ABSTRACT
Urocortin (Ucn)-2 has shown promising therapeutic effects on heart failure (HF). However, there are still significant knowledge gaps regarding the role and modulation of the endogenous Ucn-2 axis in the cardiovascular system and, specifically, in acute HF. We evaluated Ucn-2 levels in admission serum samples of 80 acute HF patients and assessed their association with clinical, analytical and echocardiographic parameters. Median age was 76.5 years, and 37 patients (46%) were male. Median serum Ucn-2 was 2.3ng/mL. Ucn-2 levels were positively associated with peripheral edemas (Pâ¯=â¯0.022), hepatomegaly (Pâ¯=â¯0.007) and sodium retention score (ρâ¯=â¯0.37, Pâ¯=â¯0.001) and inversely correlated with inferior vena cava collapse at inspiration (ρâ¯=â¯-0.37, Pâ¯=â¯0.001). Additionally, patients with higher Ucn-2 levels had a higher prevalence of right atrial dilation (Pâ¯=â¯0.027), right ventricle dilation (Pâ¯=â¯0.008), and higher systolic pulmonary artery pressure (ρâ¯=â¯0.34, Pâ¯=â¯0.002). Regarding analytical parameters, Ucn-2 correlated positively with log BNP (râ¯=â¯0.22, Pâ¯=â¯0.055) and inversely with uric acid (râ¯=â¯0.24, Pâ¯=â¯0.029) and total (râ¯=â¯-0.30, Pâ¯=â¯0.007) and low-density lipoprotein cholesterol (râ¯=â¯-0.23, Pâ¯=â¯0.038). No associations were found between Ucn-2 and age, sex or left heart structure or function. In conclusion, Circulating Ucn-2 was associated with clinical and echocardiographic markers of volume overload and pulmonary hypertension in acute HF patients.