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1.
Ann Ig ; 23(4): 295-302, 2011.
Article in Italian | MEDLINE | ID: mdl-22026232

ABSTRACT

Patients have a privileged perspective on health care quality, thus it is important to obtain from them judgments about offered services. Currently, there are no well developed quality monitoring systems related to the patient's perspective, though Istat data sources would b helpful on this issues. We performed a descriptive analysis relating to the satisfaction degree of Italian population for hospital admissions between 1997and 2009. Data were taken from the Istat Multipurpose analysis on some aspect of daylife. Our results show a positive appraisal for medical and nursing assistance; however the rating for the quality of food is lower Our analysis would give a contribution to the appraisal of an outstanding dimension of patients' appraisal of quality of care among the Regions, by considering the implementation of devolution in healthcare since 2001.


Subject(s)
Delivery of Health Care/standards , Patient Satisfaction/statistics & numerical data , Hospitalization , Humans , Italy , Time Factors
2.
Ann Ig ; 17(4): 307-11, 2005.
Article in Italian | MEDLINE | ID: mdl-16156390

ABSTRACT

Sensorineural hearing loss (SNHL) is a serious public health problem which affects 1-3% per hundred live born babies in developed countries. The congenital cytomegalovirus (CMV) infection is its most important non-genetic cause. The evaluation of the effectiveness of future programs of anti-CMV vaccination requires an assessment of the present costs of SNHL. Direct costs for the Italian public system were calculated per prosthesis child until his full age and turned out to add up to 260,000 euro. Private costs are difficult to be assessed and anyhow are highly dependent from the socio-economic level. This preliminary assessment suggests that the vaccination would be cost-saving if SNHL cases due to congenital CMV were more than 21 per year, corresponding to a congenital infection prevalence higher than 0.21%o.


Subject(s)
Cytomegalovirus Infections/economics , Cytomegalovirus Infections/prevention & control , Cytomegalovirus Vaccines/economics , Health Care Costs , Hearing Loss, Sensorineural/economics , Hearing Loss, Sensorineural/prevention & control , Child , Child, Preschool , Costs and Cost Analysis , Cytomegalovirus Infections/congenital , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Vaccines/administration & dosage , Hearing Aids/economics , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/virology , Humans , Infant , Infant, Newborn , Italy
3.
Ann Ig ; 15(5): 443-56, 2003.
Article in Italian | MEDLINE | ID: mdl-14969297

ABSTRACT

Health care provider payment systems regulate the relationship between patients, providers, and third payers in order to maximise benefits and minimise costs of the whole health care system. Health care providers could be paid by a price or a fee for service, by capitation systems, or by reimbursement of production costs. It would be interesting to develop innovative payment systems aimed to the payment of the entire health care pattern of patients. This would be particularly desirable for certain health conditions where it is impossible to divide the health care delivery pattern into single health services e.g. psychiatric care, long term and rehabilitation care.


Subject(s)
Health Care Costs , Insurance, Health, Reimbursement , Comprehensive Health Care/economics , Comprehensive Health Care/organization & administration , Diagnostic Services/economics , Family Practice/economics , Hospital Administration/economics , Humans , Italy , Models, Econometric , Organizational Innovation
4.
Ann Ig ; 14(5): 409-18, 2002.
Article in Italian | MEDLINE | ID: mdl-12508449

ABSTRACT

Studies on efficacy (clinical trials) and efficiency (Cost Benefit) in health care are frequently disjoint and carried on by researchers with different background in distinct moments. The origin of this division can be found in the profound conviction existing in the healthcare researchers that efficiency and efficacy are distinct and distant concepts, the former pertaining to the economist, the latter to the clinician. Many are the factors at the basis of this separation which consequently lead to the divergence between the two sector of analysis; among those, probably the most relevant factor is the distinction, in the healthcare sector, between the consumer (the patient) and the purchaser (private and/or public insurance). In reality, the organizational evolution of the health care systems, the consciousness of the interdependency between health and economic benefits, and the progressive shortage of economic resources for the growing healthcare needs, require a major integration of analyses concerning efficacy and efficiency. On this line of thought is moving the operational research where models such as the Data Envelope Analysis and the Semi-Markov Decisional Models have been developed.


Subject(s)
Clinical Trials as Topic/standards , Cost-Benefit Analysis , Health Care Sector/standards , Operations Research , Quality of Health Care , Efficiency , Humans , Models, Theoretical , Quality of Health Care/economics , Research
7.
Article in English | MEDLINE | ID: mdl-11108445

ABSTRACT

We describe herein one case of systemic anaphylaxis due to the ingestion of an undefined mixture of pollens, sold as a dietary supplement. The patient, who suffered from rhinoconjunctivitis due to grass pollen (with sensitization to several trees), had a severe episode of anaphylaxis immediately after eating this health food. The episode required emergency care. We attempted to study the pollen mixture responsible, but no pollen granules could be identified. We prepared a solid phase with the pollen mixture, and we observed a RAST positivity with the patient's serum and pools of sera containing specific IgE to trees. Furthermore, a RAST-inhibition assay of the patient's serum showed highly positive results with grasses, birch, alder and Compositae. Therefore, we concluded that the pollen mixture contained determinants capable of cross-reacting with the patient's IgE. This case report is evidence of the possible risks due to the use of undefined herbal products by allergic patients.


Subject(s)
Allergens/immunology , Anaphylaxis/etiology , Food, Organic/adverse effects , Pollen/immunology , Humans , Male , Middle Aged , Phytotherapy
8.
Allergol. immunopatol ; 28(5): 287-289, sept. 2000.
Article in En | IBECS | ID: ibc-8582

ABSTRACT

A case of severe systemic reactions (intense itching, urticaria, confusion, blurred vision, transient loss of consciousness, sweating, tachycardia) after ingestion of raw or lightly-cooked onion is described. The patient, a 44-year-old woman, had no troubles with well-cooked onions. Differently from the cases of sensitivity to onion described in literature, this patient was monosensitized, being skin tests negative to pollens, inhalants and other foods. The patient had 3.7 kU/L of onion-specific segum IgE, as determined by REAST. The density of onion-specific IgE (calculated as percent ratio to total IgE) was 30.8%. The reactivity of patient's serum IgE towards thermolabile and thermostable components has been tested with unheated and heated (30' at 100 °C) onion extracts bound to polystyrene beads and tested in the RAST system. Unheated extract resulted positive in class 2, heated extract negative, demonstrating that this patients, differently from similar clinical cases described in literature, had IgE antibodies recognizing just thermolabile onion fraction. This is the first case described in literature of a monosensitization to the thermolabile component of onion, negative also to related foods (Liliacee) and characterized by severe systemic reactions. The importance of specific-IgE density (%) rather their absolute amount (kU/L) as parameter predictive for the clinical severity of allergic reactions is discussed (AU)


Historial: se describe un caso de graves reacciones sistémicas (picazón intensa, urticaria, confusión, vista borrosa, pérdida transitoria de la conciencia, transpira ción, taquicardia) como consecuencia de la ingestión de cebollas poco cocidas o crudas. El paciente, de sexo femenino y de 44 años de edad, no había experimentado trastorno al ingerir cebollas bien cocidas. Respecto a los casos de sensibilidad hacia la cebolla descritos en la literatura, esta paciente ha sido monosensibilizada, resultando negativa la prueba cutánea a los pólenes y otros inhalantes y alimentos.Métodos y resultados: en el suero de la paciente se detectó IgE específico frente a cebolla, mediante REAST, con un valor de 3,7 kU/L.La densidad de la IgE específica de la cebolla (calculado como razón porcentual del total de la IgE) ha sido 30,8 por ciento. La reactividad del suero de IgE del paciente hacia los componentes termolábiles y termoestables ha sido comprobada con extractos de cebolla calentados y no calentados (por 30 min a 100 °C) en perlas de poliestirol y probados con el sistema RAST.El extracto no calentado ha resultado positivo de clase 2 mientras que el extracto calentado dio negativo, lo que demuestra que estos pacientes, al contrario de casos clínicos similares descritos en la literatura, presentaban anticuerpos de la IgE que reconocían solamente la fracción termolábil de la cebolla.Conclusiones: este es el primer caso descrito en la literatura de monosensibilización al componente termolábil de la cebolla, negativo también en alimentos que pertenecen a la familia de las Liliáceas y caracterizado por graves reacciones sistémicas. La importancia de la densidad de la IgE específica ( por ciento) respecto a la cantidad absoluta (kU/L), como parámetro que prevé la gravedad clínica de las reacciones alérgicas, resulta controvertida. (AU)


Subject(s)
Adult , Female , Humans , Onions , Anaphylaxis , Immunoglobulin E , Skin Tests
10.
Allergol Immunopathol (Madr) ; 28(5): 287-9, 2000.
Article in English | MEDLINE | ID: mdl-11270091

ABSTRACT

A case of severe systemic reactions (intense itching, urticaria, confusion, blurred vision, transient loss of consciousness, sweating, tachycardia) after ingestion of raw or lightly-cooked onion is described. The patient, a 44-year-old woman, had no troubles with well-cooked onions. Differently from the cases of sensitivity to onion described in literature, this patient was monosensitized, being skin tests negative to pollens, inhalants and other foods. The patient had 3.7 kU/L of onion-specific segum IgE, as determined by REAST. The density of onion-specific IgE (calculated as percent ratio to total IgE) was 30.8%. The reactivity of patient's serum IgE towards thermolabile and thermostable components has been tested with unheated and heated (30' at 100 degrees C) onion extracts bound to polystyrene beads and tested in the RAST system. Unheated extract resulted positive in class 2, heated extract negative, demonstrating that this patients, differently from similar clinical cases described in literature, had IgE antibodies recognizing just thermolabile onion fraction. This is the first case described in literature of a monosensitization to the thermolabile component of onion, negative also to related foods (Liliacee) and characterized by severe systemic reactions. The importance of specific-IgE density (%) rather their absolute amount (kU/L) as parameter predictive for the clinical severity of allergic reactions is discussed.


Subject(s)
Anaphylaxis/etiology , Onions/adverse effects , Adult , Female , Humans , Immunoglobulin E/analysis , Skin Tests
12.
Tumori ; 84(3): 312-34, 1998.
Article in English | MEDLINE | ID: mdl-9678613

ABSTRACT

BACKGROUND: Data and statistics are presented on cancer death certification in Italy, updating previous publications covering the period 1955-1993. METHODS: Data for 1994 and the quinquennium 1990-94 subdivided into 30 cancer sites are presented in 8 tables, including age- and sex-specific absolute and percentage frequencies of cancer deaths, and crude, age-specific and age-standardized rates, at all ages and truncated for the 35-64 year age group. Trends in age-standardized rates for major cancer sites are plotted from 1955 to 1994. RESULTS: The age-standardized (world standard) death certification rates from all neoplasms steadily declined from the peak of 199.2/100,000 males in 1988 to 186.3 in 1994, and in females from 102.5 in 1989 to 98.6 in 1994. Ever larger was the decline in truncated rates, for males from the peak of 275.1/100,000 in 1983 to 223.2 (-19%) in 1994, and for females from 151.6/100,000 in 1987 to 136.4 (-10%). A major component of the favourable cancer mortality trends in males was lung cancer (accounting for 31,000 deaths in both sexes combined in 1994), whose overall age-standardized rates declined from 60.3 in 1987-89 to 54.6/100,000 males in 1994 (-9%), and from the peak of 96.7 in 1983 at ages 35 to 64 to 72.7 in 1994 (-25%). In contrast, female lung cancer rates have remained stable from 1992 onwards, but have increased from 7.2 to 7.7 at all ages and from 10.6 to 11.0 at age 35-64 between 1985-89 and 1990-94. These different trends in the two sexes reflect the patterns and trends in smoking among Italian males and females. CONCLUSIONS: Cancer mortality trends in Italy over the period 1990-94 were relatively favourable, mainly reflecting the decline in lung cancer rates in males, together with the persistent declines in gastric cancer in both sexes and in cervix uteri for women. Continuous advancements were registered for neoplasms amenable to treatment, essentially testicular cancer, Hodgkin's disease and childhood leukaemias. The major unfavourable trends were observed for non Hodgkin's lymphomas, and require therefore further monitoring, besides a clearer understanding of their determinants. Italy maintains an intermediate level of cancer mortality on a European scale, suggesting that further progress is possible, mostly for tobacco-related neoplasms in males.


Subject(s)
Neoplasms/mortality , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Italy/epidemiology , Male , Middle Aged , Mortality/trends , Prevalence , Sex Distribution
13.
Prenat Diagn ; 18(3): 255-66, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9556042

ABSTRACT

Chorionic villus sampling (CVS) was performed in 10,000 consecutive singleton pregnancies by a single principal operator, working in two institutions. The procedure was performed between 8 and 32 gestational weeks: transabdominal (TA) sampling was carried out in 8479 cases and transcervical (TC) in 1521. Patients were referred for chromosomal risk in 89.1 per cent of cases, Mendelian disorders in 10.5 per cent, and DNA investigations for paternity or infectious agents in 0.4 per cent of cases. The sampling success rate for both TA and TC techniques by the second insertion was 99.8 and 99.2 per cent, respectively. TA sampling succeeded in a higher number of cases at the first insertion (98 per cent vs. 86.8 per cent) and was associated with smaller samples (< 10 mg) in fewer cases (3.2 per cent vs. 4.9 per cent). Cytogenetic analysis was highly successful (99.4 per cent) and accurate; however, in one case a de novo structural rearrangement of chromosome I was not recognized. Mosaicism or rare trisomies were reported in 1.30 per cent of cases. Five diagnostic errors in DNA investigation (0.51 per cent) ended with the birth of affected fetuses. Fetal loss through 28 weeks' gestation in the pregnancies intended to continue was 2.58 per cent; the rate increased with maternal age (1.22 per cent at less than 30 years to 3.8 per cent at 40 years or more), while gestational age affected the abortion rate only at 8 weeks (odds ratio=2.22, P<0.05). Rates of premature delivery, low birth weight, and perinatal mortality did not differ from the Italian standards. By comparison with the Italian Birth Defects Registry data, no differences were found for the major malformations, including transverse limb reduction defects (TLRDs) (4.34 vs. 3.28 x 10,000). Total malformations and TLRDs did not show any pattern relation to either maternal age or gestational age.


Subject(s)
Chorionic Villi Sampling/statistics & numerical data , Fetal Diseases/epidemiology , Metabolism, Inborn Errors/epidemiology , Adult , Female , Gestational Age , Humans , Incidence , Italy/epidemiology , Karyotyping , Pregnancy , Pregnancy Outcome
15.
Ann Ist Super Sanita ; 32(4): 453-69, 1996.
Article in Italian | MEDLINE | ID: mdl-9382417

ABSTRACT

The geographical distribution of mortality rates from tumours of digestive tract in Italy is analyzed in this paper. The analysis is based on official mortality data collected by the National Institute of Statistics (ISTAT). Age-adjusted mortality rates for stomach cancer presented the highest values in some provinces of the North and the Center, and the lowest values in the South of Italy. A same geographical pattern was observed for men and women, and during the whole considered period. Colorectal cancer presented the highest rates in the North-West of the country, and in some provinces of Liguria and Tuscany. The lowes rates were observed in the South, particularly in Calabria and Sicily. Mortality for this cancer was positively associated with degree of urbanization. The geographical pattern remained fairly constant in time, but the North-South differences narrowed during the years 1980s. A similar geographical distribution, characterized by the highest mortality levels in the north-eastern regions of Italy, was observed for cancers of the oral cavity and pharynx, of the oesophagus, of the pancreas, and for male tumours of the liver. Female liver cancer presented, on the contrary, the highest mortality levels in the southern regions.


Subject(s)
Digestive System Neoplasms/mortality , Cluster Analysis , Female , Humans , Italy/epidemiology , Male , Retrospective Studies
16.
Stat Med ; 14(21-22): 2363-81, 1995.
Article in English | MEDLINE | ID: mdl-8711275

ABSTRACT

In the present paper a new shrinkage estimator of relative risk, useful in disease mapping, is compared with the empirical and full Bayes estimators, using death certificate data for lung cancer (males and females) and breast cancer (females) 1982-1988 in the Emilia-Romagna region (Italy). The estimates are obtained averaging the relative risks obtained from recursive partitioning of the set of observed values. The number of partitions is fixed in advance and behaves as a smoothing parameter, the lower the number the higher the degree of shrinkage toward the overall mean of the observed values.


Subject(s)
Cluster Analysis , Models, Statistical , Risk , Algorithms , Bayes Theorem , Breast Neoplasms/mortality , Confounding Factors, Epidemiologic , Data Interpretation, Statistical , Female , Humans , Italy/epidemiology , Logistic Models , Lung Neoplasms/mortality , Male
17.
Epidemiol Prev ; 19(63): 142-9, 1995 Jun.
Article in Italian | MEDLINE | ID: mdl-7641856

ABSTRACT

Methods for the analysis of the spatial aggregation of health events has received growing attention under the pressure of public opinion concern and as tools for the identification of potential risk sources, for monitoring relevant geographical areas and, finally, for public health decisions. The development of statistical methods for the detection and localization of spatial clusters has mainly concerned individual data. This paper is aimed at describing one of the methods proposed for the identification of clusters in the case of information at individual level and at presenting its extension to grouped data. This method, the surface density estimation method using the Kernel approach, offers remarkable advantages in terms of simplicity of implementation and flexibility, this latter being an extremely important characteristic in the case of exploratory analyses. For exemplification purposes, the density estimation method has been applied to individual data concerning the spatial distribution of cerebral tumors in Campi Bisenzio (FI) and to the distribution of gastric cancer mortality in the municipalities around Arezzo and Pesaro.


Subject(s)
Models, Statistical , Public Health , Brain Neoplasms/epidemiology , Female , Gastrointestinal Neoplasms/epidemiology , Health Status , Humans , Incidence , Italy/epidemiology , Male
18.
Epidemiol Prev ; 19(63): 132-41, 1995 Jun.
Article in Italian | MEDLINE | ID: mdl-7641855

ABSTRACT

The Italian Atlas of mortality at municipality level is the result of a research project coordinated by the Emilia-Romagna region and supported by the Health Ministry. To the realisation of this project have collaborated the Institute of Medical Statistics of Milano and the CILEA under the supervision of Prof. Cesare Cislaghi. Compared to previous equivalent products, this Atlas contains a number of methodological and content innovations. This was a consequence of the development of new statistical methods and the need of achieving different aims. First of all, the Atlas was aimed at describing the mortality at small area level, which is obtained via Kernel estimates; secondly, the objective was to identify suspect clusters of deaths which may suggest the existence of high risk areas. The Mortality Atlas is formed by 31 tables, one for each of the analysed cause of death; each table has a circular shape of 100 hundred kilometers radius and contains a variable number of municipalities; each municipality may be present in more than one circle. The Atlas is available on magnetic support and for each cause of death are provided several statistical analyses and indicators included in different files. One of these files can be directly used to build high quality maps using the graphical package MAPINFO.


Subject(s)
Cervical Atlas , Liver Cirrhosis/mortality , Neoplasms/mortality , Wounds and Injuries/mortality , Female , Humans , Incidence , Italy/epidemiology , Male
19.
Epidemiol Prev ; 19(63): 150-60, 1995 Jun.
Article in Italian | MEDLINE | ID: mdl-7641857

ABSTRACT

The Italian Morality Atlas at municipality level, sponsored by the Health Ministry and realized by the Emilia-Romagna region in collaboration with the Institute of Medical Statistics of Milano, is aimed at: 1) supporting and stimulating the local production of mortality maps and the use of geographical data; 2) providing a working and research tool to local health planners; 3) setting a routine procedure for the detection of spatial clusters. This procedure is organized in several steps: the definition of the spatial domain and of the spatial distance metrics; the choice of the effect indicator and the standard population; the estimate of the density risk surface via kernel methods; the identification of "local maxima"; the analysis of local maxima for cluster detection; the description of the identified clusters. The paper investigates the meaning and the characteristics of spatial clusters, describes the procedure for their identification and discusses the opportunity to use an automated approach for map reading.


Subject(s)
Cervical Atlas , Health Status , Public Health , Cluster Analysis , Gastrointestinal Neoplasms/epidemiology , Humans , Incidence , Italy/epidemiology
20.
Ultrasound Obstet Gynecol ; 5(1): 9-14, 1995 Jan.
Article in English | MEDLINE | ID: mdl-7850598

ABSTRACT

The value of the measurement of nuchal translucency thickness for predicting fetal Down's syndrome and other aneuploidies was prospectively evaluated at 8-15 weeks of gestation in 1819 consecutive pregnancies scheduled for karyotyping by chorionic villus sampling. In 43 cases, a chromosomal unbalanced aberration was found. Two teams of ultrasonologists who examined patients attending either National Health Service (Series 1) or private practice clinics (Series 2) were involved in the study. The same type of ultrasound machine and standardized approach were used in both study groups. In those cases in which the maximum subcutaneous thickness of the translucency was 3 mm or greater, the incidence of chromosomal aberration was 18.6% compared to 1.7% in the cases in which this was below 3 mm. The sensitivity, specificity and relative risk for all aneuploidies were 30%, 96% and 10.83, respectively, and no difference was found between trisomy 21 and other types of aneuploidy. The sensitivity and specificity and relative risk were significantly higher at 9-10 weeks than between 11 and 15 weeks. The results were concordant in the two series; however, the overall values for sensitivity (20% vs. 39%), specificity (94% vs. 98%) and relative risk (4.13 vs. 24.20) were clearly higher in the group of private patients. The results obtained confirm the potential application of the measurement of nuchal translucency thickness for fetal aneuploidy screening before the end of the first trimester and suggest that a multiplicity of individual, structural and organizational factors may interact and play a crucial role in determining the actual efficiency of ultrasound screening programs.


Subject(s)
Chorionic Villi Sampling , Down Syndrome/diagnosis , Fetal Diseases/diagnosis , Ultrasonography, Prenatal , Adult , Aneuploidy , Chromosome Aberrations/diagnosis , Chromosome Aberrations/genetics , Chromosome Disorders , Cohort Studies , Down Syndrome/genetics , Female , Fetal Diseases/genetics , Humans , Karyotyping , Mass Screening , Maternal Age , Middle Aged , Neck/diagnostic imaging , Pilot Projects , Pregnancy , Pregnancy Trimester, First , Prospective Studies , Risk Factors , Sensitivity and Specificity
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