ABSTRACT
Plasma levels of dehydroepiandrosterone sulfate (DHEA-S), testosterone, dihydrotestosterone (DHT) androstenedione, sex hormone-binding globulin (SHBG), lipoproteins, apolipoproteins and high density lipoprotein (HDL) subfraction were measured in 32 men aged 26-40 years after myocardial infarction (MI) suffered at least 3-4 months prior to the study, who were normocholesterolemic and had angiographically demonstrated coronary occlusion. The control group consisted of 76 healthy men aged 25-40 years. Blood samples were obtained in the morning from fasting subjects. A significant decrease in plasma DHEA-S and DHT levels were found in MI patients. Also, a significant decrease in HDL-cholesterol, HDL2-cholesterol (HDL2-C) and apolipoprotein A-I, an increase in apolipoprotein B and LDL-cholesterol (LDL-C) levels were observed in those patients as compared with healthy men. However, there were no differences in testosterone, androstenedione and SHBG concentrations between the groups. Significant correlations between testosterone and HDL2-C (r = 0.46, P less than 0.01), as well as between DHEA-S and HDL3-C (r = 0.39, P less than 0.05) levels in MI patients were observed. These results suggest that decreased levels of plasma DHEA-S and DHT may promote the development of coronary atherosclerosis in men.
Subject(s)
Androstenedione/blood , Dehydroepiandrosterone/analogs & derivatives , Dihydrotestosterone/blood , Myocardial Infarction/blood , Adult , Apolipoproteins/analysis , Dehydroepiandrosterone/blood , Dehydroepiandrosterone Sulfate , Humans , Lipoproteins/analysis , Male , Sex Hormone-Binding Globulin/analysis , Testosterone/blood , Triglycerides/analysisABSTRACT
The paper deals with the application of carotid resonance electrosphygmography (CRESG) to primary arterial hypertension (PAH) and primary hyperlipoproteinaemia (PHLP). On a group of 145 patients with PAH (and a control group of 63 healthy persons) aged 20--50 years and on a group of 30 patients with PHLP (plus a control group of 43 healthy persons) aged 30--60 years, the records were taken bilaterally. In both groups significant quantitative differences in the sphygmograms were found which are indicative for reduced distensibility and indirectly for the degeneration of the arterial wall. It is concluded that an effective follow-up of the progress of degenerative changes can be made by CRESG.
Subject(s)
Arteries/physiopathology , Blood Pressure , Electrodiagnosis , Hyperlipoproteinemias/physiopathology , Hypertension/physiopathology , Pulse , Adult , Carotid Arteries/physiology , Female , Humans , Hyperlipoproteinemias/complications , Hypertension/complications , Male , Middle Aged , Vascular Diseases/etiology , Vascular Diseases/physiopathologySubject(s)
Carbohydrate Metabolism , Glucagon/pharmacology , Hyperlipidemias/metabolism , Lipid Metabolism , Female , Humans , Lipoproteins/blood , MaleABSTRACT
In 106 patients with essential hypertension and different plasma renin activity several hormonal and metabolic factors were studied: urinary excretion of catecholamines, blood levels of cholesterol and triglycerides, levels of glycaemia and insulinaemia after glucose load and plasma fibrinolytic activity. The plasma renin activity in 46.2 percent of patients was normal, whereas in 25.5 percent it was low, and in 28.3 percent it was high. In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low. Significantly lower triglyceride levels were found in patients with low plasma renin activity in comparison with those with high and normal plasma renin activity. There was also a statistically significant difference in the euglobulin lysis time which was shorter in patients with low and longest in patients with normal plasma renin activity. The results of the study show that patients with different plasma renin activity may also differ in some hormonal and metabolic values.
