Subject(s)
Amino Acids/metabolism , Arteriosclerosis/metabolism , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
By the emission spectrographic analysis, we have searched the following oligoelements: Mn, Cd, Cu, Be, Cr, Ge, Nb, Ga, Zr, W, Pb, Sn, As, Zn, Ag, Sb, Ni, Bi, Co, Mo, and V, in the aortic arterial blood, in the caval, portal and suprahepatic vein blood, in ascite and in the bile, in control and in intoxicated dogs with dimethylnitrosamine (DMNA). Be, Ge, Nb, Ga, W, As, Sb were never found. Increased values of Cu, Mn, Pb, Zn, Ni, Co, Mo and V were noticed. The differences between the values obtained at intoxicated dogs against the control dogs were sometimes clear; at other times they were equal. This is the case of Ag in the aortic and suprahepatic vein blood and in the bile. In the portal vein blood Zn exceeds almost two times the values obtained in the intoxicated dogs. Also in the portal vein blood, Mo is almost three times more in the control dogs than in the intoxicated ones. But, generally, the values of the controls are below those found by the intoxicated dogs.
Subject(s)
Hepatitis/physiopathology , Liver Cirrhosis/physiopathology , Liver/analysis , Metals/analysis , Animals , Bile/analysis , Chemical and Drug Induced Liver Injury/etiology , Chronic Disease , Dimethylnitrosamine , Disease Models, Animal , Dogs , Liver Cirrhosis/chemically induced , Metals/bloodABSTRACT
One third of 160 operatives working in a permanently noisy industrial environment, within the range of 63-8000 Hz and intensity of sound of about 100 db, were found to suffer from a syndrome of neurocirculatory asthenia and 8.1% from arterial hypertension. Study of the ECG according to the criteria of the Minnesota code showed an increased frequency of upward deflection of ST segment (index 9-2) in 20.6% of the cases, depression of the ST segment with an ascending orientation in 50.62% of the cases and left ventricular hypertrophy (index 3-1 and 3-3) in 20% of the cases. Audiometry revealed loss of hearing at frequencies of 4000 CS in 16.1% of the cases. The results obtained suggest that the detrimental effects are not restricted only to hearing, but also that the alterations detected might evolve towards organic cardiac disorders.
