ABSTRACT
We describe a 79-year-old female with a chronic venous ulceration infected by Staphylococcus aureus and Enterococcus faecalis and not responsive to conventional treatments. The patient was treated with Methyl-Aminolaevulinate Photodynamic Therapy (MAL-PDT). After four weeks the cutaneous swabs become negative and we observed a significant clinical improvement. Therefore we suppose that MALPDT could represent a valid therapeutic option in the treatment of infected chronic ulcers.
Subject(s)
Aminolevulinic Acid/analogs & derivatives , Anti-Bacterial Agents/therapeutic use , Photochemotherapy , Photosensitizing Agents/therapeutic use , Skin Ulcer/drug therapy , Skin Ulcer/microbiology , Administration, Topical , Aged , Aminolevulinic Acid/adverse effects , Aminolevulinic Acid/therapeutic use , Anti-Bacterial Agents/adverse effects , Female , Humans , Photochemotherapy/adverse effects , Photosensitizing Agents/adverse effects , Skin/microbiology , Skin/pathology , Treatment OutcomeABSTRACT
Pyoderma Gangrenosum (PG) is a rare ulcerative cutaneous condition with distinctive characteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease (Ulcerative Colitis and Crohn's disease). The features of PG are not specific histopathologically and for this reason diagnosis is based on clinical feature. There is no single successful treatment for PG. In fact certain type of lesions respond more readily to some therapies than others. Local treatments (advanced wound care, local corticosteroids, local immunomodulator agents) may be sufficient for some clinical features, while others may be required systemic therapy (corticosteroids, immunosuppressive therapy, intravenous immune globulins, TNF-alpha blocking agents). We present four cases of PG associated with inflammatory bowel diseases treated with different therapeutic approaches.
Subject(s)
Pyoderma Gangrenosum , Adrenal Cortex Hormones/therapeutic use , Adult , Dermatologic Agents/therapeutic use , Female , Humans , Immunoglobulins, Intravenous/therapeutic use , Immunosuppressive Agents/therapeutic use , Inflammatory Bowel Diseases/complications , Male , Middle Aged , Pyoderma Gangrenosum/complications , Pyoderma Gangrenosum/diagnosis , Pyoderma Gangrenosum/therapy , Tumor Necrosis Factor-alpha/antagonists & inhibitorsABSTRACT
We described a case report of a 36-year-old woman with a 10-year-history of idiopathic CD4+ T-lymphocitopenia and Kaposi's sarcoma HHV8+ who developed recurrent pleural effusion. Laboratory and instrumental tests with morphologic, immunophenotypic and molecular analysis of pleural sediment suggest us the diagnosis of primary effusion lymphoma (PEL). The term primary effusion lymphoma defines an extranodal non-Hodgkin's lymphoma HHV8-related, usually classified as a B-cell lymphoma, that grows in liquid-phase within body cavities. The case reported by the Authors appears to be of great interest for its epidemiological and clinical features.
