ABSTRACT
Two polymorphs, (I) and (II), of (S)-{2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihy-droxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-deca-hydro-1H-cyclo-penta-[a]phenanthren-17-yl]-2-oxoeth-yl} 2,2-di-methyl-propane-thio-ate, C26H38O5S, have been identified. They are ortho-rhom-bic, non-centrosymmetric (P212121). The structures display layers of mol-ecules conected via O-Hâ¯O hydrogen bonds along the b-axis direction in polymorph (I) and along the c-axis direction in polymorph (II). The structure of (II) exhibits disorder of the main mol-ecule.
ABSTRACT
The title compound, C11H11FO2, is a building block in the synthesis of the active pharmaceutical ingredient dl-nebivolol. The synthesis starting from the enanti-omerically pure (R)-6-fluoro-4-oxo-3,4-di-hydro-2H-chromene-2-carb-oxy-lic acid resulted in a mixture of two stereoisomers, namely (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman and (R)-6-fluoro-2-[(R)-oxiran-2-yl]chroman. The mixture was separated by column chromatography but only one stereoisomer crystallized. The X-ray structure analysis revealed that the solid consisted of the R,S isomer. A similar procedure was repeated for (S)-6-fluoro-4-oxo-3,4-di-hydro-2H-chromene-2-carb-oxy-lic acid and, in this case, the S,R isomer was produced as a crystalline solid. Thus, all four stereoisomers of the title epoxide were obtained and their absolute configuration was assigned. The crystal studied was refined as an inversion twin.
ABSTRACT
The structure of the title compound [alternatively called (R)-(-)-1-aza-bicyclo-[2.2.2]octan-3-ol], C7H13NO, at 100â K has hexa-gonal (P61) symmetry. The structure shows a twist along the C-N pseudo-threefold axis. In the crystal, mol-ecules are linked via O-Hâ¯N hydrogen bonds, forming infinite chains along the c-axis direction. The crystal studied was twinned by merohedry (twin law: 010, 100, 00-1; population: 0.925:0.075).
ABSTRACT
The title salt, C18H21FNO2 (+)·Br(-), determined at 115â K, crystallizes in the triclinic space group P1. The previously reported polymorph occurs in the monoclinic space group P21 and has two independent mol-ecules in the asymmetric unit [Peeters et al. (1993 â¶). Acta Cryst. C49, 2157-2160]. In the title molecule, the pyran rings adopt half-chair conformations. The absolute configuration is S for the hy-droxy-bearing C atom and R for the asymmetric C atom in the di-hydro-pyran unit. In the crystal, the components are linked by N-Hâ¯Br and O-Hâ¯Br hydrogen bonds, forming chains along the c-axis direction. The crystal studied was refined as an inversion twin.
ABSTRACT
The asymmetric unit of the title hydrated salt, C22H26F2NO4(+)·Cl(-)·0.5H2O, consists of an (S,S,S,S)-nebivolol {nebivol = bis-[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hy-droxy-eth-yl]ammonium} cation, a chloride anion and a half-occupancy water mol-ecule. The dihedral angle between the mean planes of the benzene rings is 50.34â (12)°. The pyran rings adopt half-chair conformations. The crystal packing features O-Hâ¯O hydrogen bonds and weak N-Hâ¯Cl, O-Hâ¯Cl, and O-Hâ¯Cl inter-actions, producing layers along (010).