ABSTRACT
After the experimental application of sulphur mustard contained in Psoriazin produced by Medexport, the kidney of white rats is examined by means of histologic and histochemical methods. It was noted that the prolonged application of Psoriazin caused changes in the convoluted tubules.
Subject(s)
Kidney Tubules/drug effects , Kidney/drug effects , Mustard Compounds/toxicity , Mustard Gas/toxicity , Administration, Topical , Animals , Male , Mustard Gas/administration & dosage , Rats , Rats, Inbred StrainsABSTRACT
Fetal liver was examined in rats, whose mothers during pregnancy received Turinal (firm: Chemical Works of Gedeon Richter LTD Budapest, Hungary) in a dosage of 0.5 mg/kg BW in the experimental group I and 1 mg/kg BW in the experimental group II. Reaction to the activity of succinate dehydrogenase, lactic dehydrogenase, acid phosphatase, glucose-6-phosphatase, PAS-reaction (Periodic acid Schiff reaction) and hematoxylin-eosin staining were carried out. Changes in the activity of examined enzymes and PAS-reaction in fetal liver depending on dosage were observed. These changes testify to a large influence of administered hormone on metabolism of developing fetal liver.
Subject(s)
Allylestrenol/pharmacology , Fetus/drug effects , Liver/drug effects , Liver/embryology , Animals , Female , Liver/enzymology , Maternal-Fetal Exchange , Pregnancy , Rats , Rats, WistarSubject(s)
Duodenum/enzymology , Intestinal Mucosa/enzymology , Mefenamic Acid/pharmacology , Acid Phosphatase/metabolism , Adenosine Triphosphatases/antagonists & inhibitors , Adenosine Triphosphatases/metabolism , Alkaline Phosphatase/antagonists & inhibitors , Alkaline Phosphatase/metabolism , Animals , Enzyme Activation/drug effects , Periodic Acid-Schiff Reaction , Rats , Succinate Dehydrogenase/antagonists & inhibitors , Succinate Dehydrogenase/metabolismABSTRACT
The effect of Biseptol on the mucous membrane of the stomach of an unoperated white rat was analysed and also the effect after liver lobectomy or unilateral nephrectomy. There were performed histochemical reactions to mucopolysaccharides and nucleic acids as well as staining with hematoxyline ond eosine. After administration of Biseptol in a dose of 270 mg/kg b.w. for 7 consecutive d, increased secretion of mucous and inflammation in gastric mucous membrane was observed. No intensification of these symptoms was found after administration of Biseptol to operated animals. It may be supposed that hepatectomy and nephrectomy are not counterindications for the use of Biseptol.