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1.
Int J Speech Lang Pathol ; 25(1): 9-14, 2023 02.
Article in English | MEDLINE | ID: mdl-36476000

ABSTRACT

PURPOSE: This invited commentary addresses the importance of the senses in human communication, outlines advances achieved with cochlear implants, and new research directions to improve neural prostheses. RESULT: In severely deaf people, cochlear implants restore speech understanding and enable children to achieve spoken language. Research in neural prostheses is advancing the restoration of hearing, vision, tactile senses, movement and the management of epilepsy. Bio-inspired stimulation strategies incorporating temporal and spatial characteristics of neural responses may deliver improved speech, vision and tactile perception using prostheses. To achieve stable long-term stimulation, chronic inflammation at the brain-electrode interface may be reduced using ROCK/Rho signalling pathway inhibitors and materials with brain-mimicking properties. CONCLUSION: This commentary paper addresses two Sustainable Development Goals: industry, innovation and infrastructure (SDG 9) and good health and well-being (SDG 3).


Subject(s)
Cochlear Implantation , Cochlear Implants , Child , Humans , Sustainable Development , Speech
2.
Cochlear Implants Int ; 17(3): 129-31, 2016 May.
Article in English | MEDLINE | ID: mdl-27078517

ABSTRACT

OBJECTIVES: The aim of this study was to analyse the tissue surrounding the University of Melbourne's (UOMs) multi-channel cochlear implant electrode array and cochlear limited replacements, after long-term implantations. In particular, it aimed to identify the particulate material in the fibrous tissue capsule of the arrays implanted in 1978, 1983, and 1998, by using the Australian Synchrotron for X-ray fluorescence microscopy (XFM) to reveal the characteristic spectrum of metal, in particular platinum. This also helped to determine its format and chemical state. Tissue was retrieved following the recipient's death in 2007. METHODS: Tissue was fixed and sections taken across the UOM and Cochlear Corporation (CI-22 and CI-24) electrode tracks. These were stained with Masson's trichrome. The Australian Synchrotron enabled XFM to accurately identify platinum from its characteristic fluorescence spectrum. RESULTS: There was a fibrous tissue capsule (about 100-µm thick) and small regions of calcification around the UOM and CI-22 arrays, but a thinner capsule (40-60-µm thick) around CI-24, and a greater degree of calcification. Dark particulate matter was observed within macrophages and especially in fibrous tissue in proximity to the UOM and CI-22 arrays. This was identified as platinum using X-ray fluorescence. There was also diffusion of platinum into the tissue surrounding the UOM and CI-22 electrodes and fine particles had penetrated the spiral ligament. DISCUSSION: The larger particulate matter in the tissue around the UOM and CI-22 arrays suggested that it had flaked off in the manufacturing of the UOM electrodes. The more diffuse spread of platinum in the tissue around the UOM and CI-22 electrodes was likely due to electrolysis, probably from charge imbalance with the bipolar pulses from the UOM implant. This did not occur with the Cochlear CI-24 device. Furthermore, the widespread fine particles of platinum could have also been due to corrosion, especially from the UOM electrodes.


Subject(s)
Cochlear Implants/adverse effects , Electrodes, Implanted/adverse effects , Microscopy, Fluorescence/methods , Particulate Matter/analysis , Platinum/analysis , Australia , Autopsy , Calcinosis/diagnostic imaging , Calcinosis/etiology , Calcinosis/pathology , Cochlea/chemistry , Cochlea/diagnostic imaging , Cochlea/pathology , Humans , Macrophages/chemistry , Macrophages/pathology , Postoperative Complications/diagnostic imaging , Postoperative Complications/etiology , Postoperative Complications/pathology , Time , X-Rays
4.
Analyst ; 140(9): 3164-74, 2015 May 07.
Article in English | MEDLINE | ID: mdl-25773879

ABSTRACT

Electrode impedance is used to assess the thermal noise and signal-to-noise ratio for brain-machine interfaces. An intermediate frequency of 1 kHz is typically measured, although other frequencies may be better predictors of device performance. PEDOT-PSS, PEDOT-DBSA and PEDOT-pTs conducting polymer modified electrodes have reduced impedance at 1 kHz compared to bare metal electrodes, but have no correlation with the effective electrode area. Analytical solutions to impedance indicate that all low-intermediate frequencies can be used to compare the electrode area at a series RC circuit, typical of an ideal metal electrode in a conductive solution. More complex equivalent circuits can be used for the modified electrodes, with a simplified Randles circuit applied to PEDOT-PSS and PEDOT-pTs and a Randles circuit including a Warburg impedance element for PEDOT-DBSA at 0 V. The impedance and phase angle at low frequencies using both equivalent circuit models is dependent on the electrode area. Low frequencies may therefore provide better predictions of the thermal noise and signal-to-noise ratio at modified electrodes. The coefficient of variation of the PEDOT-pTs impedance at low frequencies was lower than the other conducting polymers, consistent with linear and steady-state electroactive area measurements. There are poor correlations between the impedance and the charge density as they are not ideal metal electrodes.


Subject(s)
Brain-Computer Interfaces , Dextrans/chemistry , Polystyrenes/chemistry , Sulfonamides/chemistry , Thiophenes/chemistry , Dielectric Spectroscopy , Electric Impedance , Electrodes , Humans
5.
Anal Chem ; 87(1): 738-46, 2015 Jan 06.
Article in English | MEDLINE | ID: mdl-25495574

ABSTRACT

Neural stimulation is used in the cochlear implant, bionic eye, and deep brain stimulation, which involves implantation of an array of electrodes into a patient's brain. The current passed through the electrodes is used to provide sensory queues or reduce symptoms associated with movement disorders and increasingly for psychological and pain therapies. Poor control of electrode properties can lead to suboptimal performance; however, there are currently no standard methods to assess them, including the electrode area and charge density. Here we demonstrate optical and electrochemical methods for measuring these electrode properties and show the charge density is dependent on electrode geometry. This technique highlights that materials can have widely different charge densities but also large variation in performance. Measurement of charge density from an electroactive area may result in new materials and electrode geometries that improve patient outcomes and reduce side effects.


Subject(s)
Brain/physiology , Electric Stimulation , Electrochemical Techniques/methods , Electrodes , Polymers/chemistry , Humans
6.
Hear Res ; 322: 4-13, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25159273

ABSTRACT

This multi-disciplinary research showed sound could be coded by electrical stimulation of the cochlea and peripheral auditory nervous system. But the temporal coding of frequency as seen in the experimental animal, was inadequate for the important speech frequencies. The data indicated the limitation was due in particular to deterministic firing of neurons and failure to reproduce the normal fine temporo-spatial pattern of neural responses seen with sound. However, the data also showed the need for the place coding of frequency, and this meant multi-electrodes inserted into the cochlea. Nevertheless, before this was evaluated on people we undertook biological safety studies to determine the effects of surgical trauma and electrical stimuli, and how to prevent infection. Then our research demonstrated place of stimulation had timbre and was perceived as vowels. This led to our discovery in 1978 of the formant-extraction speech code that first enabled severely-profoundly deaf people to understand running speech. This result in people who had hearing before becoming severely deaf was an outcome not previously considered possible. In 1985 it was the first multi-channel implant to be approved by the US Food and Drug Administration (FDA). It was also the fore runner of our advanced formant and fixed filter strategies When these codes were used from 1985 for those born deaf or deafened early in life we discovered there was a critical period when brain plasticity would allow speech perception and language to be developed near- normally, and this required in particular the acquisition of place coding. In 1990 this led to the first cochlear implant to be approved by the FDA for use in children. Finally, we achieved binaural hearing in 1989 with bilateral cochlear implants, followed by bimodal speech processing in 1990 with a hearing aid in one ear and implant in the other. The above research has been developed industrially, with for example 250,000 people worldwide receiving the Cochlear device in 2013, and as of December 2012 the NIH estimated that approximately 324,200 people worldwide had received this and other implants (NIH Publication No. 11-4798). This article is part of a Special Issue entitled .


Subject(s)
Cochlear Implantation/instrumentation , Cochlear Implants , Interdisciplinary Communication , Persons With Hearing Impairments/rehabilitation , Speech Perception , Acoustic Stimulation , Animals , Comprehension , Cooperative Behavior , Electric Stimulation , Humans , Persons With Hearing Impairments/psychology , Prosthesis Design , Signal Processing, Computer-Assisted , Speech Intelligibility
7.
Cochlear Implants Int ; 15 Suppl 2: S1-15, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24915284

ABSTRACT

OBJECTIVE: To analyse the temporal bones and implant of the first University of Melbourne's (UOM) patient (MC-1) to receive the multi-channel cochlear prosthesis. METHODS: The left cochlea was implanted with the prototype multi-channel cochlear prosthesis on 1 August 1978, and the Cochlear versions CI-22 and CI-24 on 22 June 1983 and 10 November 1998, respectively. MC-1 died in 2007. RESULTS: Plain X-rays of the temporal bones showed that after the CI-22 had been explanted seven electrode bands remained in situ. Micro-CT scans also revealed a partially united fracture transecting the left implanted and right control cochleae. Histology indicated a total loss of the organ of Corti on both sides, and a tear of the left basilar membrane. In addition, there was a dense fibrous capsule with heterotopic bone surrounding one proximal band of the CI-22 array that restricted its removal. This pathology was associated with dark particulate material within macrophages, probably due to the release of platinum from the electrode bands. Scanning electron microscopy (SEM) showed possible corrosion of platinum and surface roughening. Three-dimensional reconstruction of the cochlear histology demonstrated the position of the electrode tracts (C1-22 and CI-24) in relation to the spiral ganglion, which showed 85-90% loss of ganglion cells. DISCUSSION AND CONCLUSIONS: This study confirms our first histopathological findings that our first free-fitting banded electrode array produced moderate trauma to the cochlea when inserted around the scala tympani of the basal turn. The difficulty in extraction was most likely due to one band being surrounded by an unusually large amount of fibrous tissue and bone, with an electrode band caught due to surface irregularities. Some surface corrosion and a small degree of platinum deposition in the tissue may also help explain the outcome for this long-term cochlear implantation.


Subject(s)
Cochlea/pathology , Cochlear Implantation , Cochlear Implants , Deafness/pathology , Deafness/therapy , Temporal Bone/pathology , Aged , Australia , Cochlea/surgery , Deafness/etiology , Device Removal , Humans , Male , Middle Aged , Prosthesis Design
8.
Nat Med ; 19(10): 1236-9, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24100994
10.
Biomater Sci ; 1(9): 983-995, 2013 Sep 30.
Article in English | MEDLINE | ID: mdl-32481966

ABSTRACT

Polythiophenes are attractive candidate polymers for use in synthetic cell scaffolds as they are amenable to modification of functional groups as a means by which to increase biocompatibility. In the current study we analysed the physical properties and response of primary myoblasts to three thiophene polymers synthesized from either a basic bithiophene monomer or from one of two different thiophene monomers with alkoxy functional groups. In addition, the effect of the dopants pTS- and ClO4 - was investigated. In general, it was found that pTS- doped polymers were significantly smoother and tended to be more hydrophilic than their ClO4 - doped counterparts, demonstrating that the choice of dopant significantly affects the polythiophene physical properties. These properties had a significant effect on the response of primary myoblasts to the polymer surfaces; LDH activity measured from cells harvested at 24 and 48 h post-seeding revealed significant differences between numbers of cells attaching to the different thiophene polymers, whilst all of the polymers equally supported cell doubling over the 48 h period. Differences in morphology were also observed, with reduced cell spreading observed on polymers with alkoxy groups. In addition, significant differences were seen in the polymers' ability to support myoblast fusion. In general pTS- doped polymers were better able to support fusion than their ClO4 - doped counterparts. These studies demonstrate that modification of thiophene polymers can be used to promote specific cellular response (e.g. proliferation over differentiation) without the use of biological agents.

12.
Small ; 7(8): 1035-42, 2011 Apr 18.
Article in English | MEDLINE | ID: mdl-21374804

ABSTRACT

In vivo host responses to an electrode-like array of aligned carbon nanotubes (ACNTs) embedded within a biopolymer sheet are reported. This biocompatibility study assesses the suitability of immobilized carbon nanotubes for bionic devices. Inflammatory responses and foreign-body histiocytic reactions are not substantially elevated when compared to negative controls following 12 weeks implantation. A fibrous capsule isolates the implanted ACNTs from the surrounding muscle tissue. Filamentous nanotube fragments are engulfed by macrophages, and globular debris is incorporated into the fibrous capsule with no further reaction. Scattered leukocytes are observed, adherent to the ACNT surface. These data indicate that there is a minimal local foreign-body response to immobilized ACNTs, that detached fragments are phagocytosed into an inert material, and that ACNTs do not attract high levels of surface fouling. Collectively, these results suggest that immobilized nanotube structures should be considered for further investigation as bionic components.


Subject(s)
Biocompatible Materials/chemistry , Materials Testing/methods , Nanotubes, Carbon/chemistry , Animals , Biofouling , Foreign-Body Reaction/pathology , Guinea Pigs , Implants, Experimental , Male , Phagocytosis , Styrenes/chemistry
13.
Otolaryngol Head Neck Surg ; 143(5 Suppl 3): S15-23, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20970686

ABSTRACT

OBJECTIVE: This review describes the current concept of pneumococcal meningitis in cochlear implant recipients based on recent laboratory studies. It examines possible routes of Streptococcus pneumoniae infection to the meninges in cochlear implant recipients. It also provides insights into fundamental questions concerning the pathophysiology of pneumococcal meningitis in implant recipients. DATA SOURCES: Medline/PubMed database; English articles after 1960. Search terms: cochlear implants, meningitis, pneumococcus, streptococcus pneumonia. REVIEW METHODS: Narrative review. All articles relating to post-implant meningitis without any restriction in study designs were assessed and information extracted. RESULTS: The incidence of pneumococcal meningitis in cochlear implant recipients is greater than that of an age-matched cohort in the general population. Based on the current clinical literature, it is difficult to determine whether cochlear implantation per se increases the risk of meningitis in subjects with no existing risk factors for acquiring the disease. As this question cannot be answered in humans, the study of implant-related infection must involve the use of laboratory animals in order for the research findings to be applicable to a clinical situation. The laboratory research demonstrated the routes of infection and the effects of the cochlear implant in lowering the threshold for pneumococcal meningitis. CONCLUSION: The laboratory data complement the existing clinical data on the risk of pneumococcal meningitis post-cochlear implantation.


Subject(s)
Cochlear Implantation/adverse effects , Cochlear Implants/adverse effects , Ear, Inner/injuries , Meningitis, Pneumococcal/etiology , Meningitis, Pneumococcal/physiopathology , Prosthesis-Related Infections/etiology , Prosthesis-Related Infections/physiopathology , Animals , Biofilms , Ear, Inner/pathology , Humans , Meningitis, Pneumococcal/epidemiology , Meningitis, Pneumococcal/microbiology , Prosthesis-Related Infections/epidemiology , Prosthesis-Related Infections/microbiology , Risk Factors , Streptococcus pneumoniae
14.
Otolaryngol Head Neck Surg ; 143(5 Suppl 3): S9-14, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20970694

ABSTRACT

OBJECTIVE: Both clinical data and laboratory studies demonstrated the risk of pneumococcal meningitis post-cochlear implantation. This review examines strategies to prevent post-implant meningitis. DATA SOURCES: Medline/PubMed database; English articles after 1980. Search terms: cochlear implants, pneumococcus meningitis, streptococcus pneumonia, immunization, prevention. REVIEW METHODS: Narrative review. All articles relating to post-implant meningitis without any restriction in study designs were assessed and information extracted. RESULTS: The presence of inner ear trauma as a result of surgical technique or cochlear implant electrode array design was associated with a higher risk of post-implant meningitis. Laboratory data demonstrated the effectiveness of pneumococcal vaccination in preventing meningitis induced via the hematogenous route of infection. Fibrous sealing around the electrode array at the cochleostomy site, and the use of antibiotic-coated electrode array reduced the risk of meningitis induced via an otogenic route. CONCLUSION: The recent scientific data support the U.S. Food and Drug Administration recommendation of pneumococcal vaccination for the prevention of meningitis in implant recipients. Nontraumatic cochlear implant design, surgical technique, and an adequate fibrous seal around the cochleostomy site further reduce the risk of meningitis.


Subject(s)
Cochlear Implantation/adverse effects , Cochlear Implants/adverse effects , Ear, Inner/injuries , Meningitis, Pneumococcal/etiology , Meningitis, Pneumococcal/prevention & control , Prosthesis-Related Infections/etiology , Prosthesis-Related Infections/prevention & control , Anti-Bacterial Agents/administration & dosage , Drug Delivery Systems , Ear, Inner/pathology , Electrodes , Humans , Meningitis, Pneumococcal/microbiology , Pneumococcal Vaccines/administration & dosage , Prosthesis-Related Infections/microbiology , Risk Factors , Streptococcus pneumoniae
15.
J Control Release ; 141(2): 161-7, 2010 Jan 25.
Article in English | MEDLINE | ID: mdl-19788902

ABSTRACT

In this study the synergistic effect of delivering two neurotrophins simultaneously to encourage neuron survival and neurite elongation was explored. Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) were incorporated into polypyrrole (PPy) during electrosynthesis and the amounts incorporated and released were determined using iodine-125 ((125)I) radio-labelled neurotrophins. Neurite outgrowth from cochlear neural explants grown on the conducting polymer was equivalent to that on tissue culture plastic but significantly improved with the incorporation of NT-3 and BDNF. Neurite outgrowth from explants grown on polymers containing both NT-3 and BDNF showed significant improvement over PPy doped only with NT-3, due to the synergistic effect of both neurotrophins. Neurite outgrowth was significantly improved when the polymer containing both neurotrophins was electrically stimulated. It is envisaged that when applied to the cochlear implant, these conducting and novel polymer films will provide a biocompatible substrate for storage and release of neurotrophins to help protect auditory neurons from degradation after sensorineural hearing loss and encourage neurite outgrowth towards the electrodes.


Subject(s)
Brain-Derived Neurotrophic Factor/pharmacology , Cochlear Nerve/drug effects , Drug Carriers , Electric Stimulation , Neurites/drug effects , Neurotrophin 3/pharmacology , Polymers/chemistry , Pyrroles/chemistry , Animals , Animals, Newborn , Brain-Derived Neurotrophic Factor/chemistry , Cell Survival , Cochlear Nerve/growth & development , Drug Combinations , Drug Synergism , Electric Conductivity , Kinetics , Neurotrophin 3/chemistry , Rats , Rats, Wistar , Solubility , Tissue Culture Techniques
16.
Biomaterials ; 30(29): 5292-304, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19643473

ABSTRACT

Conducting polymers have been developed as substrates for in vitro studies with a range of cell types including electrically-excitable cells such as nerve and smooth muscle. The goal of this study was to optimise and characterise a range of polypyrrole materials to act as substrates for electrical stimulation of differentiating skeletal myoblasts. Although all of the polymer materials provided suitable substrates for myoblast adhesion and proliferation, significant differences became apparent under the low-serum conditions used for differentiation of primary myoblasts. The significance of the work lies in the design and control of polymer materials to facilitate different stages of skeletal muscle cell proliferation and/or differentiation, opening up opportunities for engineering of this tissue. This paper therefore constitutes not just a biocompatibility assessment but a comprehensive study of how synthesis conditions affect the final outcome in terms of cell response.


Subject(s)
Coated Materials, Biocompatible/chemistry , Extracellular Matrix/chemistry , Muscle Fibers, Skeletal/cytology , Muscle Fibers, Skeletal/physiology , Polymers/chemistry , Pyrroles/chemistry , Stem Cells/cytology , Stem Cells/physiology , Animals , Cell Adhesion , Cell Differentiation , Cell Proliferation , Cells, Cultured , Male , Materials Testing , Mice , Mice, Inbred C57BL , Mice, Transgenic , Surface Properties , Tissue Engineering/methods
17.
Biomaterials ; 30(13): 2614-24, 2009 May.
Article in English | MEDLINE | ID: mdl-19178943

ABSTRACT

Sensorineural hearing loss is associated with gradual degeneration of spiral ganglion neurons (SGNs), compromising hearing outcomes with cochlear implant use. Combination of neurotrophin delivery to the cochlea and electrical stimulation from a cochlear implant protects SGNs, prompting research into neurotrophin-eluting polymer electrode coatings. The electrically conducting polypyrrole/para-toluene sulfonate containing neurotrophin-3 (Ppy/pTS/NT3) was applied to 1.7 mm2 cochlear implant electrodes. Ppy/pTS/NT3-coated electrode arrays stored 2 ng NT3 and released 0.1 ng/day with electrical stimulation. Guinea pigs were implanted with Ppy/pTS or Ppy/pTS/NT3 electrode arrays two weeks after deafening via aminoglycosides. The electrodes of a subgroup of these guinea pigs were electrically stimulated for 8 h/day for 2 weeks. There was a loss of SGNs in the implanted cochleae of guinea pigs with Ppy/pTS-coated electrodes indicative of electrode insertion damage. However, guinea pigs implanted with electrically stimulated Ppy/pTS/NT3-coated electrodes had lower electrically-evoked auditory brainstem response thresholds and greater SGN densities in implanted cochleae compared to non-implanted cochleae and compared to animals implanted with Ppy/pTS-coated electrodes (p<0.05). Ppy/pTS/NT3 did not exacerbate fibrous tissue formation and did not affect electrode impedance. Drug-eluting conducting polymer coatings on cochlear implant electrodes present a clinically viable method to promote preservation of SGNs without adversely affecting the function of the cochlear implant.


Subject(s)
Cochlea/cytology , Nerve Growth Factors/chemistry , Nerve Growth Factors/metabolism , Neurons/metabolism , Polymers/chemistry , Pyrroles/chemistry , Animals , Electric Stimulation , Electrodes , Female , Guinea Pigs , Male , Prostheses and Implants
18.
J Biomed Mater Res A ; 91(1): 241-50, 2009 Oct.
Article in English | MEDLINE | ID: mdl-18814235

ABSTRACT

Release of neurotrophin-3 (NT3) and brain-derived neurotrophic factor (BDNF) from hair cells in the cochlea is essential for the survival of spiral ganglion neurons (SGNs). Loss of hair cells associated with a sensorineural hearing loss therefore results in degeneration of SGNs, potentially reducing the performance of a cochlear implant. Exogenous replacement of either or both neurotrophins protects SGNs from degeneration after deafness. We previously incorporated NT3 into the conducting polymer polypyrrole (Ppy) synthesized with para-toluene sulfonate (pTS) to investigate whether Ppy/pTS/NT3-coated cochlear implant electrodes could provide both neurotrophic support and electrical stimulation for SGNs. Enhanced and controlled release of NT3 was achieved when Ppy/pTS/NT3-coated electrodes were subjected to electrical stimulation. Here we describe the release dynamics and biological properties of Ppy/pTS with incorporated BDNF. Release studies demonstrated slow passive diffusion of BDNF from Ppy/pTS/BDNF, with electrical stimulation significantly enhancing BDNF release over 7 days. A 3-day SGN explant assay found that neurite outgrowth from explants was 12.3-fold greater when polymers contained BDNF (p < 0.001), although electrical stimulation did not increase neurite outgrowth further. The versatility of Ppy to store and release neurotrophins, conduct electrical charge, and act as a substrate for nerve-electrode interactions is discussed for specialized applications such as cochlear implants.


Subject(s)
Benzenesulfonates/chemistry , Brain-Derived Neurotrophic Factor/administration & dosage , Neurites/metabolism , Neurons/cytology , Polymers/chemistry , Pyrroles/chemistry , Tissue Engineering/instrumentation , Animals , Cells, Cultured , Cochlear Implants , Diffusion , Electric Stimulation , Electrodes , Equipment Design , Ganglia/cytology , Rats , Rats, Wistar , Spiral Ganglion
19.
Adv Mater ; 21(43): 4393-7, 2009 Nov 20.
Article in English | MEDLINE | ID: mdl-26042951

ABSTRACT

A biosynthetic platform composed of a conducting polypyrrole sheet embedded with unidirectional biodegradable polymer fibers is described (see image; scale bar = 50 µm). Such hybrid systems can promote rapid directional nerve growth for neuro-regenerative scaffolds and act as interfaces between the electronic circuitry of medical bionic devices and the nervous system.

20.
Adv Mater ; 21(43)2009 Nov 20.
Article in English | MEDLINE | ID: mdl-26042954

ABSTRACT

Effective functional innervation of medical bionic devices, as well as re-innervation of target tissue in nerve and spinal cord injuries, requires a platform that can stimulate and orientate neural growth. Gordon Wallace and co-workers report on p. 4393 that conducting and nonconducting biodegradable polymers show excellent potential as suitable hybrid substrata for neural regeneration and may form the basis of electrically active conduits designed to accelerate nerve repair.

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