) in alanine. Additionally, we aimed to identify sources of uncertainty in dose determination and quantitative assessment of physical factors that may result in discrepancies between the measured and planned single-fraction doses. METHODS AND MATERIALS: The measurements were performed using detectors in a form of 1.6 cm x 1.6 cm polyethylene sachets filled with powdered L-alanine. The detectors were taped to the patient's skin and measured the entrance doses for (60)Co and electron beams. Some detectors were covered with buildup material, and some measured the "skin dose." The EPR measurements were performed with a Varian E-4 spectrometer. RESULTS: The calculated uncertainty of EPR measured doses was dependent on measured doses and varied from 6.6% for 0.5 Gy to 3.2% for 2 Gy. The calculated uncertainty was in concordance with experimentally determined reproducibility of EPR signals. However, the deviations between measured and planned doses exceeded the uncertainty range of EPR measurements, which can be attributed to uncertainty in determination of actually delivered doses to the detectors, on the basis of treatment planning data. CONCLUSION: The accuracy of dose determination by EPR measurements was shown to be achievable within the 5% limit recommended by the ICRU for doses above 0.7 Gy. The accuracy of in vivo verification of radiotherapy doses by in vivo EPR dosimetry can be improved by meticulous selection of measurement conditions, i.e., radiation fields and detector positions, ensuring accurate calculation of doses delivered to the dosimeters.