Subject(s)
Hospitals, Animal , Security Measures , Veterinary Medicine , Animals , Facility Design and ConstructionSubject(s)
Aggression , Dogs , Sports , Animals , Behavior, Animal , Dog Diseases/epidemiology , Dogs/genetics , Dogs/physiology , Female , Humans , Intestinal Diseases, Parasitic/epidemiology , Intestinal Diseases, Parasitic/veterinary , Male , United States , Wound Infection/epidemiology , Wound Infection/veterinary , Wounds and Injuries/epidemiology , Wounds and Injuries/veterinaryABSTRACT
The intravenous administration of dimethyl sulfoxide (100 mg/kg) resulted in a significant increase in cardiac output, stroke volume, central venous pressure, and a significant decrease in heart rate. Acupuncture by electrocautery at Jen Chung (Go-26) produced a significant increase in cardiac output, stroke volume, heart rate, mean arterial pressure, and pulse pressure and a significant decrease in total peripheral resistance in dogs under 0.75% halothane anesthesia. Both DMSO and acupuncture elicit an analgesic effect and enhance cardiovascular function as exemplified by an increase in the cardiac output.
Subject(s)
Acupuncture Therapy , Cardiovascular System/drug effects , Dimethyl Sulfoxide/pharmacology , Animals , Blood Pressure/drug effects , Cardiac Output/drug effects , Dogs , Heart Rate/drug effects , Pulse/drug effects , Stroke Volume/drug effects , Vascular Resistance/drug effectsSubject(s)
Dog Diseases/surgery , Fistula/veterinary , Malocclusion/veterinary , Mouth/surgery , Nasal Cavity/surgery , Animals , Dogs , Endodontics , Fistula/surgery , Malocclusion/surgeryABSTRACT
The cardiovascular effects of lysine acetylsalicylate and/or propranolol were studied in 26 dogs. All animals were maintained under anaesthesia with halothane 0.75 per cent, supplemented by the intravenous administration of succinylcholine to allow controlled ventilation during a two hour period of monitoring. Cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, Paco2, pao2 and base deficit were measured in each dog. Lysine acetylsalicylate 50 mg . kg-1, administered alone as a single bolus, significantly (P less than 0.05) increased the cardiac output and stroke volume and significantly decreased the heart rate, central venous pressure and total peripheral resistance in dogs under halothane anaesthesia. Propranolol hydrochloride 0.5 mg . kg-1 as a single intravenous bolus was followed by a significant decrease in cardiac output, heart rate and mean arterial pressure and a significant increase in central venous pressure and total peripheral resistance. The administration of propranolol prior to lysine acetylsalicylate resulted in a significant decrease in cardiac output and heart rate. Pretreatment with propranolol was effective in inhibiting the positive inotropic effect of lysine acetylsalicylate.
Subject(s)
Anesthesia, General , Aspirin/analogs & derivatives , Halothane , Hemodynamics/drug effects , Lysine/analogs & derivatives , Propranolol/pharmacology , Animals , Aspirin/antagonists & inhibitors , Blood Pressure/drug effects , Cardiac Output/drug effects , Dogs , Heart Rate/drug effects , Lysine/antagonists & inhibitors , Stroke Volume/drug effects , Vascular Resistance/drug effectsABSTRACT
Ether, ethanol and aqueous extracts of ginseng were serially prepared from Korean ginseng plants. Each extract in the dose of 40 mg/kg was administered intravenously to ten dogs under light halothane anesthesia while 11 cardiovascular variables were compared during the ensuing two hours. The variable included cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, PaCO2, PaO2 and base deficit. Following the administration of the ether extract (40 mg/kg) the heart rate and the central venous pressure decreased significantly. The administration of ethanol extract (40 mg/kg) caused a significant decrease in the heart rate and the mean arterial pressure. After the administration of the aqueous extract (40 mg/kg) the cardiac output, stroke volume and central venous pressure were significantly decreased, while the total peripheral resistance was significantly increased.
Subject(s)
Cardiovascular System/drug effects , Dogs/physiology , Panax/analysis , Plants, Medicinal , Animals , Cardiovascular Physiological Phenomena , Ethanol , Ether , Plant Extracts/pharmacology , WaterABSTRACT
The cardiovascular effects of morphine sulphate and/or acupuncture by means of electrocautery at Jen Chung (Go-26) were studied in 35 dogs. All animals were maintained under anaesthesia with halothane 0.75 per cent supplemented by the intravenous administration of succinylcholine to allow controlled ventilation during a two hour period of monitoring. Cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, [H+] (pH) PaCO2, PaO2 and base deficit were measured in each dog. Morphine 0.5 mg . kg-1, administered alone as a single bolus, significantly (P less than 0.05) decreased cardiac output, heart rate, mean arterial pressure, and significantly increased stroke volume and pulse pressure in dogs under halothane anaesthesia. Acupuncture by electrocautery alone induced a significant increase in cardiac output, stroke volume, heart rate, mean arterial pressure and pulse pressure with a significant decrease in total peripheral resistance following halothane. Acupuncture at Jen Chung (Go-26) for 10 minutes following the intravenous administration of morphine caused a significant increase in cardiac output, heart rate and mean arterial pressure with a significant decrease in central venous pressure and total peripheral resistance during halothane anaesthesia. The depressant effect of morphine on cardiac output, heart rate and mean arterial pressure in dogs under halothane anaesthesia appears to be reversed by acupuncture by electrocautery at Jen Chung (Go-26). Stimulation of this acupuncture locus could be helpful in resuscitating patients whose cardiovascular system is depressed by morphine and/or halothane anaesthesia.
Subject(s)
Acupuncture Therapy , Anesthesia , Cardiovascular System/drug effects , Morphine/pharmacology , Animals , Dogs , Halothane , Hemodynamics/drug effects , Sympathetic Nervous System/physiologyABSTRACT
The cardiovascular effects of the administration of sodium salicylate (100 mg/kg), the administration of morphine sulfate (0.5 mg/kg) and acupuncture by electrocautery at Jen-Chung (Go-26) were compared in groups of dogs under 0.75% halothane anesthesia. Cardiac output (CO), stroke volume (SV), heart rate (HR), mean arterial pressure (MAP), pulse pressure (PP), central venous pressure (CVP), total peripheral resistance (TPR), pH, PaCO2, PaO2 and base deficit were measured over a two hour period. A significant increase in CO, SV, PP, and CVP in addition to a significant decrease in TPR were observed following the administration of sodium salicylate. Morphine sulfate decreased the CO, HR, and MAP significantly while the SV and PP were significantly increased. Acupuncture by electrocautery at Jen-Chung (Go-26) produced a significant increase in CO, SV, HR, MAP, and PP and a significant decrease in TPR. This model was satisfactory in comparing cardiovascular changes evoked by a mild analgesic, sodium salicylate, a potent opiate, morphine sulfate, and acupuncture by electrocautery at Jen-Chung (Go-26).
Subject(s)
Acupuncture Therapy , Hemodynamics , Morphine/pharmacology , Sodium Salicylate/pharmacology , Animals , Blood Pressure/drug effects , Cardiac Output/drug effects , Dogs , Heart Rate/drug effects , Hemodynamics/drug effects , Stroke Volume/drug effectsABSTRACT
Forty dogs were studied during MAC-1 halothane anesthesia with a chronically implanted electromagnetic flow probe on the ascending aorta. Cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure and total peripheral resistance were determined in addition to Pao2, pH, Paco2 and base deficit. Acupuncture moxibustion with electrocautery at Jen Chung (Go-26) produced a significant (five per cent level) increase in the cardiac output, stroke volume, heart rate, mean arterial pressure and pulse pressure and a significant decrease in total peripheral resistance during a 120-minute period of observation in dogs under halothane anaesthesia. Acupuncture moxibustion at Go-26 following pretreatment with the narcotic antagonist naloxone (1 mg.kg-1) produced a significant increase in cardiac output, heart rate, mean arterial pressure. It is concluded that naloxone, which inhibits the analgesic effects of acupuncture, does not inhibit the symphathomimetic effect of acupuncture or moxibustion at Jen Chung (Go-26) in dogs under light MAC-1 halothane anaesthesia.
Subject(s)
Acupuncture Therapy , Hemodynamics/drug effects , Naloxone/pharmacology , Animals , Blood Pressure/drug effects , Cardiac Output/drug effects , Central Venous Pressure/drug effects , Dogs , Heart Rate/drug effects , Pulse/drug effects , Stroke Volume/drug effectsABSTRACT
An electromagnetic flowmeter probe was chronically implanted around the ascending aorta in a group of dogs. Subsequently, ten dogs were lightly anesthetized with halothane (0.75%), and a second (ethanol) extract of ginseng (40 mg/kg) was administered intravenously. Five dogs were anesthetized without the administration of ginseng. Eleven cardiovascular variables including cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, PaCO2, PaO2, and base deficit were compared for two hours. The heart rate and mean arterial pressure were significantly decreased following ginseng. There were no other meaningful changes in either group.
Subject(s)
Hemodynamics/drug effects , Panax , Plant Extracts/pharmacology , Plants, Medicinal , Anesthesia, Inhalation , Animals , Blood Pressure/drug effects , Depression, Chemical , Dogs , Ethanol , Halothane , Heart Rate/drug effects , RheologyABSTRACT
An electromagnetic flowmeter probe was chronically implanted around the ascending aorta in a group of dogs. Subsequently, ten dogs were lightly anesthetized with halothane (0.75%) and the third (aqueous) extract of ginseng (40 mg/kg) was administered intravenously. Five dogs were anesthetized without the administration of ginseng. Eleven cardiovascular variables including cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, PaCO2, PaO2, and base deficit were compared. The cardiac output, stroke volume, and central venous pressure were decreased significantly, while total peripheral resistance was increased significantly following ginseng.
Subject(s)
Hemodynamics/drug effects , Panax , Plant Extracts/pharmacology , Plants, Medicinal , Anesthesia, Inhalation , Animals , Blood Pressure/drug effects , Cardiac Output/drug effects , Dogs , Halothane , Rheology , Stroke Volume/drug effects , Vascular Resistance/drug effects , WaterABSTRACT
Ten (10) dogs were maintained under 0.75% halothane anesthesia while 11 cardiovascular parameters were studied before and following intravenous administration of an extract prepared from deer antlers. The eleven variables including cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, PaCO2, PaO2 and base line deficit were studied. Stroke volume was consistently elevated during the period of observation and significantly elevated at two time intervals. Other values were not altered significantly. Extract from deer antlers does not appear to have a great acute effect on the cardiovascular system of this animal model.
