ABSTRACT
The title compound, C(14)H(11)NS, crystallizes with Z' = 0.75 in the space group C2/m. Two independent molecules are present, one of which lies with all the non-H atoms on a mirror plane, while the other is fourfold disordered across a site of 2/m symmetry. The ordered molecules are stacked such that they enclose continuous channels running along twofold rotation axes, and the disordered molecules are positioned within these channels.
ABSTRACT
A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl)acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively.
Subject(s)
Acrylonitrile , Antifungal Agents , Antineoplastic Agents , Acrylonitrile/analogs & derivatives , Acrylonitrile/chemical synthesis , Acrylonitrile/pharmacology , Antifungal Agents/chemical synthesis , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Humans , Microbial Sensitivity Tests , Mitosporic Fungi/drug effects , Molecular StructureABSTRACT
The structure of (E)-2-(2-thienyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile, C16H15NO3S, contains no direction-specific intermolecular interactions. The molecules of (E)-3-(4-bromophenyl)-2-(2-thienyl)acrylonitrile, C13H8BrNS, exhibit orientational disorder of the thienyl fragment, and the molecules are linked into simple C(5) chains by a single C-H...N hydrogen bond. In (E)-3-phenyl-2-(3-thienyl)acrylonitrile, C13H9NS, the molecules are linked into sheets by a combination of one C-H...N hydrogen bond and one C-H...pi(arene) hydrogen bond.