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1.
Hansen. int ; 49: 39416, 2024.
Article in Portuguese | LILACS, Sec. Est. Saúde SP, HANSEN, Hanseníase Leprosy, SESSP-ILSLPROD, Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1562288

ABSTRACT

Introdução: a hanseníase apresenta potencial incapacitante secundário às reações hansênicas. Existe considerável número de indivíduos com episódios recorrentes de reação durante o tratamento. Objetivo: identificar características clínicas e histopatológicas que diferenciem pacientes com reação hansênica ou não. Método: estudo prospectivo de julho/2015 a dezembro/2016, com avaliação de indivíduos com diagnóstico novo de hanseníase atendidos no serviço de dermatologia do Complexo Hospitalar Clementino Fraga, na cidade de João Pessoa, Paraíba, Brasil. Os sujeitos foram classificados segundo os critérios de Ridley-Jopling/Madrid e por classificação operacional. Realizaram exame histopatológico no momento do diagnóstico e após 12 meses, e reavaliados após 6 e 12 meses do diagnóstico. Resultados: o grupo sem reação apresentou maior número de lesões com nítida delimitação. Observou-se predomínio das formas multibacilares entre indivíduos com reação. Quanto ao grau de incapacidade, o grupo com reação apresentou maior número de indivíduos com grau de incapacidade maior que zero. No grupo sem reação, encontrou-se menor frequência de fatores predisponentes. Notou-se correlação positiva do índice baciloscópico de biópsia cutânea com a ocorrência de reações. Discussão: a ausência de delimitação periférica das lesões pode se correlacionar com o surgimento de reação hansênica. O predomínio de reação entre os indivíduos que apresentavam grau de incapacidade maior que zero sugere associação de deficiência física e doença multibacilar. A ausência de fatores predisponentes aponta menor risco de reação hansênica. Observou-se correlação positiva do índice baciloscópico da biópsia com a ocorrência das reações. Conclusão: a significativa prevalência de reações graves enfatizam a importância do estudo contínuo da hanseníase e a necessidade de identificar precocemente as características clínicas sugestivas de reações hansênicas.(AU)


Introduction: leprosy reactions have the potential to cause disabilities. Many individuals experience recurrent episodes of reaction during treatment. Objective:to identify clinical and histopathological characteristics that differentiate patients with leprosy reactions from those without leprosy reactions. Method: this is a prospective study conducted from July 2015 to December 2016, evaluating individuals newly diagnosed with leprosy and treated at the dermatology service of the Clementino Fraga Hospital Complex in João Pessoa, Paraíba, Brazil. The subjects were classified according to the Ridley-Jopling/Madrid criteria and operational classification. They underwent a histopathological examination at the time of diagnosis and 12 months later, and were reassessed 6 and 12 months after the diagnosis. Results: the group without a reaction had a greater number of lesions with clear delimitation. Individuals with a reaction showed a predominance of multibacillary forms. The group with a reaction had a greater number of individuals with a degree of disability greater than zero. A positive correlation was observed between the bacilloscopic index and the occurrence of reactions. Discussion: the lack of clear boundaries around the lesions may be linked to the onset of a leprosy reaction. The higher incidence of reactions in individuals with some degree of physical disability indicates a correlation between disability and multibacillary disease. Additionally, a positive correlation was found between the bacilloscopic index of the biopsy and the occurrence of reactions. Conclusion: the high incidence of severe reactions underscores the need for ongoing studies on leprosy and the identification of early clinical characteristics that suggest leprosy reactions.(AU)


Subject(s)
Humans , Male , Female , Leprosy/pathology , Leprosy/therapy , Brazil/epidemiology , Retrospective Studies
2.
An Bras Dermatol ; 88(1): 64-8, 2013.
Article in English | MEDLINE | ID: mdl-23539005

ABSTRACT

BACKGROUND: Weathering nodules of the ear are pale yellow, asymptomatic lesions which predominate on the helices of the ears. Although their pathogenesis remains unknown, there is an association with chronic exposure to ultraviolet radiation, age and thermal injuries. Few studies have been conducted to date, and these involved a very small number of patients. OBJECTIVE: Study the prevalence of weathering nodules of the ear in patients treated in the Dermatology Service of the State Civil Servant's Hospital of São Paulo, and evaluate their probable relationship with sun exposure, age and phototypes I and II. METHODS: Four hundred patients older than 20 years of age were examined between July 2008 and December 2008. A questionnaire evaluating age, sex, place of birth, origin, occupation and history of sun exposure was applied. All patients were examined and evaluated for the presence of lesions by only one person. RESULTS: The data showed that 155 (38.8%) patients had a lesion in at least one of the ears. The Chi-Square Test was used for the comparative analysis between the groups of patients with and without lesions. In the group of patients with lesions, 29% were 70 to 79 years old, 78.1% had a history of sun exposure and 45.1% belonged to FITZPATRICK skin phototypes I and II (p<0.05%). CONCLUSION: The findings suggest relevant prevalence, probable association with chronic sun exposure, advanced age and phototypes I and II.


Subject(s)
Ear Auricle/radiation effects , Radiation Injuries/etiology , Skin Diseases, Papulosquamous/etiology , Sunlight/adverse effects , Adult , Age Factors , Aged , Aged, 80 and over , Asymptomatic Diseases , Brazil/epidemiology , Chi-Square Distribution , Cross-Sectional Studies , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Prevalence , Radiation Injuries/diagnosis , Radiation Injuries/epidemiology , Skin Diseases, Papulosquamous/diagnosis , Skin Diseases, Papulosquamous/epidemiology , Skin Pigmentation , Young Adult
3.
An. bras. dermatol ; 88(1): 64-68, fev. 2013. tab, graf
Article in English | LILACS | ID: lil-667941

ABSTRACT

BACKGROUND: Weathering nodules of the ear are pale yellow, asymptomatic lesions which predominate on the helices of the ears. Although their pathogenesis remains unknown, there is an association with chronic exposure to ultraviolet radiation, age and thermal injuries. Few studies have been conducted to date, and these involved a very small number of patients. OBJECTIVE: Study the prevalence of weathering nodules of the ear in patients treated in the Dermatology Service of the State Civil Servant's Hospital of São Paulo, and evaluate their probable relationship with sun exposure, age and phototypes I and II. METHODS: Four hundred patients older than 20 years of age were examined between July 2008 and December 2008. A questionnaire evaluating age, sex, place of birth, origin, occupation and history of sun exposure was applied. All patients were examined and evaluated for the presence of lesions by only one person. RESULTS: The data showed that 155 (38.8%) patients had a lesion in at least one of the ears. The Chi-Square Test was used for the comparative analysis between the groups of patients with and without lesions. In the group of patients with lesions, 29% were 70 to 79 years old, 78.1% had a history of sun exposure and 45.1% belonged to FITZPATRICK skin phototypes I and II (p<0.05%). CONCLUSION: The findings suggest relevant prevalence, probable association with chronic sun exposure, advanced age and phototypes I and II. .


FUNDAMENTOS: Pápulas climáticas das orelhas são lesões assintomáticas de coloração amarelo-pálida que predominam na hélice das orelhas. Sua patogênese permanece desconhecida, no entanto é descrita a associação com exposição crônica à radiação ultravioleta, idade e injúrias térmicas. Poucos estudos foram realizados até o momento e os mesmos envolveram número muito reduzido de pacientes. OBJETIVO: Estudar a prevalência de pápulas climáticas das orelhas nos doentes atendidos no Serviço de Dermatologia no Hospital Servidor Estadual de São Paulo e avaliar a provável relação com exposição solar, idade e tipo de pele. MÉTODOS: Foram examinados 400 pacientes com idade superior a vinte anos no período compreendido entre os meses de julho de 2008 a dezembro de 2008. Foi aplicado questionário que avaliou idade, sexo, naturalidade, procedência, profissão e história de exposição solar Todos os sujeitos da pesquisa foram examinados por um único observador e avaliados quanto à presença de lesão. RESULTADOS: Os dados revelaram que 155 (38,8%) pacientes apresentavam lesão em pelo menos uma das orelhas. Foi utilizado o teste do Qui-Quadrado para análise comparativa entre o grupo de pacientes com e sem lesão. No grupo de pacientes com lesão 29% tinham idade entre 70 e 79 anos, 78,1% tinham história de exposição solar e 45,1% pertenciam ao fototipo I e II da classificação de FITZPATRICK (p<0,05%). CONCLUSÃO: Os achados sugerem prevalência relevante, provável associação ...


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Ear Auricle/radiation effects , Radiation Injuries/etiology , Skin Diseases, Papulosquamous/etiology , Sunlight/adverse effects , Age Factors , Asymptomatic Diseases , Brazil/epidemiology , Chi-Square Distribution , Cross-Sectional Studies , Diagnosis, Differential , Prevalence , Radiation Injuries/diagnosis , Radiation Injuries/epidemiology , Skin Pigmentation , Skin Diseases, Papulosquamous/diagnosis , Skin Diseases, Papulosquamous/epidemiology
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