ABSTRACT
A toxicologic and dermatologic review of 3-phenyl-1-propanol when used as a fragrance ingredient is presented. 3-Phenyl-1-propanol is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta-oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenyl-1-propanol was evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, in vitro skin absorption and mutagenicity. A safety assessment of all cinnamyl phenylpropyl compounds will be published simultaneously with this document; please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all cinnamyl phenylpropyl materials in fragrances (Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.).
Subject(s)
Perfume/chemistry , Perfume/toxicity , Propanols/chemistry , Propanols/toxicity , Animals , Cinnamates/chemistry , Cinnamates/toxicity , DNA Damage/drug effects , Dermatitis, Allergic Contact/pathology , Dermatitis, Phototoxic/pathology , Eye Injuries/chemically induced , Eye Injuries/pathology , Humans , Mucous Membrane/drug effects , Mucous Membrane/pathology , Odorants , Skin/drug effects , Skin/pathology , Toxicity Tests/methodsABSTRACT
A toxicologic and dermatologic review of 3-phenylpropyl cinnamate when used as a fragrance ingredient is presented. 3-Phenylpropyl cinnamate is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta-oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenylpropyl cinnamate was evaluated then summarized and includes physical properties, acute toxicity, skin irritation and skin sensitization. A safety assessment of all cinnamyl phenylpropyl compounds will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all the cinnamyl phenylpropyl materials in fragrances. Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.
Subject(s)
Cinnamates/chemistry , Cinnamates/toxicity , Perfume/chemistry , Perfume/toxicity , Animals , DNA Damage/drug effects , Dermatitis, Allergic Contact/pathology , Dermatitis, Phototoxic/pathology , Eye Injuries/chemically induced , Eye Injuries/pathology , Humans , Mucous Membrane/drug effects , Mucous Membrane/pathology , Odorants , Pentanols/chemistry , Pentanols/toxicity , Skin/drug effects , Skin/pathology , Toxicity Tests/methodsABSTRACT
A toxicologic and dermatologic review of 3-phenylpropyl isobutyrate when used as a fragrance ingredient is presented. 3-Phenylpropyl isobutyrate is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenylpropyl isobutyrate was evaluated then summarized and includes physical properties, acute toxicity, skin irritation and skin sensitization. A safety assessment of all cinnamyl phenyl propyl compounds will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all cinnamyl phenylpropyl materials in fragrances. Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.
Subject(s)
Cinnamates/chemistry , Cinnamates/toxicity , Isobutyrates/toxicity , Perfume/chemistry , Perfume/toxicity , Animals , DNA Damage/drug effects , Dermatitis, Allergic Contact/pathology , Dermatitis, Phototoxic/pathology , Eye Injuries/chemically induced , Eye Injuries/pathology , Humans , Isobutyrates/chemistry , Odorants , Pentanols/chemistry , Pentanols/toxicity , Skin/drug effects , Skin/pathology , Toxicity TestsSubject(s)
Cinnamates/toxicity , Monoterpenes/toxicity , Mutagens/toxicity , Perfume/toxicity , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Dose-Response Relationship, Drug , Humans , Monoterpenes/classification , Monoterpenes/pharmacokinetics , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin AbsorptionABSTRACT
A toxicologic and dermatologic review of isoamyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Pentanes/toxicity , Perfume/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Pentanes/classification , Pentanes/pharmacokinetics , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of cinnamyl isobutyrate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of cis-3-hexenyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Alkenes/toxicity , Cinnamates/toxicity , Perfume/toxicity , Alkenes/pharmacokinetics , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin Absorption , StereoisomerismABSTRACT
A toxicologic and dermatologic review of cinnamyl benzoate when used as a fragrance ingredient is presented.
Subject(s)
Benzoates/toxicity , Cinnamates/toxicity , Perfume/toxicity , Animals , Benzoates/classification , Benzoates/pharmacokinetics , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of cinnamyl tiglate when used as a fragrance ingredient is presented.
Subject(s)
Alkenes/toxicity , Cinnamates/toxicity , Perfume/toxicity , Alkenes/pharmacokinetics , Animals , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of isobutyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of isopropyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of alpha-methylcinnamic alcohol when used as a fragrance ingredient is presented.
Subject(s)
Butanols/toxicity , Cinnamates/toxicity , Perfume/toxicity , Animals , Butanols/classification , Butanols/pharmacokinetics , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Mutagens/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin TestsABSTRACT
A toxicologic and dermatologic review of alpha-amylcinnamyl alcohol when used as a fragrance ingredient is presented.
Subject(s)
Alcohols/toxicity , Perfume/toxicity , Skin/drug effects , Administration, Cutaneous , Administration, Oral , Alcohols/classification , Alcohols/pharmacokinetics , Allergens/classification , Allergens/pharmacokinetics , Allergens/toxicity , Animals , Consumer Product Safety , Dermatitis, Allergic Contact/etiology , Dermatitis, Allergic Contact/pathology , Humans , Lymph Nodes/drug effects , Lymph Nodes/pathology , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Mutagens/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin TestsABSTRACT
A toxicologic and dermatologic review of cinnamyl isovalerate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Propionates/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Perfume/classification , Perfume/pharmacokinetics , Propionates/classification , Propionates/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity TestsABSTRACT
A toxicologic and dermatologic review of allyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Allyl Compounds/toxicity , Cinnamates/toxicity , Perfume/toxicity , Skin/drug effects , Allyl Compounds/pharmacokinetics , Animals , Cinnamates/pharmacokinetics , Female , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Male , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Mutagens/toxicity , Perfume/classification , Perfume/pharmacokinetics , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin TestsABSTRACT
A toxicologic and dermatologic review of pentyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Skin/drug effects , Administration, Cutaneous , Consumer Product Safety , Humans , Risk Assessment , Skin/metabolism , Skin AbsorptionABSTRACT
A toxicologic and dermatologic review of cinnamyl formate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Valerates/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Dose-Response Relationship, Drug , Humans , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity Tests , Valerates/classification , Valerates/pharmacokineticsABSTRACT
A toxicologic and dermatologic review of methyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Animals , CHO Cells , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Cricetinae , Cricetulus , Dose-Response Relationship, Drug , Humans , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Mutagens/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin Absorption , Skin Irritancy Tests , Skin TestsABSTRACT
A toxicologic and dermatologic review of benzyl cinnamate when used as a fragrance ingredient is presented.
Subject(s)
Benzyl Compounds/toxicity , Cinnamates/toxicity , Perfume/toxicity , Administration, Cutaneous , Allergens/classification , Allergens/pharmacokinetics , Allergens/toxicity , Animals , Benzyl Compounds/classification , Benzyl Compounds/pharmacokinetics , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , In Vitro Techniques , Irritants/classification , Irritants/pharmacokinetics , Irritants/toxicity , Mutagenicity Tests , Mutagens/classification , Mutagens/pharmacokinetics , Mutagens/toxicity , Perfume/classification , Perfume/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin TestsABSTRACT
A toxicologic and dermatologic review of Cinnamyl cinnamate when used as a fragrance ingredient is presented.
