1.
Microb Drug Resist
; 29(9): 388-391, 2023 Sep.
Article
in English
| MEDLINE
| ID: mdl-37222764
ABSTRACT
Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.
Subject(s)
Bacteremia , Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Staphylococcus capitis , Infant, Newborn , Humans , Linezolid/pharmacology , Linezolid/therapeutic use , Anti-Bacterial Agents/pharmacology , Staphylococcal Infections/drug therapy , Coagulase/genetics , Microbial Sensitivity Tests , Staphylococcus/genetics , Bacteremia/drug therapy , Genomics , Hospitals
2.
J Glob Antimicrob Resist
; 32: 48-49, 2023 03.
Article
in English
| MEDLINE
| ID: mdl-36587793