1.
J Med Chem
; 50(24): 5882-5, 2007 Nov 29.
Article
in English
| MEDLINE
| ID: mdl-17963373
ABSTRACT
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.
Subject(s)
Adamantane/analogs & derivatives , Adamantane/chemical synthesis , Benzamides/chemical synthesis , Interleukin-1beta/antagonists & inhibitors , Purinergic P2 Receptor Antagonists , Adamantane/pharmacology , Animals , Benzamides/pharmacology , Blood Proteins/metabolism , Crystallography, X-Ray , Humans , In Vitro Techniques , Molecular Conformation , Monocytes/metabolism , Protein Binding , Rats , Receptors, Purinergic P2X7 , Structure-Activity Relationship
2.
Chem Commun (Camb)
; (21): 2656-7, 2003 Nov 07.
Article
in English
| MEDLINE
| ID: mdl-14649796
ABSTRACT
Amidocyclopropanes are readily prepared by reaction of N-diethoxymethyl amides with alkenes in the presence of zinc amagalm, zinc chloride and chlorotrimethylsilane.
