ABSTRACT
Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellular peroxisomal proliferation and hepatic cellular proliferation are factors in chronic liver response to dietary dosing, that lowering of serum total cholesterol is an early clinical measure of response to treatment, and that liver and serum PFOS concentrations are proportional to dose and cumulative dose after sub-chronic treatment. PFOS was administered in diet as the potassium salt at 0, 0.5, 2.0, 5.0, and 20 parts per million (ppm) to Sprague Dawley rats for 4 or 14 weeks. At 4 weeks, effects included decreased serum glucose and an equivocal (Subject(s)
Alkanesulfonic Acids/toxicity
, Fluorocarbons/toxicity
, Alanine Transaminase/blood
, Alkanesulfonic Acids/administration & dosage
, Animals
, Blood Chemical Analysis
, Body Weight
, Cholesterol/blood
, Dose-Response Relationship, Drug
, Female
, Fluorocarbons/administration & dosage
, Hematologic Tests
, Hepatocytes/enzymology
, Hepatocytes/metabolism
, Hepatocytes/pathology
, Liver/drug effects
, Liver/enzymology
, Liver/metabolism
, Liver/pathology
, Male
, No-Observed-Adverse-Effect Level
, Organ Size
, Oxidoreductases/biosynthesis
, Oxidoreductases/metabolism
, Proliferating Cell Nuclear Antigen/metabolism
, Rats
, Rats, Sprague-Dawley
, Urinalysis
