Subject(s)
Antioxidants/pharmacology , Ethoxyquin/pharmacology , Glutathione/metabolism , Lipid Peroxidation/drug effects , Liver/drug effects , Liver/metabolism , Animals , Cell Membrane/drug effects , Cell Membrane/metabolism , In Vitro Techniques , Membrane Lipids/metabolism , Rats , Thiobarbituric Acid Reactive Substances/metabolismABSTRACT
Previous studies [Jackson et al. 1980] have shown that the bioavailability of Augmentin is not affected by food. The present work has shown that aluminum hydroxide, milk and cimetidine do have some influence on the bioavailability of a single dose of oral Augmentin, but the small differences observed are unlikely to be of therapeutic importance. It is concluded that Augmentin may be administered in clinical practice with any of these substances.
Subject(s)
Amoxicillin/metabolism , Clavulanic Acids/metabolism , Administration, Oral , Adult , Aluminum Hydroxide/pharmacology , Amoxicillin/administration & dosage , Amoxicillin-Potassium Clavulanate Combination , Animals , Cimetidine/metabolism , Clavulanic Acid , Clavulanic Acids/administration & dosage , Clavulanic Acids/blood , Drug Combinations , Drug Interactions , Humans , Metabolic Clearance Rate/drug effects , Milk/metabolismABSTRACT
The effect of probenecid on the combination of amoxycillin/clavulanic acid has been compared with the effect on amoxycillin alone and it has been shown that probenecid, whilst producing its expected effect on amoxycillin, did not affect the clavulanic acid concentration of the combination. A possible minor role for tubular secretion of clavulanic acid is discussed.
