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1.
Med Econ ; 73(15): 173-4, 177-9, 1996 Aug 12.
Article in English | MEDLINE | ID: mdl-10159452
2.
Ann Intern Med ; 116(12 Pt 1): 1035; author reply 1036-7, 1992 Jun 15.
Article in English | MEDLINE | ID: mdl-1586100
3.
Am J Cardiol ; 61(10): 807-11, 1988 Apr 01.
Article in English | MEDLINE | ID: mdl-2895577

ABSTRACT

A randomized double-blind multicenter study compared a new oral beta 1-adrenergic antagonist, betaxolol 10 to 40 mg (n = 71), with atenolol 25 to 100 mg (n = 75). Each drug was administered once daily for 24 weeks in patients with mild to moderate hypertension. Blood pressure (BP) measurements were taken 24 hours after dosing. Each drug produced significant (p less than 0.01) reductions in mean supine diastolic BP. The mean decrease in supine diastolic BP with betaxolol was significantly greater at weeks 4, 6, 10 and 12 (p less than 0.05). Throughout the remainder of the trial (weeks 14 to 24), no significant differences in BP reduction were noted between treatment groups. Normotension (supine diastolic BP less than or equal to 90 mm Hg) was achieved in 72% of those given betaxolol compared with 52% of those given atenolol (p less than 0.05). The most common side effects noted were bradycardia, fatigue and headache. The incidence of these and of central nervous system side effects was similar between the betaxolol and atenolol groups. Both agents were well tolerated. At recommended doses, betaxolol once daily may be more effective than atenolol once daily in patients with mild to moderate hypertension.


Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Atenolol/therapeutic use , Hypertension/drug therapy , Propanolamines/therapeutic use , Adrenergic beta-Antagonists/adverse effects , Atenolol/adverse effects , Betaxolol , Blood Pressure/drug effects , Bradycardia/chemically induced , Clinical Trials as Topic , Double-Blind Method , Fatigue/chemically induced , Headache/chemically induced , Humans , Propanolamines/adverse effects , Random Allocation , Time Factors
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