ABSTRACT
How cholesterol influences the microcirculation on aging subjects is not well known. This study evaluated moderate hypercholesterolemia effects in, treated or not, lean elderly women on brachial artery reactivity and microcirculatory function using venous occlusion plethysmography (VOP) and nailfold videocapillaroscopy (NVC). Patients (mean age 73 years) were divided into healthy elderly (HE, n=15), treated dyslipidemia with statins during at least 6 months (TDL, n=9) and dyslipidemia (DL, n=9, cholesterol, 257±11 and LDL-cholesterol, 157±24 mg/dl). Young, mean age 23 years, women (YC, n=24), served as controls. Laboratory and anthropometrical analysis, VOP peak forearm blood flow (FBF) during the reactive hyperemia response/baseline FBF (%HYPER) and peak FBF after 0.4 mg sublingual nitroglycerin/baseline FBF (%NITRO) were assessed. NVC capillary density and diameters, maximum red blood cell velocity (RBCV(max)) during reactive hyperemia/baseline RBCV and time to reach RBCV(max) were evaluated. Correlations between %HYPER, %NITRO and plasma cholesterol fractions were performed. Total and LDL-cholesterol were increased only in DL group. Capillary diameters were larger in elderly groups than YC. RBCV(max)/baseline RBCV was reduced in the DL group compared to HE, TDL and YC. %HYPER was lower in DL and normalized in TDL group. YC %HYPER was double of HE. %NITRO decreased from (HE=YC) to TDL and DL groups. There was a significant inverse correlation between LDL-cholesterol, non-HDL-cholesterol and %HYPER/% Nitro. In conclusion, moderate hypercholesterolemia reversibly impaired the vasodilatatory response in the microcirculation but the endothelial-independent vasodilator response to nitroglycerine remained irreversibly lower in healthy aged women.
Subject(s)
Dyslipidemias/blood , Hypercholesterolemia/physiopathology , Microcirculation , Adult , Age Factors , Aged , Anthropometry , Blood Flow Velocity , Cholesterol/blood , Cholesterol/metabolism , Cholesterol, LDL/metabolism , Erythrocytes/cytology , Female , Humans , Hypercholesterolemia/blood , Hyperemia , Microscopic Angioscopy/methods , Microscopy, Video/methods , Nitroglycerin/metabolism , Plethysmography/methods , Risk Factors , Time Factors , VasodilationABSTRACT
OBJECTIVES: Compare the administering technique, local tolerance and clinical and laboratory response to hormone replacement therapy with 17-beta estradiol in gel and patch in Brazil, a tropical country. METHODS: We carried out a transversal study by means of an outpatient interview completed by 66 menopausal women, 42 using gel, and 24 utilizing patches. We focused on the main problems with the two forms of replacement, in summer and at other times during the year. RESULTS: The average daily dose of 17-beta estradiol administered was 150 microg in the GEL GROUP and 50 microg in the PATCH GROUP. Reports of itching (33.3%) and local skin reactions (54. 2%) occurred exclusively in the PATCH GROUP. The patches came detached in 54.2% of the patients. These problems were more frequent in the summer. There was no significant difference in the regularity of administering (P=0.38) nor in the levels of FSH (P=0.16) and LH (P=0.33) between the two groups. Problems with the application technique (P=0.002) and the blood levels of estradiol (P=0.0002) were greater in the GEL GROUP, while symptoms of hypoestrogenism predominated in the PATCH GROUP (P=0.002). CONCLUSIONS: We concluded that, in our environment, the use of 17-beta estradiol in gel presented fewer local skin reactions, was more effective in alleviating the symptoms of hypoestrogenism and had better acceptance in hormone replacement therapy for menopausal women, as compared with the 17-beta estradiol patch.