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Mannose-binding lectin (MBL2) polymorphisms and inflammation in hypertensive patients.

Schreiber, R; Campos-Coelho, A V; Brandão, L; Guimarães, R L; Kamada, A J; Ferreira-Sae, M C; Matos-Souza, J R; Cipolli, J A; de Lima-Filho, J L; Crovella, S; Nadruz, W.

Int J Immunogenet ; 38(6): 525-7, 2011 Dec.

Article in English | MEDLINE | ID: mdl-21895981

ABSTRACT

We investigated the possible role of Mannose binding lectin 2 (MBL2) functional polymorphisms in the prevalence of hypertension and hypertensive end-organ damage in 300 hypertensive patients and 313 normotensive individuals from Southern Brazil. Hypertensive subjects with MBL2 AO/OO genotypes presented lower C-reactive protein levels than AA individuals and consequently lower inflammatory status.

Subject(s)

Genetic Predisposition to Disease , Hypertension/complications , Hypertension/genetics , Inflammation/complications , Inflammation/genetics , Mannose-Binding Lectin/genetics , Polymorphism, Single Nucleotide/genetics , Brazil , C-Reactive Protein/metabolism , Female , Humans , Male , Middle Aged

ABSTRACT

Subject(s)

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