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Trials ; 20(1): 199, 2019 Apr 05.
Article in English | MEDLINE | ID: mdl-30953544

ABSTRACT

BACKGROUND: Cognitive deficits are core symptoms of schizophrenia that occur from the early stages of the disorder. There is reliable evidence that cognitive deficits are associated with outcomes in schizophrenia; thus, early treatment could be particularly important. Studies with different neuromodulation techniques involving subjects with schizophrenia suggest that application of transcranial direct current stimulation (tDCS) with inhibitory stimulation over the left temporo-parietal cortex and excitatory stimulation over the left dorsolateral prefrontal cortex could ameliorate positive, negative, and cognitive symptoms. The aim of the present study protocol is to evaluate the efficacy of tDCS in the treatment of cognitive symptomatology in the early stages of psychosis. METHODS/DESIGN: Seventy patients in the early stages of psychosis will be randomly allocated to receive 20 min of active 2-mA tDCS or sham stimulation once a day for 10 consecutive weekdays. The anode will be placed over the left dorsolateral prefrontal cortex and the cathode over the left temporo-parietal cortex. Neuropsychological and psychiatric assessments will be performed at baseline and at 1 and 3 months following the end of the intervention (sustained effect). DISCUSSION: The development and utilization of potentially effective neuroenhancement tools such as the non-invasive brain stimulation technique tDCS for the treatment and rehabilitation of cognitive impairment in the early stages of schizophrenia may contribute to improving outcomes of the disorder and eventually provide a further understanding of the nature of the complex and dynamic neural processes underlying those abnormalities. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03071484 . Registered on 7 March 2017.


Subject(s)
Cerebral Cortex/physiopathology , Cognition Disorders/therapy , Cognition , Schizophrenia/therapy , Schizophrenic Psychology , Transcranial Direct Current Stimulation , Adolescent , Adult , Brazil , Cognition Disorders/diagnosis , Cognition Disorders/physiopathology , Cognition Disorders/psychology , Double-Blind Method , Female , Humans , Male , Middle Aged , Parietal Lobe/physiopathology , Prefrontal Cortex/physiopathology , Randomized Controlled Trials as Topic , Schizophrenia/diagnosis , Schizophrenia/physiopathology , Temporal Lobe/physiopathology , Time Factors , Transcranial Direct Current Stimulation/adverse effects , Treatment Outcome , Young Adult
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