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1.
J Am Vet Med Assoc ; 262(1): 1-5, 2024 Jan 01.
Article in English | MEDLINE | ID: mdl-38103385

ABSTRACT

OBJECTIVE: To investigate pseudohyperkalemia occurring in horses experiencing rhabdomyolysis when serum chemistry profiles are run on an VetScan VS2 analyzer (Abaxis). ANIMALS: 18 horses with rhabdomyolysis (creatine kinase [CK] > 1,000 U/L). METHODS: In 3 horses with serum CK activities > 5,800 U/L and persistent serum potassium concentrations of > 8.5 mmol/L (VetScan VS2), potassium concentrations were reevaluated with either i-STAT Alinity Base Station (Abbott), Catalyst (Idexx), or Cobas c501 (Roche) ion-specific analyzers. Paired serum samples from 15 additional horses (median serum CK activity, 7,601 U/L; range, 1,134 to 192,447 U/L) were analyzed on both VetScan VS2 and Cobas c501 machines. Serum potassium concentrations were compared between the VetScan VS2 and ion-specific analyzers by Bland-Altman and Wilcoxon ranked tests and correlated to log10 CK activity via Pearson correlation. RESULTS: Serum potassium concentrations were significantly higher on the VetScan VS2 (6.7 ± 1.6 mmol/L) versus the ion-specific analyzers (4.0 ± 1.1 mmol/L; P < .0001), with high bias shown in Bland-Altman analysis (43.1 ± 27.9). Potassium concentrations positively correlated with log10 CK activity with the VetScan VS2 (R2 = 0.51; P = .003) but not the Cobas (R2 = 0.09; P = .3) analyzer. CLINICAL RELEVANCE: An alternate analyzer to the VetScan VS2 should be used to evaluate serum potassium concentrations in horses with rhabdomyolysis because the VetScan VS2 methodology uses lactate dehydrogenase, which increases in serum with rhabdomyolysis and falsely elevates potassium concentrations.


Subject(s)
Horse Diseases , Rhabdomyolysis , Animals , Horses , Potassium , Rhabdomyolysis/veterinary
2.
Can Vet J ; 63(6): 589-592, 2022 06.
Article in English | MEDLINE | ID: mdl-35656526

ABSTRACT

A 12-year-old neutered male American Staffordshire terrier dog was referred to the Atlantic Veterinary College, Prince Edward Island, Canada, for suspected immune-mediated hemolytic anemia. Babesiosis (Babesia vulpes) was confirmed using polymerase chain reaction testing. The dog was successfully treated with a 10-day protocol of atovaquone/proguanil (TEVA Pharmaceutical Industries, Toronto, Ontario), 13.5 mg/kg BW, PO, q8h and azithromycin (Pharmascience, Montreal, Quebec), 10 mg/kg BW, PO, q24h. To the authors' knowledge, this report is the first documented case of babesiosis caused by Babesia vulpes in a dog from Canada.


Babesia vulpes chez un chien de l'Île-du-Prince-Édouard, Canada. Un chien American Staffordshire terrier mâle castré de 12 ans a été référé au Atlantic Veterinary College, Île-du-Prince-Édouard, Canada, pour suspicion d'anémie hémolytique à médiation immunitaire. La babésiose (Babesia vulpes) a été confirmée à l'aide d'un test d'amplification en chaîne par la polymérase. Le chien a été traité avec succès avec un protocole de 10 jours d'atovaquone/proguanil (TEVA Pharmaceutical Industries, Toronto, Ontario), 13,5 mg/kg BW, PO, q8h et azithromycine (Pharmascience, Montréal, Québec), 10 mg/kg BW, PO, q24h. À la connaissance des auteurs, ce rapport est le premier cas documenté de babésiose causée par Babesia vulpes chez un chien du Canada.(Traduit par Dr Serge Messier).


Subject(s)
Babesia , Babesiosis , Dog Diseases , Animals , Babesiosis/diagnosis , Babesiosis/drug therapy , Dog Diseases/diagnosis , Dog Diseases/drug therapy , Dogs , Humans , Male , Ontario , Polymerase Chain Reaction/veterinary , Prince Edward Island/epidemiology
3.
J Am Vet Med Assoc ; 259(S2): 1-4, 2022 05 15.
Article in English | MEDLINE | ID: mdl-35560121

ABSTRACT

In collaboration with the American College of Veterinary Pathologists.


Subject(s)
Pathology, Veterinary , Veterinarians , Animals , Humans , United States
5.
Can Vet J ; 53(4): 383-6, 2012 Apr.
Article in English | MEDLINE | ID: mdl-23024383

ABSTRACT

A 16-month-old spayed female mixed breed dog was presented with a 1-week history of anorexia, lethargy, diarrhea, vomiting, and difficulty rising. Hematologic evaluation indicated a marked macrocytic hypo-chromic, markedly regenerative anemia. A metallic foreign object in the gastrointestinal tract was identified on abdominal radiographs. Serum zinc concentration was markedly increased.


Subject(s)
Anemia, Hemolytic/veterinary , Dog Diseases/chemically induced , Foreign Bodies/veterinary , Zinc/poisoning , Anemia, Hemolytic/blood , Anemia, Hemolytic/chemically induced , Animals , Dog Diseases/blood , Dogs , Female , Play and Playthings , Zinc/blood
6.
Can Vet J ; 52(5): 537-40, 2011 May.
Article in English | MEDLINE | ID: mdl-22043078

ABSTRACT

A 16-year-old Paint stallion was presented with intermittent fever, inappetance, lethargy, icterus, distal limb edema, and submandibular lymphadenopathy. The horse was native to Nova Scotia and had never left that province. Morulae were detected in granulocytes. Ananaplasma phagocytophilum infection was confirmed by serology and polymerase chain reaction (PCR). The horse responded to treatment with oxytetracycline.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Ehrlichiosis/veterinary , Horse Diseases/diagnosis , Oxytetracycline/therapeutic use , Anaplasma phagocytophilum/isolation & purification , Animals , Ehrlichiosis/diagnosis , Ehrlichiosis/drug therapy , Horse Diseases/drug therapy , Horses , Male , Nova Scotia , Treatment Outcome
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