ABSTRACT
A 55-year-old woman with recurrent glioblastoma multiforme on palliative chemotherapy including Avastin, an angiogenesis inhibitor, presents with several episodes of bacterial meningitis secondary to a persistent cerebrospinal fluid (CSF) leak. Anastomotic dehiscence of the dura mater in the region of the previous craniotomy sites was evident. Attempts to repair the cranial CSF leak with external ventricular drain and ventriculoperitoneal shunt were unsuccessful. This patient underwent repair of the dural defects with a radial forearm free fascial flap, with consequent resolution of the CSF leak.A literature search was performed, and the available data on angiogenesis inhibitors and anastomotic dehiscence was reviewed, specifically focusing on delayed anastomotic dehiscence in patients receiving Avastin (bevacizumab). Although the potential complications of anastomotic dehiscence in patients receiving angiogenesis inhibitors are well documented, there is comparatively little documentation in the literature regarding delayed wound or anastomotic dehiscence. Twenty such cases were found cited in the literature; however, only one study was found which specifically considered angiogenesis inhibitors within the context of central nervous system malignancies.
Subject(s)
Anastomotic Leak/surgery , Angiogenesis Inhibitors/adverse effects , Antibodies, Monoclonal, Humanized/adverse effects , Cerebrospinal Fluid Rhinorrhea/surgery , Craniotomy , Free Tissue Flaps/transplantation , Plastic Surgery Procedures/methods , Anastomotic Leak/chemically induced , Bevacizumab , Cerebrospinal Fluid Leak , Cerebrospinal Fluid Rhinorrhea/chemically induced , Female , Humans , Middle AgedABSTRACT
BACKGROUND: Umbilical herniorraphy is a common paediatric surgery day case. Paraumbilical blocks have previously been reported to provide excellent analgesia for umbilical hernia repairs. METHODS: Local anaesthesia through a paraumbilical block was compared with local infiltration. Postoperative analgesic requirements were used to gauge the effectiveness of the techniques. RESULTS: Patients receiving a paraumbilical block required significantly less analgesia postoperatively. These patients were generally discharged from hospital sooner. CONCLUSION: Paraumbilical block results in improved postoperative pain control through the more precise delivery of local anaesthetic to the intercostal nerves.
