ABSTRACT
A total of eight solvent systems used for the separation of 1,4-benzodiazepine mixtures were investigated. The classification of solvent systems was carried out by the numerical taxonomy technique. The selection of optimum solvent system was accomplished on the basis of information quantity and objective function. The method was found to be a rapid and efficient tool in the choice of optimum system solvent.
Subject(s)
Solvents/analysis , Chromatography, Thin Layer/methods , Mathematics , Solvents/classificationABSTRACT
The synthesis of the indomethacin (1H-indole-3-acetic acid, 1(4-chlorobenzoyl)-5-methoxy-2-methyl) was achieved through a new method, which reduces some stages from the previous methods. Both the structure of the finished product and the structures of the intermediaries were investigated by chromatographic methods (TLC, chromatography on column, GC-MSD) and spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR). The chromatographic and spectroscopic studies proved that these had a special analytical value and they serve to control synthesis and to identify the compounds in all the stages of the process.
Subject(s)
Indomethacin/chemical synthesis , Chromatography/methods , Gas Chromatography-Mass Spectrometry , Indomethacin/analysis , Indomethacin/chemistry , Spectrum Analysis/methodsABSTRACT
This research presents the results obtained from the separation, identification and quantitative determination of free amino acids from Gingko biloba and Hedera helix leaf extracts, using three modern techniques: thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry. The presence of the determined amino acids explains the utilisation of G. biloba and H. helix leaf extracts in cosmetic and pharmaceutical products.
