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1.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 38(6): 355-361, nov.-dic. 2019. ilus, tab
Article in Spanish | IBECS | ID: ibc-191699

ABSTRACT

OBJETIVO: El factor inducible para hipoxia (HIF-1) tiene un papel crítico en la homeostasis del oxígeno y es un activador transcripcional de angiogénesis, eritropoyesis, hierro y metabolismo de glucosa. La tasa de metabolismo de glucosa aumenta en algunos tumores a través de HIF-1alfa. Nuestro objetivo es evaluar la relación entre hipoxia en el cáncer colorrectal, los parámetros de PET, el tamaño del tejido necrótico y los factores pronósticos patológicos mediante el uso de HIF-1alfa. MATERIALES/MÉTODOS: 70 pacientes (28 mujeres/42 hombres; promedio de edad: 63 años) diagnosticados con cáncer colorrectal mediante biopsia, se estadificaron con PET/TC preoperatoria y se operaron posteriormente. La puntuación de evaluación inmunohistoquímica se realizó de acuerdo con la expresión de HIF-1alfa nuclear, la intensidad y la densidad de tinción. El volumen metabólico tumoral (MTV), la glucólisis de lesión total (TLG) y el volumen tumoral (TV) se calculó utilizando el volumen de una fórmula elipsoide mediante las imágenes de TC y el porcentaje de necrosis tumoral (%TmNcr) se calculó por diferencia entre TV y MTV. RESULTADOS: Hubo una correlación positiva moderadamente significativa entre el SUVmáx del tumor y TV y el %TmNcr (r=0,403, p = 0,001 y r=0,5, p = 0,0001, respectivamente). No hubo una relación estadísticamente significativa entre niveles de expresión de HIF-1alfa y SUVmáx tumoral, TLG, MTV, TV, %TmNcr, estadio tumoral, invasión linfovascular, invasión perineural y afectación ganglionar extracapsular/capsular. Por otro lado, se observó una fuerte tinción inmunohistoquímica nuclear en las células tumorales adyacentes al borde invasivo, las células inflamatorias. Aunque no fue estadísticamente significativa, se observó una tinción nuclear moderada o fuerte en el 64,9% de los pacientes metastásicos. CONCLUSIÓN: Aunque la presencia de una correlación positiva entre SUVmáx tumoral y el % de TmNcr muestra que hay células hipóxicas en tejido canceroso con una alta captación de FDG, no se demostró ninguna relación entre la presencia de HIF-1alfa y el incremento metabólico de glucosa y los factores patológicos del tumor. La fuerte tinción inmunohistoquímica nuclear en células tumorales adyacentes a las células inflamatorias y de borde invasivas nos hace pensar que HIF-1alfa desempeña un papel en el área de invasión del microambiente tumoral


AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism. Glucose metabolism rate is increased in some tumours via HIF-1alfa. Our aim is to evaluate the relationship between hypoxia in colorectal cancer, PET parameters, necrotic tissue size and pathologic prognostic factors via using HIF-1alfa. MATERIALS/METHODS: 70 patients (28 female/42 male; median age: 63 years) who were diagnosed with colorectal cancer via biopsy were staged with preoperative PET/CT and operated subsequently. Immunohistochemical evaluation scoring was done according to nuclear HIF-1alfa expression, staining density and intensity. Metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour volume (TV) were calculated by using volume of an ellipsoid formula via CT images, and percentage of tumour necrosis (%TmNcr) that was calculated by the difference between TV and recorded MTV. RESULTS: There was a moderately meaningful positive correlation between tumour SUVmax and TV and %TmNcr (r=0.403, p = 0.001 and r=0.500, p = 0.0001, respectively). There were no statistically significant relationships between HIF-1alfa expression levels and tumour SUVmax, TLG, MTV, TV, %TmNcr, tumour stage, lymphovascular invasion, perineural invasion and extracapsular/capsular lymph node involvement. On the other hand, strong nuclear immunohistochemical staining was seen in tumour cells adjacent to invasive border, inflammatory cells. Although not statistically significant, moderate or strong nuclear staining were seen in 64.9% of metastatic patients. CONCLUSION: Although the presence of a positive correlation between tumour SUVmax and %TmNcr shows that there are hypoxic cells in cancer tissue with high FDG uptake, the relationship between the presence of HIF-1alfa and enhanced glucose metabolism and pathological prognostic factors of tumour was not shown. Strong nuclear immunohistochemical staining in tumour cells adjacent to invasive border and inflammatory cells leads us to believe that HIF-1alfa plays a role in the invasion area of tumour microenvironment


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Colorectal Neoplasms/chemistry , Colorectal Neoplasms/diagnostic imaging , Fluorodeoxyglucose F18 , Hypoxia-Inducible Factor 1, alpha Subunit/analysis , Positron Emission Tomography Computed Tomography , Positron Emission Tomography Computed Tomography/methods
2.
Article in English, Spanish | MEDLINE | ID: mdl-31672495

ABSTRACT

AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism. Glucose metabolism rate is increased in some tumours via HIF-1α. Our aim is to evaluate the relationship between hypoxia in colorectal cancer, PET parameters, necrotic tissue size and pathologic prognostic factors via using HIF-1α. MATERIALS/METHODS: 70 patients (28 female/42 male; median age: 63 years) who were diagnosed with colorectal cancer via biopsy were staged with preoperative PET/CT and operated subsequently. Immunohistochemical evaluation scoring was done according to nuclear HIF-1α expression, staining density and intensity. Metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour volume (TV) were calculated by using volume of an ellipsoid formula via CT images, and percentage of tumour necrosis (%TmNcr) that was calculated by the difference between TV and recorded MTV. RESULTS: There was a moderately meaningful positive correlation between tumour SUVmax and TV and %TmNcr (r=0.403, p=0.001 and r=0.500, p=0.0001, respectively). There were no statistically significant relationships between HIF-1α expression levels and tumour SUVmax, TLG, MTV, TV, %TmNcr, tumour stage, lymphovascular invasion, perineural invasion and extracapsular/capsular lymph node involvement. On the other hand, strong nuclear immunohistochemical staining was seen in tumour cells adjacent to invasive border, inflammatory cells. Although not statistically significant, moderate or strong nuclear staining were seen in 64.9% of metastatic patients. CONCLUSION: Although the presence of a positive correlation between tumour SUVmax and %TmNcr shows that there are hypoxic cells in cancer tissue with high FDG uptake, the relationship between the presence of HIF-1α and enhanced glucose metabolism and pathological prognostic factors of tumour was not shown. Strong nuclear immunohistochemical staining in tumour cells adjacent to invasive border and inflammatory cells leads us to believe that HIF-1α plays a role in the invasion area of tumour microenvironment.


Subject(s)
Colorectal Neoplasms/chemistry , Colorectal Neoplasms/diagnostic imaging , Fluorodeoxyglucose F18 , Hypoxia-Inducible Factor 1, alpha Subunit/analysis , Positron Emission Tomography Computed Tomography , Radiopharmaceuticals , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Positron Emission Tomography Computed Tomography/methods
3.
Niger J Clin Pract ; 18(4): 563-8, 2015.
Article in English | MEDLINE | ID: mdl-25966734

ABSTRACT

Reports in the literature about the craniofacial characteristics of patients with class II division 2 malocclusions show a lot of different patterns accompanied by palatally displaced upper incisors, congenital missing teeth, polydiastema, fusion, germination, tooth impaction, peg-shaped lateral incisors, persistent teeth, hypodontia, persistent deciduous teeth, transpositions, and supernumerary teeth. The following case report focuses on the description of the clinical characteristics observed on a patient with a very unusual conjunction of dental and skeletal anomalies mentioned above, as well as a literature review on the related issues. Extra-intra-oral examinations, radiographic evaluations, orthodontic consultation, and reviewing the literature concluded that this nonsyndromic patient that refused to receive all dental treatment approaches is special with its uniqueness.


Subject(s)
Abnormalities, Multiple , Malocclusion, Angle Class II/diagnostic imaging , Tooth Abnormalities/diagnostic imaging , Tooth, Supernumerary/diagnostic imaging , Adolescent , Humans , Male , Malocclusion, Angle Class II/etiology , Radiography , Tooth Abnormalities/complications
4.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 34(1): 53-55, ene.-feb. 2015. ilus
Article in English | IBECS | ID: ibc-132208

ABSTRACT

NUT midline carcinoma (NMC) is a newly defined and lethal cancer with aggressive course. It mostly affects children and young adults. Diagnosis is confirmed with the evidence of BRD4-NUT mutation on the chromosome 15q14 by fluorescence in situ hybridization. Use of 18F-FDG PET/CT in NMC patients is very limited in the literature. In this report, we describe a 7-year-old boy with the diagnosis of NMC who was scanned with 18F-FDG PET/CT for staging and treatment response evaluation after the chemotherapy. It was disseminated and had moderate FDG avidity in the initial scan and showed progression after 4 cycles of chemotherapy. We also reviewed the literature related to 18F-FDG PET/CT in staging and assessment of chemotherapy response of NMC (AU)


El Carcinoma de línea media - NUT (NMC), es un cáncer letal recientemente definido con un curso agresivo. Afecta sobre todo a niños y jóvenes adultos. El diagnóstico se confirma con la evidencia de la mutación de BRD4-NUT en el cromosoma 15q14 mediante hibridación fluorescente in situ. El uso de 18F-FDG PET/TAC en pacientes con NMC está muy limitado en la bibliografía. En este informe describimos un niño de 7 años con un diagnóstico de NMC que ha sido explorado con 18F-FDG PET/TAC para la preparación y evaluación de la respuesta a la quimioterapia. El NMC estaba diseminado y mostraba una moderada captación de FDG en una exploración inicial y presentando una progresión después de 4 ciclos de quimioterapia. También analizamos la bibliografía relacionada con 18F-FDG PET/TAC en la estadificación y evaluación de la repuesta a la quimioterapia del NMC (AU)


Subject(s)
Humans , Male , Child , Carcinoma/diagnosis , Carcinoma/drug therapy , Neoadjuvant Therapy/instrumentation , Neoadjuvant Therapy/methods , Fluorodeoxyglucose F18 , Fluorodeoxyglucose F18/metabolism , In Situ Hybridization, Fluorescence , Neoplasm Staging/methods , Neoplasm Staging , Carcinoma/physiopathology , Carcinoma , Dose-Response Relationship, Radiation , Positron-Emission Tomography/instrumentation , Positron-Emission Tomography/methods
5.
Rev Esp Med Nucl Imagen Mol ; 34(1): 53-5, 2015.
Article in English | MEDLINE | ID: mdl-25304847

ABSTRACT

NUT midline carcinoma (NMC) is a newly defined and lethal cancer with aggressive course. It mostly affects children and young adults. Diagnosis is confirmed with the evidence of BRD4-NUT mutation on the chromosome 15q14 by fluorescence in situ hybridization. Use of (18)F-FDG PET/CT in NMC patients is very limited in the literature. In this report, we describe a 7-year-old boy with the diagnosis of NMC who was scanned with (18)F-FDG PET/CT for staging and treatment response evaluation after the chemotherapy. It was disseminated and had moderate FDG avidity in the initial scan and showed progression after 4 cycles of chemotherapy. We also reviewed the literature related to (18)F-FDG PET/CT in staging and assessment of chemotherapy response of NMC.


Subject(s)
Abdominal Neoplasms/diagnostic imaging , Bone Neoplasms/secondary , Carcinoma/diagnostic imaging , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Liver Neoplasms/secondary , Neoadjuvant Therapy , Neoplasm Staging/methods , Positron Emission Tomography Computed Tomography/methods , Radiopharmaceuticals , Thoracic Neoplasms/diagnostic imaging , Abdominal Neoplasms/drug therapy , Abdominal Neoplasms/genetics , Abdominal Neoplasms/radiotherapy , Bone Neoplasms/diagnostic imaging , Carcinoma/drug therapy , Carcinoma/genetics , Carcinoma/radiotherapy , Carcinoma/secondary , Child , Disease Progression , Humans , Liver Neoplasms/diagnostic imaging , Male , Nuclear Proteins/genetics , Oncogene Proteins, Fusion/genetics , Palliative Care , Thoracic Neoplasms/drug therapy , Thoracic Neoplasms/genetics , Thoracic Neoplasms/radiotherapy
6.
Sarcoidosis Vasc Diffuse Lung Dis ; 30(1): 52-9, 2013 Mar.
Article in English | MEDLINE | ID: mdl-24003535

ABSTRACT

OBJECTIVES: To determine the performance of diffusion-weighted magnetic resonance imaging in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy. MATERIALS AND METHODS: Forty-four mediastinal-hilar lymphadenopathy were examined in 27 patients with T1- and T2-weighted conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm2 values and apparent diffusion coefficients (ADCs) were calculated. The statistical significance of differences between measurements was tested using the Student-t test. RESULTS: The ADC value in the lymphoma group was lower than in the sarcoidosis group, and the difference was statistically significant (p < 0.001). By using the cut-off value of 1.266 x 10(-3) mm2/s, ADC had a sensitivity of 100%, specificity of 81%, positive predictive value of 100%, and negative predictive value of 77% for the differentiation of lymphoma and sarcoidosis. With the cut-off value of 1,97 x 10(-3) mm2/s, ADC had a sensitivity of 50%, specificity of 99.4%, positive predictive value of 68%, and negative predictive value of 91%. CONCLUSIONS: Diffusion-weighted imaging may be useful besides other modalities in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy.


Subject(s)
Diffusion Magnetic Resonance Imaging , Lymphatic Diseases/diagnosis , Lymphoma/diagnosis , Mediastinal Diseases/diagnosis , Sarcoidosis/diagnosis , Adult , Diagnosis, Differential , Female , Hodgkin Disease/diagnosis , Humans , Lymphatic Diseases/etiology , Lymphoma/complications , Male , Mediastinal Diseases/etiology , Middle Aged , ROC Curve , Sarcoidosis/complications , Sensitivity and Specificity , Young Adult
8.
Acta Chir Belg ; 112(6): 426-31, 2012.
Article in English | MEDLINE | ID: mdl-23397824

ABSTRACT

BACKGROUND: Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem. Trolox effectively prevents lipid peroxidation in oxidative stress and protects cell injury. The aim of this study is to investigate the effect of Trolox alone on the intestinal ischemia-reperfusion injury in strangulation ileus model, which has not been investigated previously. METHODS: Twenty-eight Sprague-Dawley rats randomly divided into four groups were used. Group Laparotomy + Physiological Saline underwent laparotomy and was administered physiological saline; Group Laparotomy + Trolox was administered Trolox. Group Strangulation + Physiological Saline was administered physiological saline before reperfusion following strangulation ileus; Group Strangulation + Trolox was administered Trolox. RESULTS: Histopathological study was evaluated and catalase, malondialdehyde, superoxide dismutase measurements were performed in intestinal samples. Serum biochemistry parameters were evaluated. The higher grade (grade > or = 2) was significantly observed to decrease in Group Strangulation + Trolox when compared with Group Strangulation + Physiological Saline (p = 0.04). In Group Laparotomy + Trolox, when compared with Group Laparotomy + Physiological Saline, the higher grade was found to be significantly lower (p = 0.03). The catalase values were found to be significantly lower in Group Strangulation + Trolox, when compared with Group Strangulation + Physiological Saline, and in Group Laparotomy + Trolox, when compared with Group Laparotomy + Physiological Saline (p < 0.01). CONCLUSIONS: Trolox is a powerful antioxidant as well as effectively prevents ischemia-reperfusion injury of the strangulated intestine segment.


Subject(s)
Antioxidants/therapeutic use , Chromans/therapeutic use , Animals , Antioxidants/pharmacology , Chromans/pharmacology , Female , Ileus , Intestines/blood supply , Lipid Peroxidation/drug effects , Rats , Rats, Sprague-Dawley , Reactive Oxygen Species/pharmacology , Reperfusion Injury/physiopathology , Reperfusion Injury/prevention & control
9.
J Perinatol ; 32(1): 72-4, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22202955

ABSTRACT

Cytomegalovirus (CMV) infection is the most common intrauterine and perinatal viral infection. Postnatal CMV infection is acquired mainly from breast milk and may cause severe illness in preterm infants. We report an extremely low birth weight infant who presented with a sepsis-like syndrome and multiple organ involvement, notably hepatitis and pneumonitis, and treated with ganciclovir without adverse effect or relapse.


Subject(s)
Cytomegalovirus Infections/transmission , Infant, Extremely Low Birth Weight , Infectious Disease Transmission, Vertical , Milk, Human/virology , Cytomegalovirus/genetics , Cytomegalovirus/isolation & purification , Cytomegalovirus Infections/diagnosis , DNA, Viral/analysis , Female , Humans , Infant, Newborn , Male , Young Adult
11.
Gynecol Obstet Invest ; 64(1): 36-9, 2007.
Article in English | MEDLINE | ID: mdl-17202822

ABSTRACT

Most clear cell neoplasms of the ovaries are carcinomas; benign and borderline clear cell tumors are uncommon. To date, only 12 cases of benign clear cell adenofibroma have been reported in the literature. Here we report a case of benign clear cell adenofibroma of the left ovary in a 51-year-old postmenopausal woman. Histological examination revealed widely spaced simple glands embedded in a dense fibrous stroma. The glands were lined by one to two layers of cells with abundant clear cytoplasm. The nuclei were bland and uniform in size and shape. There was minimal cytologic atypia in some areas. In this article we discussed the criteria for the diagnosis of benign and borderline clear cell adenofibromas and reviewed the literature.


Subject(s)
Adenofibroma/pathology , Adenofibroma/surgery , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Adenofibroma/diagnosis , Biopsy, Needle , Female , Follow-Up Studies , Humans , Hysterectomy/methods , Immunohistochemistry , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/diagnosis , Ovariectomy/methods , Pelvic Pain/diagnosis , Pelvic Pain/etiology , Postmenopause , Risk Assessment , Treatment Outcome , Uterine Hemorrhage/diagnosis , Uterine Hemorrhage/etiology
12.
Neurol India ; 54(1): 94-6, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16679656

ABSTRACT

Subclavian steal syndrome (SSS) is a clinical entity characterized by brachial and basilar insufficiency as a result of critical proximal subclavian artery stenosis or occlusion. We report a patient of giant hypervascular thyroid nodule presenting with features of SSS. The left hand ischemia and symptoms of vertebro-basilar artery in our patient were probably related to stealing of blood by the hypervascular thyroid nodule from the subclavian artery. The patient was relieved of the symptoms upon percutaneous subclavian stent placement.


Subject(s)
Subclavian Steal Syndrome/diagnosis , Thyroid Nodule/diagnostic imaging , Adult , Female , Humans , Radiography , Stents , Subclavian Artery/pathology , Subclavian Steal Syndrome/diagnostic imaging , Subclavian Steal Syndrome/therapy , Thyroid Nodule/etiology
13.
Eur J Radiol ; 51(3): 234-40, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15294330

ABSTRACT

PURPOSE: The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. MATERIALS AND METHODS: Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P < 0.05 was considered significant. RESULTS: The addition of the DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. CONCLUSION: The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts.


Subject(s)
Cerebellar Diseases/diagnosis , Cranial Nerves/pathology , Image Enhancement/methods , Imaging, Three-Dimensional/methods , Magnetic Resonance Imaging/methods , Abducens Nerve/pathology , Adult , Aged , Artifacts , Cerebellar Neoplasms/diagnosis , Cerebellopontine Angle/pathology , Cerebrospinal Fluid , Contrast Media , Ear, Inner/innervation , Endolymph , Facial Nerve/pathology , Female , Gadolinium DTPA , Humans , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/instrumentation , Male , Middle Aged , Trigeminal Nerve/pathology , Vestibulocochlear Nerve/pathology
14.
Rheumatology (Oxford) ; 43(5): 587-91, 2004 May.
Article in English | MEDLINE | ID: mdl-14734790

ABSTRACT

OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic systemic disease, which can involve multiple organs such as kidney, skin and brain. Lung is another organ that can be affected. A number of pulmonary complications including pleuritis, pneumonitis, infectious pneumonia, pulmonary haemorrhage, pulmonary hypertension and pneumothorax have been reported in patients with SLE. Pulmonary involvement is relatively frequent in adult patients; it has infrequently been reported in children with SLE. However, pulmonary manifestations may be an initial and/or life-threatening complication of SLE in children. In this paper we aim to emphasize the pulmonary involvement in childhood-onset SLE via description of our patients. METHODS: The patients, who were diagnosed with SLE at the Children's Hospital of Ankara University Medical School between 1993 and 2002, were retrospectively evaluated for evidence of pulmonary involvement. All patients fulfilled at least four of the classification criteria of the American Rheumatism Association. Using a standardized form, we obtained data regarding the age, sex and presenting complaints of the patients, previous therapies given, clinical and laboratory features, treatment and outcome. Informed consent was obtained from all patients. RESULTS: During the 10-yr study period, 16 patients were diagnosed with childhood-onset SLE. Five of them (31%) had pulmonary involvement including acute lupus pneumonitis, invasive pulmonary aspergillosis, cytomegalovirus pneumonia and pulmonary haemorrhage (in two patients). These 5 patients with lupus lung disease are presented in more detail.


Subject(s)
Lung Diseases/etiology , Lupus Erythematosus, Systemic/complications , Adolescent , Age of Onset , Child , Female , Humans , Lung Diseases/diagnosis , Lung Diseases/diagnostic imaging , Retrospective Studies , Tomography, X-Ray Computed
16.
Surg Radiol Anat ; 24(5): 324-6, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12497225

ABSTRACT

We present a 50-year-old woman with agenesis of the sphenoid sinuses. She was referred for evaluation of the aeration status of the sphenoid sinus and related nasal structures before endoscopic transsphenoidal hypophysectomy for pituitary microadenoma. Axial and coronal computed tomography (CT) scans revealed absence of the sphenoid sinuses and the right posterior ethmoidal cell. Agenesis of sphenoid sinuses documented using CT scans is uncommon. One case with a history of Hand-Schuller-Christian disease has been reported in the English language literature. In the case reported here agenesis of the sphenoid sinuses was not accompanied by craniofacial anomaly or skeletal disease.


Subject(s)
Sphenoid Sinus/abnormalities , Tomography, X-Ray Computed , Female , Humans , Middle Aged , Sphenoid Sinus/diagnostic imaging
18.
Bone Marrow Transplant ; 30(1): 45-7, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12105777

ABSTRACT

There is an appreciable mortality associated with BMT in patients with SCID and advanced BCG infection. We present a girl with T-B+ SCID complicated by spina ventosa and disseminated BCG osteitis after receiving a fully matched sibling marrow transplant. Considerable progression characterised by two clinical activations and multiple pleural and perivertebral abscess formations occurred with conventional anti-mycobacterial chemotherapy. She finally recovered with full immune reconstitution after BMT and intensive treatment comprising five conventional and alternative agents that she received for 36 months. No side-effects and/or complications have been seen other than hearing loss.


Subject(s)
BCG Vaccine/adverse effects , Bone Marrow Transplantation/adverse effects , Severe Combined Immunodeficiency/complications , Tuberculosis/drug therapy , Tuberculosis/etiology , Antibiotics, Antitubercular/administration & dosage , Antineoplastic Agents/administration & dosage , Bone Marrow Transplantation/methods , Drug Therapy, Combination , Female , Humans , Infant , Mycobacterium tuberculosis , Severe Combined Immunodeficiency/therapy , Treatment Outcome , Tuberculosis/diagnosis
19.
Auris Nasus Larynx ; 28(4): 361-3, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11694384

ABSTRACT

Pneumatization of the inferior turbinate is an extremely rare intranasal anatomical variation. Only a few cases have been reported yet. In this paper we present two cases, one unilateral and one bilateral case with pneumatization of the inferior turbinate.


Subject(s)
Tomography, X-Ray Computed , Turbinates/abnormalities , Adult , Female , Humans , Nasal Obstruction/congenital , Nasal Obstruction/diagnostic imaging , Nasal Obstruction/surgery , Nasal Septum/abnormalities , Nasal Septum/diagnostic imaging , Nasal Septum/surgery , Rhinoplasty , Turbinates/diagnostic imaging , Turbinates/surgery
20.
Pediatr Int ; 43(4): 385-90, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11472584

ABSTRACT

BACKGROUND: Nasopharyngeal colonization plays an important role for infections caused by Streptococcus pneumoniae. Emergence of penicillin resistance in this organism has made it difficult to treat pneumococcal infections. The objectives of this study were to investigate the risk factors for nasopharyngeal colonization with S. pneumonia and for nasopharyngeal colonization with penicillin-resistant S. pneumoniae. METHODS: Three hundred children with or without evidence of infection were investigated for various risk factors. Streptococcus pneumoniae isolated from children's nasopharyngeal swabs were examined for penicillin susceptibility. RESULTS: Day-care attendance (odds ratio OR=2.82, P=0.003) and upper respiratory tract infection within the last month (OR=1.83, P=0.02), have been determined to be risk factors for S. pneumoniae carriage. The use of antibiotics within the last 3 months (OR=81.07, P<0.001), the presence of more than five people living in the house of the child (OR=6.63, P=0.03), and having a sibling under 5-years-old (OR=4.60, P=0.03) have been determined to be risk factors for penicillin-resistant S. pneumoniae carriage. CONCLUSION: Some children are inevitably exposed to and colonized with penicillin susceptible or resistant S. pneumoniae. Changes in day-care organizations, better living conditions, and restriction of antibiotic use seems to be useful precautions to prevent the emerging and colonization with penicillin-susceptible or -resistant S. pneumoniae.


Subject(s)
Carrier State , Pneumococcal Infections/epidemiology , Child , Child Day Care Centers , Child, Preschool , Female , Humans , Infant , Male , Penicillin Resistance , Risk Factors , Turkey/epidemiology
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