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1.
Mult Scler Relat Disord ; 57: 103430, 2022 Jan.
Article in English | MEDLINE | ID: mdl-34922252

ABSTRACT

BACKGROUND: The thalamus and the putamen are highly connected hubs implicated in multiple sclerosis (MS) pathology. It remains unclear if white matter (WM) tracts, which pass through them, have a different susceptibility to MS pathology, and if so, if their impact on disability predominates over that exerted by disease in other WM tracts. We hypothesized that WM tracts connected to and passing through these hubs (subsequently termed hub+ tracts) would be more susceptible to MS-related pathology than tracts that do not pass through them (hub- tracts) due to retrograde and anterograde distant degeneration. Thus, we compared the lesion load and neurite orientation dispersion and density imaging (NODDI) derived metrics between hub+ and hub- tracts and assessed the relationship between these MRI metrics and those of physical impairment. METHODS: Eighteen patients (mean age of 45.5 years, 12 females) had 3 Tesla MRI consisting of T1-weighted and T2-weighted Fluid Attenuated Inversion Recovery (FLAIR), and NODDI from which the orientation dispersion index (ODI), neurite density index (NDI), and isotropic volume fraction (IVF) were derived. Forty-nine WM tracts, i.e., 12 hub+ and 37 hub- tracts, were segmented out. Exploratory analyses of the differences in lesion burden, whole tract and normal appearing WM (NAWM) NODDI metrics were carried out between the two types of tracts using a Mann-Whitney U test. Correlations with physical impairment, quantified using the expanded disability status scale (EDSS) and timed 25-foot walk (T25FW) test were assessed using Spearman correlation analyses. RESULTS: Hub- tracts had larger T1- (p<0.001) and T2-lesion (p<0.001) volumes; lower ODI (p<0.001), NDI (p<0.001) and higher IVF (p = 0.020) in comparison to hub+ tracts. Measures of tissue injury in hub+ tracts correlated with those of clinical disability, though less strongly than in hub- tracts. CONCLUSIONS: Contrary to our hypothesis, our exploratory pilot study results suggest that WM tracts that overlap with the thalamus and the putamen have a lower degree of lesional and non-lesional tissue injury, suggesting a protective role of the hubs against MS pathology or a higher degree of vulnerability of those not passing through hub stations. We also show a weaker association between disability impairment and hub+ pathology, compared to that in hub- tracts. Our findings point to a potential role of disease location in relation to hubs as guidance for treatment personalization in MS.


Subject(s)
Multiple Sclerosis , White Matter , Brain , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Multiple Sclerosis/diagnostic imaging , Pilot Projects , Putamen/diagnostic imaging , Thalamus/diagnostic imaging , White Matter/diagnostic imaging
2.
AJNR Am J Neuroradiol ; 41(6): 1001-1008, 2020 06.
Article in English | MEDLINE | ID: mdl-32439639

ABSTRACT

BACKGROUND AND PURPOSE: Previous studies have suggested that the central vein sign and iron rims are specific features of MS lesions. Using 3T SWI, we aimed to compare the frequency of lesions with central veins and iron rims in patients with clinically isolated syndrome and MS-mimicking disorders and test their diagnostic value in predicting conversion from clinically isolated syndrome to MS. MATERIALS AND METHODS: For each patient, we calculated the number of brain lesions with central veins and iron rims. We then identified a simple rule involving an absolute number of lesions with central veins and iron rims to predict conversion from clinically isolated syndrome to MS. Additionally, we tested the diagnostic performance of central veins and iron rims when combined with evidence of dissemination in space. RESULTS: We included 112 patients with clinically isolated syndrome and 35 patients with MS-mimicking conditions. At follow-up, 94 patients with clinically isolated syndrome developed MS according to the 2017 McDonald criteria. Patients with clinically isolated syndrome had a median of 2 central veins (range, 0-19), while the non-MS group had a median of 1 central vein (range, 0-6). Fifty-six percent of patients who developed MS had ≥1 iron rim, and none of the patients without MS had iron rims. The sensitivity and specificity of finding ≥3 central veins and/or ≥1 iron rim were 70% and 86%, respectively. In combination with evidence of dissemination in space, the 2 imaging markers had higher specificity than dissemination in space and positive findings of oligoclonal bands currently used to support the diagnosis of MS. CONCLUSIONS: A single 3T SWI scan offers valuable diagnostic information, which has the potential to prevent MS misdiagnosis.


Subject(s)
Brain/diagnostic imaging , Demyelinating Diseases/diagnostic imaging , Multiple Sclerosis/diagnostic imaging , Neuroimaging/methods , Adult , Aged , Brain/pathology , Demyelinating Diseases/pathology , Female , Humans , Image Interpretation, Computer-Assisted , Magnetic Resonance Imaging/methods , Male , Middle Aged , Multiple Sclerosis/pathology , Sensitivity and Specificity , Young Adult
3.
Appl Clin Inform ; 5(1): 169-90, 2014.
Article in English | MEDLINE | ID: mdl-24734131

ABSTRACT

BACKGROUND: With the increase in the adoption of electronic health records (EHR) across the US, primary care physicians are experiencing information overload. The purpose of this pilot study was to determine the information needs of primary care physicians (PCPs) as they review clinic visit notes to inform EHR display. METHOD: Data collection was conducted with 15 primary care physicians during semi-structured interviews, including a third party observer to control bias. Physicians reviewed major sections of an artificial but typical acute and chronic care visit note to identify the note sections that were relevant to their information needs. Statistical methods used were McNemar-Mosteller's and Cochran Q. RESULTS: Physicians identified History of Present Illness (HPI), Assessment, and Plan (A&P) as the most important sections of a visit note. In contrast, they largely judged the Review of Systems (ROS) to be superfluous. There was also a statistical difference in physicians' highlighting among all seven major note sections in acute (p = 0.00) and chronic (p = 0.00) care visit notes. CONCLUSION: A&P and HPI sections were most frequently identified as important which suggests that physicians may have to identify a few key sections out of a long, unnecessarily verbose visit note. ROS is viewed by doctors as mostly "not needed," but can have relevant information. The ROS can contain information needed for patient care when other sections of the Visit note, such as the HPI, lack the relevant information. Future studies should include producing a display that provides only relevant information to increase physician efficiency at the point of care. Also, research on moving A&P to the top of visit notes instead of having A&P at the bottom of the page is needed, since those are usually the first sections physicians refer to and reviewing from top to bottom may cause cognitive load.


Subject(s)
Ambulatory Care Information Systems , Ambulatory Care , Physicians, Primary Care , Acute Disease , Adult , Chronic Disease , Demography , Female , Follow-Up Studies , Humans , Male , Middle Aged
4.
J Neuroendocrinol ; 24(3): 511-24, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22175701

ABSTRACT

The perinatal environment can be crucial for programming long-term physiology, including the mechanisms regulating body weight, and postnatal overfeeding can lead to obesity throughout life. Inflammation-related complications are of particular concern in the obese. However, little is known about how postnatal overfeeding contributes to changes in the ability to respond to inflammation. In the present study, we investigate changes in the febrile and neurochemical response to immune challenge with lipopolysaccharide (LPS), in juvenile and adult, male and female Wistar rats made obese by overfeeding during the postnatal period. We demonstrate that febrile responses to LPS are exacerbated in these rats, with peak core temperatures being up to 0.5 °C higher compared to those in controls, and this is associated with an enhanced pro-inflammatory cytokine profile and enhanced hypothalamic-pituitary-adrenal (HPA) axis activation. Plasma pro-inflammatory cytokines concentrations were approximately three-fold greater in neonatally overfed rats after LPS and there were approximately twice as many neurones activated in the paraventricular nucleus of the hypothalamus as in controls, with a prolonged corticosterone response. We also observed elevated expression of toll-like receptors (TLR) 2 and 4 in adipose tissue and greater inhibitory factor κB phosphorylation in these obese animals. Despite similar changes in expression of adipose TLR3, there was no corresponding alteration in the response to a viral mimetic that acts at this receptor. We suggest that an elevated febrile response to LPS therefore occurs in cases of obesity and this is associated with altered HPA axis function and enhanced TLR2/4 expression in adipose tissue and an up-regulated downstream pro-inflammatory cascade.


Subject(s)
Energy Intake , Fever/chemically induced , Lipopolysaccharides/toxicity , Obesity/etiology , Absorptiometry, Photon , Animals , Animals, Newborn , Body Weight , Calorimetry , Cytokines/metabolism , Female , Fever/physiopathology , Hypothalamo-Hypophyseal System , Inflammation Mediators/metabolism , Male , Pituitary-Adrenal System , Pregnancy , Rats , Rats, Wistar , Real-Time Polymerase Chain Reaction , Reverse Transcriptase Polymerase Chain Reaction
5.
J Intellect Disabil Res ; 56(3): 233-47, 2012 Mar.
Article in English | MEDLINE | ID: mdl-21385260

ABSTRACT

BACKGROUND: While behavioural abnormalities are fundamental features of Rett syndrome (RTT), few studies have examined the RTT behavioural phenotype. Most of these reports have focused on autistic features, linked to the early regressive phase of the disorder, and few studies have applied standardised behavioural measures. We used a battery of standardised measures of behaviour and functioning to test the following hypotheses: (1) autistic behaviour is prominent throughout childhood in RTT; (2) autistic features are more salient in individuals with milder presentation; (3) severity of autistic behaviour is associated with a wider range of behavioural problems; and (4) specific MECP2 mutations are linked to more severe autistic behaviour. METHODS: Eighty MECP2 mutation-positive girls with RTT (aged 1.6-14.9 years) were administered: (1) the Screen for Social Interaction (SSI), a measure of autistic behaviour suited for individuals with severe communication and motor impairment; (2) the Rett Syndrome Behaviour Questionnaire (RSBQ), covering a wide range of abnormal behaviours in RTT; (3) the Vineland Adaptive Behavior Scales (VABS); and (4) a modified version of the Rett Syndrome Severity Scale (RSSS). Regression analyses examined the predictive value of age and RSSS on autistic behaviour and other behavioural abnormalities. T-tests further characterised the behavioural phenotype of individual MECP2 mutations. RESULTS: While age had no significant effect on SSI or RSBQ total scores in RTT, VABS Socialization and Composite scores decreased over time. Clinical severity (i.e. RSSS) also increased with age. Surprisingly, SSI performance was not related to either RSSS or VABS Composite scores. Autistic behaviour was weakly linked with the RSBQ Hand behaviour factor scores, but not with the RSBQ Fear/Anxiety factor. Clinical (neurological) severity did not predict RSBQ scores, as evidenced by the analysis of individual MECP2 mutations (e.g. p.R106W, p.R270X and p.R294X). CONCLUSIONS: Our data suggest that in RTT, autistic behaviour persists after the period of regression. It also demonstrated that neurological and behavioural impairments, including autistic features, are relatively independent of one another. Consistent with previous reports of the RTT phenotype, individual MECP2 mutations demonstrate complex associations with autistic features. Evidence of persistent autistic behaviour throughout childhood, and of a link between hand function and social skills, has important implications not only for research on the RTT behavioural phenotype, but also for the clinical management of the disorder.


Subject(s)
Regression, Psychology , Rett Syndrome/physiopathology , Social Behavior , Adolescent , Age Factors , Child , Child, Preschool , Cohort Studies , Female , Humans , Infant , Methyl-CpG-Binding Protein 2/classification , Methyl-CpG-Binding Protein 2/genetics , Mutation/genetics , Phenotype , Psychiatric Status Rating Scales , Rett Syndrome/classification , Rett Syndrome/genetics , Severity of Illness Index , Surveys and Questionnaires
6.
Philos Trans R Soc Lond B Biol Sci ; 366(1582): 3340-53, 2011 Nov 27.
Article in English | MEDLINE | ID: mdl-22006973

ABSTRACT

Long-term (21-30 years) erosional responses of rainforest terrain in the Upper Segama catchment, Sabah, to selective logging are assessed at slope, small and large catchment scales. In the 0.44 km(2) Baru catchment, slope erosion measurements over 1990-2010 and sediment fingerprinting indicate that sediment sources 21 years after logging in 1989 are mainly road-linked, including fresh landslips and gullying of scars and toe deposits of 1994-1996 landslides. Analysis and modelling of 5-15 min stream-suspended sediment and discharge data demonstrate a reduction in storm-sediment response between 1996 and 2009, but not yet to pre-logging levels. An unmixing model using bed-sediment geochemical data indicates that 49 per cent of the 216 t km(-2) a(-1) 2009 sediment yield comes from 10 per cent of its area affected by road-linked landslides. Fallout (210)Pb and (137)Cs values from a lateral bench core indicate that sedimentation rates in the 721 km(2) Upper Segama catchment less than doubled with initially highly selective, low-slope logging in the 1980s, but rose 7-13 times when steep terrain was logged in 1992-1993 and 1999-2000. The need to keep steeplands under forest is emphasized if landsliding associated with current and predicted rises in extreme rainstorm magnitude-frequency is to be reduced in scale.


Subject(s)
Climate Change , Geologic Sediments/chemistry , Trees/chemistry , Cesium Radioisotopes/analysis , Computer Simulation , Cyclonic Storms , Geologic Sediments/analysis , Landslides , Lead Radioisotopes/analysis , Malaysia , Rain/chemistry , Rivers/chemistry , Spectrometry, Gamma , Time Factors
8.
J Infect ; 44(3): 196-8, 2002 Apr.
Article in English | MEDLINE | ID: mdl-12099751

ABSTRACT

Candida parapsilosis endocarditis in association with prosthetic heart valves is rare. We report the first two cases of C. parapsilosis endocarditis on the Toronto stentless porcine valve (TSPV) and the first reported case of successful elimination of infection without lifelong antifungal therapy.


Subject(s)
Candida/isolation & purification , Candidiasis/diagnosis , Candidiasis/drug therapy , Endocarditis/drug therapy , Endocarditis/microbiology , Heart Valve Prosthesis/microbiology , Aged , Aged, 80 and over , Amphotericin B/therapeutic use , Animals , Antifungal Agents/therapeutic use , Candidiasis/microbiology , Endocarditis/surgery , Fluconazole/therapeutic use , Flucytosine/therapeutic use , Heart Valve Prosthesis/adverse effects , Humans , Male , Middle Aged , Swine
11.
Adv Exp Med Biol ; 434: 123-33, 1998.
Article in English | MEDLINE | ID: mdl-9598196

ABSTRACT

The chemical reactions contributing to sucrose loss and color formation in evaporators in sugar manufacture (i.e., hydrolysis of sucrose and degradation of monosaccharides at acid pH) are reviewed. A case study of a sugar factory's evaporator system demonstrates that the measurement of small but real losses of sucrose across the process is not possible by conventional sugar factory analyses. Alternative, more accurate techniques (e.g., capillary gas chromatography or high performance ion chromatography [HPIC] with pulsed amperometric detection [PAD]) are considered. In the case study, glucose:sucrose ratios are determined by HPIC, and sucrose loss across the evaporator is estimated to be 1.39% of total sucrose. Loss measurements are thought to be underestimates; reasons for underestimation and the sources of errors are discussed. An approach to a more definitive loss measurement is proposed.


Subject(s)
Dietary Sucrose/isolation & purification , Food Handling/methods , Color , Crystallization , Hydrogen-Ion Concentration , Hydrolysis , Oxidation-Reduction , Sucrose/chemistry
13.
Pediatrics ; 99(4): 567-74, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9093300

ABSTRACT

OBJECTIVES: To further define the clinical spectrum of the disease for pediatric and metabolic specialists, and to suggest that the general pediatrician and pediatric neurologist consider succinic semialdehyde dehydrogenase (SSADH) deficiency in the differential diagnosis of patients with (idiopathic) mental retardation and emphasize the need for accurate, quantitative organic acid analysis in such patients. PATIENTS: The clinical features of 23 patients (20 families) with SSADH deficiency (4-hydroxybutyric acid-uria) are presented. The age at diagnosis ranged from 3 months to 25 years in the 11 male and 12 female patients; consanguinity was noted in 39% of families. OUTCOME MEASUREMENTS: The following abnormalities were observed (frequency in 23 patients): motor delay, including fine-motor skills, 78%; language delay, 78%; hypotonia, 74%; mental delay, 74%; seizures, 48%; decreased or absent reflexes, 39%; ataxia, 30%; behavioral problems, 30%; hyperkinesis, 30%; neonatal problems, 26%; and electroencephalographic abnormalities, 26%. Associated findings included psychoses, cranial magnetic resonance or computed tomographic abnormalities, and ocular problems in 22% or less of patients. Therapy with vigabatrin proved beneficial to varying degrees in 35% of the patients. Normal early development was noted in 30% of patients. CONCLUSIONS: Our data imply that two groups of patients with SSADH deficiency exist, differentiated by the course of early development. Our recommendation would be that accurate, quantitative organic acid analysis in an appropriate specialist laboratory be requested for any patients presenting with two or more features of mental, motor, or language delay and hypotonia of unknown cause. Such analyses are the only definitive way to diagnose SSADH deficiency; the diagnosis can be confirmed by determination of enzyme activity in white cells from whole blood. We think that increased use of organic acid determination will lead to increased diagnosis of SSADH deficiency and a more accurate representation of disease frequency. As additional patients are identified, we should have a better understanding of both the metabolic and clinical profiles of SSADH deficiency.


Subject(s)
Aldehyde Oxidoreductases/deficiency , Intellectual Disability/etiology , Sodium Oxybate/urine , Adolescent , Adult , Child , Child, Preschool , Developmental Disabilities/etiology , Diagnosis, Differential , Enzyme Inhibitors/therapeutic use , Female , Humans , Infant , Language Development Disorders/etiology , Male , Metabolism, Inborn Errors/classification , Metabolism, Inborn Errors/complications , Metabolism, Inborn Errors/diagnosis , Metabolism, Inborn Errors/drug therapy , Motor Skills , Succinate-Semialdehyde Dehydrogenase , Vigabatrin , gamma-Aminobutyric Acid/analogs & derivatives , gamma-Aminobutyric Acid/therapeutic use
14.
Int J Clin Pract ; 51(6): 414-5, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9489079

ABSTRACT

Adenomyoepithelioma is a rare disorder characterised by simultaneous proliferation of ductal epithelium and myoepithelial cells. It is more common in salivary glands or skin, and only rarely found in breast tissue. Adenomyoepithelioma of the breast was first described in 1970 by Hamperl. Since then, approximately 55 cases have been described in the literature; the largest review, by Tavassoli in 1991, reported 27 of these cases. Because of the small number of cases reported, the natural history of adenomyoepithelioma of the breast remains uncertain. We report a further case which was treated by local excision, and follow-up for two years has revealed no evidence of local recurrence or metastatic spread.


Subject(s)
Breast Neoplasms/diagnosis , Carcinoma/diagnosis , Adult , Female , Humans
15.
Arch Dis Child ; 74(3): 244-6, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8787433

ABSTRACT

A mother and daughter with an initial diagnosis of tuberous sclerosis are described. The daughter presented with partial seizures at the age of 8 months. Computed tomography showed uncalcified periventricular nodules which on magnetic resonance imaging were ovoid, almost contiguous, of grey matter density, and did not enhance with gadolinium. Brain imaging of her asymptomatic mother was similar. Absence of severe mental retardation, extracranial hamartomas, and depigmented patches distinguishes familial bilateral periventricular nodular heterotopia (FNH) from tuberous sclerosis. FNH is probably inherited as an X linked dominant with lethality in males.


Subject(s)
Brain Diseases/diagnosis , Cerebral Ventricles , Choristoma/diagnosis , Tuberous Sclerosis/diagnosis , Adult , Brain Diseases/genetics , Choristoma/genetics , Diagnosis, Differential , Female , Humans , Infant , Magnetic Resonance Imaging , Tomography, X-Ray Computed
16.
Clin Genet ; 44(5): 249-53, 1993 Nov.
Article in English | MEDLINE | ID: mdl-8313622

ABSTRACT

Two cases are described which presented with diffuse swelling of one cheek and hypertrophy of the underlying maxilla and mandible. Both children developed verrucous pigmented streaks over the area of swelling, and had epilepsy and severe mental subnormality. One of the children had a contralateral hemiplegia and his condition had a progressive course. The other child had no focal neurological signs and his disease seemed to be non-progressive. Although the facial appearance of both children suggested the diagnosis of encephalocrainiocutaneous lipomatosis syndrome, it was not possible to demonstrate the presence of any lipomata in either case. The literature relating to encephalocraniocutaneous lipomatosis is reviewed, as well as that relating to the syndromes of naevus unius lateris, the Proteus syndrome and the syndrome of cranial hemihypertrophy, and the clinical features of our two cases are compared with the features of these four syndromes.


Subject(s)
Epilepsy/complications , Facial Asymmetry/complications , Intellectual Disability/complications , Pigmentation Disorders/complications , Skull/abnormalities , Brain/abnormalities , Brain/diagnostic imaging , Diagnosis, Differential , Humans , Hypertrophy , Infant, Newborn , Male , Mandible/abnormalities , Maxilla/abnormalities , Skull/diagnostic imaging , Syndrome , Tomography, X-Ray Computed
17.
Arch Dis Child ; 69(4): 453-4, 1993 Oct.
Article in English | MEDLINE | ID: mdl-8259881

ABSTRACT

A boy with Duchenne muscular dystrophy and facial dysmorphism in conjunction with Klinefelter's genotype 47XXY is presented; this is an unusual situation with two genetic errors evolving over two generations. Karyotyping should be considered in boys with Duchenne muscular dystrophy who have unusual features.


Subject(s)
Klinefelter Syndrome/complications , Muscular Dystrophies/complications , Child, Preschool , Family Health , Genotype , Humans , Karyotyping , Klinefelter Syndrome/genetics , Male , Muscular Dystrophies/genetics , Pedigree
18.
Clin Radiol ; 47(4): 255-8, 1993 Apr.
Article in English | MEDLINE | ID: mdl-8495572

ABSTRACT

Dysembryoplastic neuroepithelial tumour (DNT) represents a morphologically unique and surgically treatable benign lesion typically associated with complex partial seizures (CPS). Although the radiological features are not pathognomonic the histology is quite distinct. They may account for a significant minority of children with intractable CPS. We present four histologically proven cases to demonstrate and discuss the range of radiological features. Recent recognition that CPS may be caused by a number of conditions including DNT emphasizes that all children with partial seizures should have radiological investigations early in their course.


Subject(s)
Brain Neoplasms/complications , Brain Neoplasms/diagnostic imaging , Epilepsy, Complex Partial/etiology , Brain/diagnostic imaging , Brain Neoplasms/pathology , Child , Child, Preschool , Female , Humans , Infant , Male , Tomography, X-Ray Computed
19.
Seizure ; 1(2): 75-7, 1992 Jun.
Article in English | MEDLINE | ID: mdl-1344332

ABSTRACT

We present three cases of fatal hepatic necrosis in patients with epilepsy taking anticonvulsants, in which the terminal illness presented as an unusually severe generalized tonic-clonic seizure with failure to regain consciousness. In two cases acute renal failure also occurred. It is not certain to what extent drug therapy, physiological and metabolic changes consequent on prolonged seizures, hitherto undiscovered infective agents, or a combination of any of these may play in such a process. We suggest, however, that the case against the drugs alone has yet to be proved.


Subject(s)
Epilepsy, Tonic-Clonic/etiology , Epilepsy/complications , Liver Failure, Acute/etiology , Acidosis/etiology , Adult , Anticonvulsants/adverse effects , Anticonvulsants/therapeutic use , Child , Epilepsy/drug therapy , Fatal Outcome , Humans , Kidney Tubular Necrosis, Acute/chemically induced , Kidney Tubular Necrosis, Acute/etiology , Liver/pathology , Liver Failure, Acute/chemically induced , Liver Failure, Acute/pathology , Liver Function Tests , Male , Necrosis/pathology
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