ABSTRACT
An unusual case of Castleman's disease (CD) restricted to the left cervical area is reported. CD is rarely confined to the cervical area; when it occurs, it is usually of the hyaline-vascular subtype and small in size. This case was atypical due to its histology (plasma-cell variant), big size (15 x 11 x 6 cm) and the absence of general symptoms. In spite of surgical excision, the disease recurred 11 months later. However, subsequent surgery followed by chemotherapy resulted in a long-lasting control of the disease.
Subject(s)
Castleman Disease/pathology , Head and Neck Neoplasms/pathology , Adult , Castleman Disease/drug therapy , Castleman Disease/surgery , Combined Modality Therapy , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/surgery , Humans , MaleABSTRACT
We have compared the efficacy josamycin (750 mg/12 h/orally) versus penicillin V (500 mg/8 h) for the treatment of acute tonsillitis in a prospective randomized study. Of the 82 eligible patients, 18 were diagnosed of infectious mononucleosis and excluded and the remaining 64 could be evaluated. The duration of the fever and the clinical evolution was similar away the 31 randomized to receive josamycin and the 27 treated with penicillin. In conclusion, josamycin seems to be a useful alternative to penicillin for the treatment of acute tonsillitis.
Subject(s)
Josamycin/therapeutic use , Penicillin V/therapeutic use , Tonsillitis/drug therapy , Acute Disease , Administration, Oral , Adult , Bacteria/isolation & purification , Female , Humans , Josamycin/administration & dosage , Male , Penicillin V/administration & dosage , Prospective Studies , Tonsillitis/microbiologyABSTRACT
The number of cases of NSA is increasing owing to a better knowledge of the disease and the high number of patients with impaired immunologic defense mechanism. Two cases are presented. A valoration of the different diagnostic and therapeutic procedures and also the different etiologic and clinical possibilities is done.
Subject(s)
Aspergillosis , Ethmoid Sinusitis/microbiology , Maxillary Sinusitis/microbiology , Amphotericin B/therapeutic use , Aspergillosis/diagnosis , Aspergillosis/surgery , Chronic Disease , Combined Modality Therapy , Diagnosis, Differential , Ethmoid Sinusitis/diagnosis , Ethmoid Sinusitis/drug therapy , Ethmoid Sinusitis/surgery , Female , Humans , Immunocompromised Host , Male , Maxillary Neoplasms/diagnosis , Maxillary Sinusitis/diagnosis , Maxillary Sinusitis/surgery , Middle Aged , Neutropenia/complications , Radiotherapy/adverse effectsABSTRACT
The authors studied the immunophenotype of nine sinonasal lymphomas using a panel of monoclonal antibodies that react with fixed, paraffin-embedded material (EMA, CAM 5.2, CD45, CD37 [MB-1], MB-2, L-26, CDw75 [LN-1], CD45RA [4 KB-5], CD43 [MT-1], and CD45RO [UCHL-1]). There were seven men and two women, with a mean age of 64 years (range, 9-89 years) and median age of 56 years. Three tumors were limited to the nasal cavity, and the other six had multiple sites of involvement, including the nasal cavity (five), antrum (six), ethmoid (two), orbit (two), and hard palate (one). Histologically, one was a lymphoblastic lymphoma (LBL), one was small cleaved-cell lymphoma (SCCL), three were mixed-cell lymphomas (MCLs), and four were large cell lymphomas (LCLs). Four cases were T-cell lymphomas (one SCCL, three MCLs), four were B-cell neoplasms (four LCLs), and one was of uncertain lineage (LBL). Angioinvasion, coagulative necrosis, and epitheliotropism were seen in the T-cell lymphomas. Extranasal dissemination was seen in four cases: one LBL that involved the lymph nodes, skin, and testes 15 months after diagnosis; one B-LCL that involved the skin 9 months after diagnosis; and one B-LCL and one T-MCL that involved the gastric mucosa and lung simultaneously with nasal presentation. This study shows a higher predominance of B-cell lymphomas in the sinonasal region than previously reported in Oriental populations. However, the T:B ratio of these lymphomas is still greater than that observed for primary lymph node-based neoplasms.
Subject(s)
Lymphoma, Non-Hodgkin/pathology , Nasal Cavity , Nose Neoplasms/pathology , Paranasal Sinus Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Immunohistochemistry , Lymphoma, Non-Hodgkin/immunology , Lymphoma, Non-Hodgkin/metabolism , Male , Middle Aged , Neoplasm Invasiveness , Nose Neoplasms/immunology , Nose Neoplasms/metabolism , Paranasal Sinus Neoplasms/immunology , Paranasal Sinus Neoplasms/metabolism , PhenotypeABSTRACT
Two cases of cholesteatoma of the facial sinuses are presented. One of them was located in the maxillary sinus and the other was originally located in the ethmoid cells and extended into the maxillary sinus. After reviewing the literature on this subject, the authors analyze the pathogenetic theories and the clinicoradiological expressions. These raise an obvious diagnostic difficulty: the diagnosis is virtually impossible to establish before surgery and a clinicopathological study are performed.
Subject(s)
Cholesteatoma/diagnosis , Ethmoid Sinus , Maxillary Sinus , Paranasal Sinus Diseases/diagnosis , Aged , Cholesteatoma/surgery , Diagnosis, Differential , Female , Humans , Middle Aged , Paranasal Sinus Diseases/surgery , Tomography, X-Ray ComputedABSTRACT
A germinal cells tumor in a male manifested as left supraclavicular mass, without other localisation, is presented. The pathologic anatomy corroborate the diagnosis of seminoma. Very few cases of a germinal cell tumor in the supraclavicular fossa, with a normal testicular exploration, have been reported.
