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1.
Proc Biol Sci ; 288(1956): 20210881, 2021 08 11.
Article in English | MEDLINE | ID: mdl-34375559

ABSTRACT

Food limitation is a universal stressor for wildlife populations and is increasingly exacerbated by human activities. Anthropogenic environmental change can significantly alter the availability and quality of food resources for reservoir hosts and impact host-pathogen interactions in the wild. The state of the host's nutritional reserves at the time of infection is a key factor influencing infection outcomes by altering host resistance. Combining experimental and model-based approaches, we investigate how an environmental stressor affects host resistance to West Nile virus (WNV). Using American robins (Turdus migratorius), a species considered a superspreader of WNV, we tested the effect of acute food deprivation immediately prior to infection on host viraemia. Here, we show that robins food deprived for 48 h prior to infection, developed higher virus titres and were infectious longer than robins fed normally. To gain an understanding about the epidemiological significance of food-stressed hosts, we developed an agent-based model that simulates transmission dynamics of WNV between an avian host and the mosquito vector. When simulating a nutritionally stressed host population, the mosquito infection rate rose significantly, reaching levels that represent an epidemiological risk. An understanding of the infection disease dynamics in wild populations is critical to predict and mitigate zoonotic disease outbreaks.


Subject(s)
Culex , Culicidae , Songbirds , West Nile Fever , West Nile virus , Animals , Humans , Insect Vectors , West Nile Fever/epidemiology , West Nile Fever/veterinary
2.
J Immunol ; 167(3): 1703-11, 2001 Aug 01.
Article in English | MEDLINE | ID: mdl-11466394

ABSTRACT

Asthma, a chronic inflammatory disease characterized by intermittent, reversible airflow obstruction and airway hyperresponsiveness (AHR), is classically characterized by an excess of Th2 cytokines (IL-13, IL-4) and depletion of Th1 cytokines (IFN-gamma, IL-12). Recent studies indicating an important role for Th1 immunity in the development of AHR with allergic inflammation suggest that Th1/Th2 balance may be important in determining the association of AHR with allergic inflammation. We hypothesized that administration of pentoxifylline (PTX), a phosphodiesterase inhibitor known to inhibit Th1 cytokine production, during allergen (OVA) sensitization and challenge would lead to attenuation of AHR in a murine model of allergic pulmonary inflammation. We found that PTX treatment led to attenuation of AHR when administered at the time of allergen sensitization without affecting other hallmarks of pulmonary allergic inflammation. Attenuation of AHR with PTX treatment was found in the presence of elevated bronchoalveolar lavage fluid levels of the Th2 cytokine IL-13 and decreased levels of the Th1 cytokine IFN-gamma. PTX treatment during allergen sensitization leads to a divergence of AHR and pulmonary inflammation following allergen challenge.


Subject(s)
Allergens/administration & dosage , Allergens/immunology , Bronchial Hyperreactivity/immunology , Lung/pathology , Pentoxifylline/administration & dosage , Respiratory Hypersensitivity/immunology , Respiratory Hypersensitivity/pathology , Aerosols , Animals , Bronchial Hyperreactivity/prevention & control , Bronchoalveolar Lavage Fluid/immunology , Cytokines/biosynthesis , Drug Administration Schedule , Female , Injections, Intraperitoneal , Interphase/immunology , Lung/drug effects , Lung/immunology , Lymphocyte Activation/drug effects , Lymphocytes/drug effects , Lymphocytes/immunology , Lymphocytes/metabolism , Mice , Mice, Inbred BALB C , NF-kappa B/metabolism , Ovalbumin/administration & dosage , Ovalbumin/immunology , Spleen/cytology , Spleen/immunology , Thorax
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