ABSTRACT
One characteristic of chronic obstructive bronchopneumopathies, especially bronchial asthma, is the slowing down of respiratory flow. Spirographic studies are therefore valued highly among specialists in respiratory pathology. All of those working in this field of physiopathology, however, agree that broncodynamic provocation tests are not fully specific for bronchial asthma. One important problem is the difficulty in determining the quantity of product inhaled by the patient, making the test even less precise. With our method, based on the broncotest developed by Piglowski, we are able to determine the quantity of inhaled material with a fairly high degree of accuracy. It thus represents a quantitative study and is much more specific. One hundred patients with bronchial asthma, whose ages ranged from 14 to 60 years, were selected for this study. We found that 100% of them (except for one 16-year-old patient whose case has been commented on) were positive for the acetylcholine aerosol test and for beta-2adrenergics (phenotherol). These results enabled us to establish diagnostic patterns for the severity of bronchial hyperactivity in relation to the number of micrograms needed to provoke a 20% variation in the VEMS. We consider it very important to determine the threshold does of acetylcholine, since it may serve in both diagnosis and prognosis. We believe that this method may represent a new direction in pharmacodynamic examination of asthma patients.
