[Prognostic predictive value of neonatal ultrasonic studies of the CNS and of EEG monitoring for the psychomotor development at 1 year of age]. / Der prognostische Aussagewert der neonatalen Ultraschall-Untersuchung des ZNS und des EEG-Monitorings für die statomotorische Entwicklung im Alter von 1 Jahr.

The prognostic value of cranial ultrasound and EEG-monitoring for the developmental outcome at 1 year of age in 209 premature and full-term newborns was studied retrospectively. The first ultrasound examination was performed within the first three days of life. Further investigations were done depending on type of severity of the findings. The investigation was completed by EEG-monitoring in 41 patients. The infants were investigated for psychomotor development. 158 infants were found normally developed. Abnormal neonatal ultrasound findings were registered in 18.9% of them. Developmental retardation was observed in 46 infants. 54.3% of them had abnormal ultrasound findings. 2/3 of infants with neonatal major brain insults like IVH III-IV or leukomalacia showed serious neurological handicaps, whereas subependymal bleedings seem to be without influence onto the development. In contrast pathologic EEG's were of higher prognostic value. None of the infants with a abnormal EEG was developed normally.

[Studies on the predictive value and prognostic significance of compliance measurements in artificially ventilated newborn infants]. / Untersuchungen zur klinischen Aussagefähigkeit und prognostichen Bedeutung der Compliancemessung bei beatmeten Frühgeborenen.

In 29 mechanical ventilated preterm infants the compliance of the respiratory system (Crs) was determined. Newborn infants with severe respiratory distress syndrome show a decreased Crs. A significant correlation could be proved between the Crs and the pCO2 as well as the inspiratory pressure. The second estimation of the Crs after 48 hours refers to the prognosis of the ventilated newborn infants.

EEG spectral analysis in newborns with and without severe brain damage at different conceptional ages. A preliminary report.

Spectral power (SP) analysis of neonatal discontinuous EEG pattern of bilateral Fp-T and T-0 derivations has been performed in 5 newborns with no or mild brain damage and in 5 newborns with severe brain damage matched for conceptional age (30-39, week). Discontinuous EEG was separated in interburst and burst intervals. SP of all frequency bands was depressed in newborns with severe brain damage, with the depression being more pronounced during interburst intervals. Surprisingly, a prominent depression of the SP of the derivations of the right hemisphere and of the delta frequency bands of severely handicapped newborns was found. Calculation of coherence between homologous bipolar derivations does not improve the possibilities to separate both groups.

[Congenital myotonic dystrophy]. / Kongenitale myotone Dystrophie.

By means of a casuistic the set of problems in congenital myotonia dystrophica is demonstrated. Own results are discussed.