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Res Vet Sci ; 105: 160-4, 2016 Apr.
Article in English | MEDLINE | ID: mdl-27033926

ABSTRACT

The purpose of this study was to evaluate the pharmacokinetics of moxidectin in alpacas after single subcutaneous injection of a non-aqueous formulation or oral administration of an aqueous drench at 0.2 mg∗kg(-1). Plasma moxidectin concentrations were measured with reverse phase HPLC, and data analyzed using non-compartmental methods. Half-life was longer (p=0.02) after subcutaneous administration than oral (292+/-170 vs 33+/-39 h). The area under the concentration-time curve was greater (p=0.04) following subcutaneous administration (1484.8+/-1049.5 h∗ng∗ml(-1)) than oral (157.6+/-85.9 h∗ng∗ml(-1)). The peak concentration (Cmax) was higher and the after subcutaneous administration, but the difference was not statistically significant (p=0.18). The relative bioavailability of the oral moxidectin to the subcutaneous moxidectin was 11%. The data suggest a higher relative bioavailability following subcutaneous compared to oral administration. Further studies are needed to determine the therapeutic concentrations of moxidectin in alpacas.


Subject(s)
Antinematodal Agents/pharmacokinetics , Camelids, New World , Haemonchiasis/veterinary , Haemonchus/drug effects , Macrolides/pharmacokinetics , Administration, Oral , Animals , Antinematodal Agents/administration & dosage , Biological Availability , Chromatography, High Pressure Liquid/veterinary , Haemonchiasis/drug therapy , Haemonchiasis/parasitology , Half-Life , Injections, Subcutaneous/veterinary , Macrolides/administration & dosage , Male
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