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Recent advances in combinatorial chemistry applied to development of anti-HIV drugs.
Pettersson, S; Clotet-Codina, I; Esté, J A; Borrell, J I; Teixidó, J.
Mini Rev Med Chem ; 6(1): 91-108, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16457634

ABSTRACT

A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with high throughput screening assays has allowed the discovery and optimization of novel lead anti-HIV compounds.


Subject(s)
Anti-HIV Agents/chemical synthesis , Combinatorial Chemistry Techniques/methods , Anti-HIV Agents/chemistry , Anti-HIV Agents/pharmacology , HIV/drug effects , HIV/physiology , HIV Fusion Inhibitors/chemical synthesis , HIV Integrase Inhibitors/chemical synthesis , HIV Protease Inhibitors/chemical synthesis , Humans , Molecular Structure , Reverse Transcriptase Inhibitors/chemical synthesis
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