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1.
Res Dev Disabil ; 146: 104689, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38310732

ABSTRACT

BACKGROUND: People with intellectual disabilities often need assistance of some kind in their everyday life. Support needs can increase the risk of their victimization at the hands of professional and family caregivers. This paper explores the differences in caregiver victimization between participants living in residential care settings and those who are not. METHOD: A sample of 260 adults (59.2 % men) with an intellectual disability diagnosis were assessed using an adaptation of the Juvenile Victimization Questionnaire comparing prevalence, sum and variety scores. RESULTS: More than half of the sample (59.2 %) experienced some form of caregiver victimization throughout their lifetime, with physical abuse, verbal abuse, and neglect being the most frequently reported forms. Participants in residential care settings experienced significantly more caregiver victimization incidents and a broader range of victimization forms than their counterparts outside residential care. Significant differences were found based on the individuals' place of residence and gender. Details are provided on the last victimization incident, the perpetrator, the psychological and physical consequences of the victimization, and the reporting rates. CONCLUSIONS: This study outlines high rates of lifetime caregiver victimization, with those who live in residential care settings at particular risk. Further research is needed to gain a deeper understanding of the nuances of caregiver victimization and to prevent abuse in caregiving contexts.


Subject(s)
Bullying , Crime Victims , Intellectual Disability , Adult , Male , Humans , Female , Caregivers , Intellectual Disability/epidemiology , Hand , Upper Extremity
2.
Disabil Health J ; 17(2): 101573, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38072748

ABSTRACT

BACKGROUND: Research has shown high rates of victimization among people with intellectual disabilities (ID), but victimization clusters have been barely explored. OBJECTIVE: We address the gap by examining how reported victimization experiences are grouped into different classes and identifying differences in the characteristics of the individuals in each class. METHODS: We conducted a cross-sectional self-report study with a sample of adults with an ID diagnosis (n = 260). We gathered data about the participants' victimization experiences and socio-demographics, and then subjected the data to latent class analysis (LCA). RESULTS: Three different classes were detected: High victimization (n = 27, 10.4 %); medium victimization, low sexual (n = 97, 37.3 %); and low victimization (n = 136, 52.3 %). The results highlight the experiences of sexual and physical victimization among the high-victimization class, in which women are overrepresented, and physical victimization among the medium-victimization class. The study also found that experiences of assault and bias attacks occur to a varying extent across all three classes. The LCA and poly-victimization methods showed substantial agreement but also differences when identifying the most victimized participants. In addition, we detected significant differences between classes in gender, type of school attended, place of residence, legal incapacity, type of support needed, secondary disability and poly-victimization status. CONCLUSION: We identified distinct underlying ingroup patterns of victimization and sociodemographic inter-class differences that contribute to a better understanding of victimization within the population in question. The results have prevention and intervention implications for caregivers and providers of services for people with ID.


Subject(s)
Crime Victims , Disabled Persons , Intellectual Disability , Adult , Humans , Female , Latent Class Analysis , Cross-Sectional Studies
4.
Pediatrics ; 151(Suppl 2)2023 05 01.
Article in English | MEDLINE | ID: mdl-37125881

ABSTRACT

OBJECTIVES: To assess impact and implementation of remote delivery of a parenting program following suspension of in-person visits during the coronavirus disease 2019 pandemic. METHODS: Impact of remote delivery of the Reach Up parenting program on parenting practices was evaluated by randomized trial in Jamaica. Mothers with children aged 5 to 24 months who met 1 of 7 at-risk criteria were enrolled at health centers. Participants were randomly assigned to intervention or control using random number tables generated by a statistician. Intervention comprised a manual for parents with illustrated play activities, phone calls, and short message service messages. The control group received usual care. Parent practices were measured using an adapted Family Care Indicators telephone-administered questionnaire by interviewers unaware of group assignment. Qualitative interviews were conducted with staff and parents in Jamaica and Brazil and staff in Ecuador to identify facilitators and barriers to remote delivery of Reach Up. RESULTS: Two hundred forty-seven participants were assessed at endline (control n = 130; intervention n = 117). Intervention increased parent activities that support child development, effect size 0.34 SD (95% confidence interval 0.03-0.53), and use of praise, odds 2 times higher with intervention. There were no benefits to interactive language or play materials. Qualitative results showed parents appreciated program continuation and felt motivated to help their child, and methods were acceptable to staff. Barriers included poor mobile phone access, difficulty contacting parents, and feedback limitations without in-person contact. CONCLUSIONS: Remote delivery methods have potential to contribute to scaling of parenting programs.


Subject(s)
COVID-19 , Parenting , Child , Female , Humans , Parents , Mothers , Child Development
5.
Pediatrics ; 151(Suppl 2)2023 05 01.
Article in English | MEDLINE | ID: mdl-37125892

ABSTRACT

BACKGROUND AND OBJECTIVES: Evidence is needed on effective approaches to build parents' ability to promote child development feasible in low- and middle-income countries. Our objective was to synthesize impact of the Reach Up early childhood parenting program in several low- and middle-income countries and examine moderation by family and implementation characteristics. METHODS: Systematic search using PubMed and Academic Search Elite/EBSCO Host. Randomized controlled trials of the Reach Up program from 1985 to February 2022 were selected. Data were extracted by 2 independent researchers. Primary outcomes were child cognitive, language, and motor development. Secondary outcomes were home stimulation and maternal depressive symptoms. We synthesized pooled effect sizes using random effect inverse-variance weighting and effect modification by testing pooled subgroup effect estimates using the χ2 test for heterogeneity. RESULTS: Average effect size across 18 studies ranged from 0.49 (95% confidence interval [CI] 0.32 to 0.66) for cognition, 0.38 (CI 0.24 to 0.51) for language, 0.27 (CI 0.13 to 0.40) for motor development, 0.37 (CI 0.21 to 0.54) for home stimulation, and -0.09 (CI -0.19 to 0.01) for maternal depressive symptoms. Impacts were larger in studies targeted to undernourished children, with mean enrollment older than age 12 months and intervention duration 6 to 12 months. Quality of evidence assessed with the Cochrane Assessment of Risk of Bias and GRADE system was moderate. Instruments used to assess child development varied. In moderator analyses, some subgroups included few studies. CONCLUSIONS: Reach Up benefits child development and home stimulation and is adaptable across cultures and delivery methods. Child and implementation characteristics modified the effects, with implications for scaling.


Subject(s)
Child Development , Parenting , Child , Child, Preschool , Humans , Infant , Depression/diagnosis , Parents , Cognition
6.
J Interpers Violence ; 38(15-16): 9423-9437, 2023 08.
Article in English | MEDLINE | ID: mdl-37029722

ABSTRACT

Research has drawn attention to the stigma and high rates of victimization among people with intellectual disabilities (ID) and an overlap between bias and non-bias victimization. However, studies of bias events or hate crime involving persons with ID are scarce. Using a self-report measure, we analyze lifetime bias victimization in a sample of 260 adults diagnosed with ID (age M = 41.7, SD = 12.0; 59.2% men), of whom 92 experienced bias victimization (age M = 41.2, SD = 11.9; 54.3% men), and compare the number of different types of victimization and the poly-victimization status between bias and non-bias victims. We also examine the following features: the victim, offender(s), victim-offender relationship, and location. Results show that bias victims experience a higher number of different types of victimization than non-bias victims (M = 7.74 and 4.96, respectively; p <.001, rrb=.37, ξ=.42) and are four times more likely to be poly-victims than non-bias victims (odds ratio [OR] = 4.37; 95% CI, p <.001). Most of the victims experienced a number of bias victimization episodes (89.1%; n = 82), and more than a quarter were injured (27.2%, n = 25) as a result of the victimization. All the bias victimizations by strangers were carried out in public places, as were most of the bias victimizations by acquaintances. Schoolmates and work colleagues perpetrated attacks at school and in the workplace, respectively. More than half of the victims, 63% (n = 58), spoke of the experience with someone, but only one reported it to the authorities. The paper provides a valuable descriptive and bivariate analysis of bias victimization of people with ID. The findings will help to understand bias violence against this population, highlighting the need for targeted and effective interventions.


Subject(s)
Crime Victims , Intellectual Disability , Male , Adult , Humans , Female , Intellectual Disability/epidemiology , Violence , Crime , Self Report
7.
BMJ Glob Health ; 8(1)2023 01.
Article in English | MEDLINE | ID: mdl-36650017

ABSTRACT

INTRODUCTION: With the ratification of the Sustainable Development Goals, there is an increased emphasis on early childhood development (ECD) and well-being. The WHO led Global Scales for Early Development (GSED) project aims to provide population and programmatic level measures of ECD for 0-3 years that are valid, reliable and have psychometrically stable performance across geographical, cultural and language contexts. This paper reports on the creation of two measures: (1) the GSED Short Form (GSED-SF)-a caregiver reported measure for population-evaluation-self-administered with no training required and (2) the GSED Long Form (GSED-LF)-a directly administered/observed measure for programmatic evaluation-administered by a trained professional. METHODS: We selected 807 psychometrically best-performing items using a Rasch measurement model from an ECD measurement databank which comprised 66 075 children assessed on 2211 items from 18 ECD measures in 32 countries. From 766 of these items, in-depth subject matter expert judgements were gathered to inform final item selection. Specifically collected were data on (1) conceptual matches between pairs of items originating from different measures, (2) developmental domain(s) measured by each item and (3) perceptions of feasibility of administration of each item in diverse contexts. Prototypes were finalised through a combination of psychometric performance evaluation and expert consensus to optimally identify items. RESULTS: We created the GSED-SF (139 items) and GSED-LF (157 items) for tablet-based and paper-based assessments, with an optimal set of items that fit the Rasch model, met subject matter expert criteria, avoided conceptual overlap, covered multiple domains of child development and were feasible to implement across diverse settings. CONCLUSIONS: State-of-the-art quantitative and qualitative procedures were used to select of theoretically relevant and globally feasible items representing child development for children aged 0-3 years. GSED-SF and GSED-LF will be piloted and validated in children across diverse cultural, demographic, social and language contexts for global use.


Subject(s)
Big Data , Judgment , Humans , Child , Child, Preschool , Surveys and Questionnaires , Child Development , Psychometrics
8.
BMJ Open ; 13(1): e062562, 2023 01 24.
Article in English | MEDLINE | ID: mdl-36693690

ABSTRACT

INTRODUCTION: Children's early development is affected by caregiving experiences, with lifelong health and well-being implications. Governments and civil societies need population-based measures to monitor children's early development and ensure that children receive the care needed to thrive. To this end, the WHO developed the Global Scales for Early Development (GSED) to measure children's early development up to 3 years of age. The GSED includes three measures for population and programmatic level measurement: (1) short form (SF) (caregiver report), (2) long form (LF) (direct administration) and (3) psychosocial form (PF) (caregiver report). The primary aim of this protocol is to validate the GSED SF and LF. Secondary aims are to create preliminary reference scores for the GSED SF and LF, validate an adaptive testing algorithm and assess the feasibility and preliminary validity of the GSED PF. METHODS AND ANALYSIS: We will conduct the validation in seven countries (Bangladesh, Brazil, Côte d'Ivoire, Pakistan, The Netherlands, People's Republic of China, United Republic of Tanzania), varying in geography, language, culture and income through a 1-year prospective design, combining cross-sectional and longitudinal methods with 1248 children per site, stratified by age and sex. The GSED generates an innovative common metric (Developmental Score: D-score) using the Rasch model and a Development for Age Z-score (DAZ). We will evaluate six psychometric properties of the GSED SF and LF: concurrent validity, predictive validity at 6 months, convergent and discriminant validity, and test-retest and inter-rater reliability. We will evaluate measurement invariance by comparing differential item functioning and differential test functioning across sites. ETHICS AND DISSEMINATION: This study has received ethical approval from the WHO (protocol GSED validation 004583 20.04.2020) and approval in each site. Study results will be disseminated through webinars and publications from WHO, international organisations, academic journals and conference proceedings. REGISTRATION DETAILS: Open Science Framework https://osf.io/ on 19 November 2021 (DOI 10.17605/OSF.IO/KX5T7; identifier: osf-registrations-kx5t7-v1).


Subject(s)
Caregivers , Language , Humans , Child , Child, Preschool , Reproducibility of Results , Cross-Sectional Studies , Surveys and Questionnaires , Psychometrics/methods
9.
J Eur Econ Assoc ; 20(4): 1395-1432, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35965610

ABSTRACT

Early childhood development is becoming the focus of policy worldwide. However, the evidence on the effectiveness of scalable models is scant, particularly when it comes to infants in developing countries. In this paper, we describe and evaluate with a cluster-Randomized Controlled Trial an intervention designed to improve the quality of child stimulation within the context of an existing parenting program in Colombia, known as FAMI. The intervention improved children's development by 0.16 of a standard deviation (SD) and children's nutritional status, as reflected in a reduction of 5.8 percentage points of children whose height-for-age is below -1 SD.

10.
J Interpers Violence ; 37(15-16): NP14117-NP14139, 2022 08.
Article in English | MEDLINE | ID: mdl-33866835

ABSTRACT

This study examines the prevalence and characteristics of sexual victimization experiences suffered by people with intellectual disabilities (ID). The sample consisted of 260 adults with an ID diagnosis (154 men and 106 women), ranging in age from 20 to 71 years (M = 41.69, SD = 12.05). The results showed that 35% of the sample had been sexually victimized at some point in their life. Being a woman, being declared legally incapable, and having comorbid mental health diagnoses were the most relevant characteristics of sexual victims with ID. Fondling was the most reported victimization, and rape showed the greatest gender differences, with a higher risk for women with ID of being raped compared to their male counterparts (odds ratio = 4.28, p < .05). The offender was generally a known male adult, and the percentage of incidents reported to the authorities was very low (7.4%). The psychological consequences of abuse were general distress, anxiety, and depressive symptomatology. Intervention and prevention programs targeting this population, as well as the training of professionals and caregivers, are essential to deal with sexual victimization and to protect and ensure the quality of life of people with ID.


Subject(s)
Crime Victims , Intellectual Disability , Adult , Aged , Crime Victims/psychology , Female , Humans , Intellectual Disability/epidemiology , Male , Middle Aged , Prevalence , Quality of Life , Sexual Behavior , Young Adult
11.
J Interpers Violence ; 37(5-6): 2062-2082, 2022 03.
Article in English | MEDLINE | ID: mdl-32627719

ABSTRACT

People with intellectual disabilities appear to be more vulnerable to victimization. However, few studies have assessed victimization in these groups and those that do exist are highly heterogeneous and tend to focus only on specific forms of violence. This study attempts to shed light on the phenomenon of victimization among adults with intellectual disabilities by assessing victimization and poly-victimization throughout their life course. The sample consisted of 260 adults (154 men and 106 women) with an intellectual disability diagnosis, recruited from the Catalan Federation for People with Intellectual Disabilities (DINCAT) in Spain. They ranged in age from 20 to 71 years (M = 41.69, SD = 12.05). Victimization experiences were assessed by means of an adaptation of the retrospective version of the Juvenile Victimization Questionnaire (JVQ). The results showed that 96.9% of the participants had suffered some kind of victimization throughout their lives. With respect to the types of victimization, the most frequent were common victimization (87.7%), witnessing and indirect victimization (67.3%), victimization by caregivers (59.2%), sexual victimization (35%), and electronic victimization (23.5%). Women and early adults tended to experience higher rates of victimization. The poly-victimized group experienced 13 or more incidents of victimization throughout their lives. This study highlights the elevated rates of lifetime victimization among people with intellectual disabilities. It adds to previous evidence that special protection programs are required to address this issue and emphasizes the need for prevention and intervention measures in this particularly vulnerable group.


Subject(s)
Bullying , Crime Victims , Intellectual Disability , Adult , Aged , Female , Humans , Intellectual Disability/epidemiology , Male , Middle Aged , Retrospective Studies , Surveys and Questionnaires , Young Adult
12.
Pap. psicol ; 42(3): 193-199, Septiembre, 2021. tab
Article in Spanish | IBECS | ID: ibc-225248

ABSTRACT

La explotación sexual comercial infantil y adolescente (ESCIA) es un problema especialmente frecuente en niños, niñas y adolescentes con medidas jurídicas de protección. Esta forma de victimización sexual, que recoge otras múltiples formas de violencia, no sólo está presente en países envías de desarrollo. En España, únicamente contamos con los datos obtenidos por la Comisión de Expertos de Mallorca en 2020. Se presentan las respuestas de 67 adolescentes, entre 13 y 18 años, en centros residenciales del sistema de protección, sobre sus conocimientos y experiencias respecto a la ESCIA. Los resultados indican que se trata de un problema conocido y ante el cual demandan más educación y protección. Aluden a motivos diversos para implicarse en él, pero todos ellos pueden situarse dentro de la pirámide del sexo por supervivencia. El uso de las TIC aparece como un importante factor de riesgo a tener en cuenta en programas de prevención. (AU)


Commercial sexual exploitation of children (CSEC) is a problem that is highly prevalent in children and adolescents under legal protection. However, thisform of sexual victimization, which includes multiple other forms of violence, is not only present in developing countries. In Spain we only have the data obtained by the Expert Commission from Mallorca in 2020. The responses of a sample of 67 adolescents between 13 and 18 years old from residentialcenters in Mallorca about their knowledge and experiences regarding CSEC are presented. The results indicate that CSEC is a known problem. These adolescents also demand more education and protection. They allude to various reasons for engaging in this type of behavior, although all of them canbe placed in the pyramid of survival sex. The use of ICT appears as an important risk factor to take into account in prevention programs. (AU)


Subject(s)
Humans , Male , Female , Adolescent , Sex Offenses/psychology , Child Abuse, Sexual/prevention & control , Child Abuse, Sexual/psychology , Sexual Harassment/psychology , Sexual Vulnerability , Spain , Residential Facilities/ethics
13.
Pediatr. catalan ; 81(2): 63-70, Abril - Juny 2021. tab, graf
Article in Catalan | IBECS | ID: ibc-218055

ABSTRACT

L’objectiu d’aquest treball és analitzar l’evolució de la demanda assistencial i les possibilitats diagnòstiques, en laconsulta de genètica clínica d’un hospital de tercer nivell durant els últims cinquanta anys i també a partir dels seus inicis com a consulta específica de Pediatria.S’hi analitzen tant els motius de consulta com les proves de laboratori disponibles per arribar al diagnòstic dels pacients valorats durant el període 1968-2018, a la consulta de Genètica Clínica i al Laboratori de Genètica. A partir de 200 consultes anuals, en els primers anys, arribem a l’actualitat, en què se’n fan al voltant de 8.000 (entre primeres, successives i interconsultes), distribuïdes en Genètica Clínica i Assessorament Genètic, fins a un total de més de 32.000 pacients visitats durant aquests cinquanta anys.Al Laboratori de Genètica, l’evolució abasta des de l’estudi del cariotip convencional fins a l’aplicació de les tecnologies genòmiques actuals, i s’hi fan més de 9.000 estudis anuals de pacients de l’Hospital. Amb la incorporació de noves tecnologies moleculars s’ha canviat el paradigma de l’estudi genètic i s’ha aconseguit un rendiment millor: s’han pogut incrementar els diagnòstics i també s’ha reduït el temps necessari per obtenir-los.A més de la transformació del genetista que col·labora en el seguiment multidisciplinari dels pacients, s’evidencia uncanvi i una diversificació del motiu de consulta i s’estableix el valor de la incorporació, a partir del 2010, de professionals especialitzats en assessorament genètic per donar resposta a aquesta demanda.Els canvis experimentats en els motius de consulta, els diagnòstics i les proves de laboratori fetes durant tots aquests anys reflecteixen la importància de la incorporació i la interacció, en una mateixa àrea o unitat assistencial, de professionals especialitzats en genètica clínica, assessorament genètic i laboratori de genètica integral (també ambbioinformàtics). (AU)


El objetivo de este trabajo es analizar la evolución de la demandaasistencial y las posibilidades diagnósticas en la consulta de genética clínica de un hospital de tercer nivel a lo largo de los últimos50 años a partir de sus inicios como una consulta específica dePediatría.Se analizan los motivos de consulta y las pruebas de laboratorio disponibles para llegar al diagnóstico de los pacientes valorados en el período 1968-2018 en la Consulta de Genética Clínica y el Laboratorio de Genética. A partir de 200 consultas anuales en los primeros años llegamos a la actualidad, en que se realizan alrededor de 8.000 visitas (primeras, sucesivas e interconsultas) distribuidas en Genética Clínica y Asesoramiento Genético (32.000pacientes visitados hasta la fecha).En el laboratorio de Genética la evolución abarca desde el estudio del cariotipo convencional hasta la aplicación de las tecnologías genómicas actuales realizando más de 9.000 estudios anuales de pacientes del Hospital. Además de la transformación del genetista clínico colaborando en el seguimiento multidisciplinar de los pacientes, se evidencia un cambio y diversificación del motivo de consulta y se establece el valor de la incorporación de profesionales especializados en asesoramiento genético (a partir de 2010) para dar respuesta a esta demanda. Con la incorporación de nuevas tecnologías moleculares se ha cambiado el paradigma del estudio genético con un incremento importante del rendimiento y mejoría en el tiempo en obtener resultados diagnósticos. Los cambios experimentados en los motivos de consulta, los diagnósticos y las pruebas de laboratorio realizadas a lo largo de estos años reflejan la importancia de la incorporación e interacción, en una misma área/unidad asistencial, de profesionales especializados en genética clínica, asesores genéticos y laboratorio de genética integral (incluyendo bioinformáticos). (AU)


The objective of this work is to analyze the evolution of the demand and the diagnostic capabilities in the clinical genetics service of a tertiary hospital over the last 50 years from its initiationas a specific pediatric consultation. The reasons for consultationare analyzed as well as the laboratory tests available to reach thediagnosis of the patients evaluated in the period 1968-2018 at the Clinical Genetics Service and the Genetics Laboratory. From 200 consultations/year in the first years, we have reachedaround 8,000 visits (first, follow-up, and internal consultations) distributed in Clinical Genetics and Genetic Counseling (32,000patients visited to date).The Genetics Laboratory evolved from the study of the conventional karyotype to the application of state of the art genomic technologies, carrying out more than 9,000 annual studies from patients followed–up in the hospital.In addition to the transformation of the role of the clinical geneticist into a member of the multidisciplinary care team, there isevidence of a change and diversification of the reasons for consultation and in the value of incorporating professionals specializedin genetic counseling (starting in 2010) to respond to this demand. With the incorporation of new molecular technologies, theparadigm of the genetic study has changed, with a significant increase in performance and improving time to diagnostic results.The changes experienced in the reasons for consultation, diagnosesand laboratory tests carried out throughout these years reflect theimportance of the incorporation and interaction, in the same healthcare area or unit, of professionals specialized in clinical geneticsand genetic counseling, with a comprehensive genetics laboratory(including bioinformatics). (AU)


Subject(s)
Humans , Child , History, 20th Century , History, 21st Century , Genetic Counseling/history , Genetic Counseling/trends , Genetics/history , Pediatrics
14.
Ann N Y Acad Sci ; 1492(1): 58-72, 2021 05.
Article in English | MEDLINE | ID: mdl-33378099

ABSTRACT

Although many education and health programs aim to improve early childhood development, it is challenging to assess developmental levels of infants and small children through large household surveys. The Caregiver Reported Early Development Instruments (CREDI) has been proposed as an adaptable, practical, and low-cost instrument for measuring the developmental status of children under 3 years of age at scale, as it is relatively short and collected by caregiver report. This study employed the CREDI to measure the development of a sample of 994 children ages 22-35 months in rural India and compared the results to those obtained using the Bayley Scales of Infant and Toddler Development (Bayley-III), a reliable and widely used instrument, albeit one not always suited to large-scale data collection efforts given its length, cost, and complexity of administration. The CREDI validation exercise showed that caregivers can provide assessments in keeping with the more interactive (hence more time-consuming and training-intensive) Bayley-III instrument. Noteworthy, there was no indication that concordance of the instruments differed by education of the caregiver. This is important as it points to alternate feasible tools to measure child development outcomes through large-scale surveys.


Subject(s)
Caregivers , Child Development , Surveys and Questionnaires , Child, Preschool , Female , Humans , India , Infant , Male , Reproducibility of Results , Rural Population , Socioeconomic Factors , Statistics, Nonparametric , Surveys and Questionnaires/statistics & numerical data
15.
Pediatrics ; 146(6)2020 12.
Article in English | MEDLINE | ID: mdl-33148771

ABSTRACT

OBJECTIVES: Poor early childhood development in low- and middle-income countries is a major public health problem. Efficacy trials have shown the potential of early childhood development interventions but scaling up is costly and challenging. Guidance on effective interventions' delivery is needed. In an open-label cluster-randomized control trial, we compared the effectiveness of weekly home visits and weekly mother-child group sessions. Both included nutritional education, whose effectiveness was tested separately. METHODS: In Odisha, India, 192 villages were randomly assigned to control, nutritional education, nutritional education and home visiting, or nutritional education and group sessions. Mothers with children aged 7 to 16 months were enrolled (n = 1449). Trained local women ran the two-year interventions, which comprised demonstrations and interactions and targeted improved play and nutrition. Primary outcomes, measured at baseline, midline (12 months), and endline (24 months), were child cognition, language, motor development, growth and morbidity. RESULTS: Home visiting and group sessions had similar positive average (intention-to-treat) impacts on cognition (home visiting: 0.324 SD, 95% confidence interval [CI]: 0.152 to 0.496, P = .001; group sessions: 0.281 SD, 95% CI: 0.100 to 0.463, P = .007) and language (home visiting: 0.239 SD, 95% CI: 0.072 to 0.407, P = .009; group sessions: 0.302 SD, 95% CI: 0.136 to 0.468, P = .001). Most benefits occurred in the first year. Nutrition-education had no benefit. There were no consistent effects on any other primary outcomes. CONCLUSIONS: Group sessions cost $38 per child per year and were as effective on average as home visiting, which cost $135, implying an increase by a factor of 3.5 in the returns to investment with group sessions, offering a more scalable model. Impacts materialize in the first year, having important design implications.


Subject(s)
Child Development , Counseling/methods , Health Education/methods , House Calls/statistics & numerical data , Mothers/education , Nutritional Status , Child , Female , Humans , India , Male
16.
Am J Med Genet A ; 182(11): 2742-2745, 2020 11.
Article in English | MEDLINE | ID: mdl-32896090

ABSTRACT

Cerebellofaciodental syndrome (MIM #616202) is an autosomal recessive condition characterized by intellectual disability, microcephaly, cerebellar hypoplasia, dysmorphic features, and short stature. To date, eight patients carrying biallelic BRF1 variants have been reported. Here, we describe two siblings with congenital microcephaly and corpus callosum hypoplasia, pre and postnatal growth retardation, congenital heart defect and severe global developmental delay. We also detected additional findings not previously reported in this syndrome, including bilateral sensorineural hearing impairment and inner ear malformation. Whole exome sequencing identified a novel homozygous missense variant (c.654G>C, p.[Trp218Cys]) in BRF1, predicted to affect the protein structure. Expression assessment showed extremely low BRF1 protein expression caused by the identified variant, supporting its causal involvement. The description of new patients with cerebellofaciodental syndrome is essential to better delineate the phenotypic and genotypic spectrum of the disease.


Subject(s)
Abnormalities, Multiple/pathology , Cerebellum/abnormalities , Craniofacial Abnormalities/pathology , Dwarfism/pathology , Intellectual Disability/pathology , Muscular Atrophy/pathology , Mutation , Nervous System Malformations/pathology , Phenotype , TATA-Binding Protein Associated Factors/genetics , Abnormalities, Multiple/genetics , Cerebellum/pathology , Child , Craniofacial Abnormalities/genetics , Developmental Disabilities/genetics , Developmental Disabilities/pathology , Dwarfism/genetics , Humans , Infant , Intellectual Disability/genetics , Male , Muscular Atrophy/genetics , Nervous System Malformations/genetics , Siblings , Exome Sequencing
17.
PLoS One ; 15(4): e0231317, 2020.
Article in English | MEDLINE | ID: mdl-32348359

ABSTRACT

There is increasing global commitment to establish early childhood interventions that promote the development of the millions of disadvantaged children in low- and middle-income countries not reaching their developmental potential. However, progress is hindered by the lack of valid developmental tests feasible for use at large scale. Consequently, there is an urgent need for such tests. Whilst screeners and single-domain tests ('short tests') are used as alternatives, their predictive validity in these circumstances is unknown. A longitudinal study in Bogota, Colombia began in 2011 when 1,311 children ages 6-42 months were given the Bayley Scales of Infant and Toddler Development (Bayley-III) by psychologists and randomized to receive one of two batteries of short tests under survey conditions. Concurrent validity of the short tests with the Bayley-III ('gold standard') was reported. In 2016, at 6-8 years, 940 of these children were given tests of IQ (Wechsler Intelligence Scale for Children, WISC-V) and school achievement (arithmetic, reading, and vocabulary) by psychologists. We compared the ability of the short tests, the Family Care Indicators (FCI), height-for-age, stunting (median height-for-age <-2 SD), and the Bayley-III to predict IQ and achievement in middle childhood. Predictive validity increased with age for all tests, and cognition and language were usually the highest scales. At 6-18 months, all tests had trivial predictive ability. Thereafter, the Bayley-III had the highest predictive validity, but the Denver Developmental Screening Test was the most feasible and valid short test and could be used with little validity loss compared with the Bayley-III. The MacArthur-Bates Communicative Development Inventory at 19-30 months and the FCI under 31 months predicted IQ and school achievement as well as the Bayley-III. The FCI had higher predictive validity than stunting and height-for-age, and could be added to stunting for use as a population-based indicator of child development.


Subject(s)
Child Development , Neuropsychological Tests , Child , Child, Preschool , Cognition , Colombia , Female , Humans , Infant , Longitudinal Studies , Male , Surveys and Questionnaires
18.
Article in Spanish | IBECS | ID: ibc-202079

ABSTRACT

Este estudio busca analizar la relación entre la polivictimización, los factores de resiliencia y las conductas suicidas (ideación suicida y/o comportamiento de autolesión) en un grupo de 227 (145 varones y 82 mujeres) adolescentes atendidos por el sistema de protección y justicia juvenil español. Con edades comprendidas entre los 12 y los 17 años (M = 15,26; DT = 1,54). Los resultados indicaron que un 39,6 % de los adolescentes informaron haber presentado conductas suicidas de algún tipo en los últimos seis meses. Se hallaron diferencias en cuanto al tipo de centro, a la edad y al género. La polivictimización fue un predictor significativo de las conductas suicidas, y los factores de resiliencia asociados al individuo contribuyen a reducir el riesgo de conductas suicidas


This study aims at analysing the relationship between poly-victimization, resilience factors and suicidal behaviour (suicidal ideation and/or self-injurious behaviour) in a group of 227 teenagers (145 Male and 82 Female), assisted by the Spanish juvenile protection and justice system. They were aged between 12 and 17 (M = 15,26; TD = 1,54). The results indicated that 39.6 % of the adolescents had reported having had some kind of suicidal behaviour in the last six months. We noticed differences depending on their reception centre, their age and gender. Poly-victimization was a significant predictor of suicidal behaviour. The resilience factors contribute to reducing the risk of suicidal behaviour


Aquest estudi busca analitzar la relació entre la polivictimització, els factors de resiliència I les conductes suïcides (ideació suïcida I / o comportament d'autolesió) en un grup de 227 (145 homes I 82 dones) adolescents atesos pel sistema de protecció I justícia juvenil espanyol, amb edats compreses entre els 12 I els 17 anys (M = 15,26; DT = 1,54). Els resultats van indicar que un 39,6 % dels adolescents van informar haver presentat conductes suïcides d'algun tipus en els últims sis mesos. Es van trobar diferències quant al tipus de centre, a l'edat I al gènere. La polivictimització va ser un predictor significatiu de les conductes suïcides, I els factors de resiliència associats a l'individu contribueixen a reduir-ne el risc


Subject(s)
Humans , Male , Female , Child , Adolescent , Suicidal Ideation , Adolescent Behavior/psychology , Crime Victims/psychology , Resilience, Psychological , Surveys and Questionnaires , Socioeconomic Factors , Cross-Sectional Studies , Risk Factors , Sex Factors , Spain
19.
J Child Psychol Psychiatry ; 61(6): 644-652, 2020 06.
Article in English | MEDLINE | ID: mdl-31797385

ABSTRACT

BACKGROUND: An estimated 63.4 million Indian children under 5 years are at risk of poor development. Home visits that use a structured curriculum to help caregivers enhance the quality of the home stimulation environment improve developmental outcomes. However, achieving effectiveness in poor urban contexts through scalable models remains challenging. METHODS: Using a cluster randomised controlled trial, we evaluated a psychosocial stimulation intervention, comprising weekly home visits for 18 months, in urban slums of Cuttack, Odisha, India. The intervention is complementary to existing early childhood services in India and was run and managed through a local branch of a national NGO. The study ran from August 2013 to July 2015. We enrolled 421 children aged 10-20 months from 54 slums. Slums were randomised to intervention or control. Primary outcomes were children's cognitive, receptive language, expressive language and fine motor development assessed using the Bayley-III. Prespecified intent-to-treat analysis investigated impacts and heterogeneity by gender. TRIAL REGISTRATIONS: ISRCTN89476603, AEARCTR-0000169. RESULTS: Endline data for 378 (89.8%) children were analysed. Attrition was balanced between groups. We found improvements of 0.349 of a standard deviation (SD; p = .005, stepdown p = .017) to cognition while impacts on receptive language, expressive language and fine motor development were, respectively, 0.224 SD (p = .099, stepdown p = .184), 0.192 SD (p = .085, stepdown p = .184) and 0.111 (p = .385, stepdown p = .385). A child development factor improved by 0.301 SD (p = .032). Benefits were larger for boys. The quality of the home stimulation environment also improved. CONCLUSIONS: This study shows that a potentially scalable home-visiting intervention is effective in poor urban areas.


Subject(s)
Child Development , House Calls , Poverty Areas , Urban Population , Cognition , Female , Humans , India , Infant , Male
20.
BMJ Glob Health ; 4(6): e001724, 2019.
Article in English | MEDLINE | ID: mdl-31803508

ABSTRACT

INTRODUCTION: Early childhood development can be described by an underlying latent construct. Global comparisons of children's development are hindered by the lack of a validated metric that is comparable across cultures and contexts, especially for children under age 3 years. We constructed and validated a new metric, the Developmental Score (D-score), using existing data from 16 longitudinal studies. METHODS: Studies had item-level developmental assessment data for children 0-48 months and longitudinal outcomes at ages >4-18 years, including measures of IQ and receptive vocabulary. Existing data from 11 low-income, middle-income and high-income countries were merged for >36 000 children. Item mapping produced 95 'equate groups' of same-skill items across 12 different assessment instruments. A statistical model was built using the Rasch model with item difficulties constrained to be equal in a subset of equate groups, linking instruments to a common scale, the D-score, a continuous metric with interval-scale properties. D-score-for-age z-scores (DAZ) were evaluated for discriminant, concurrent and predictive validity to outcomes in middle childhood to adolescence. RESULTS: Concurrent validity of DAZ with original instruments was strong (average r=0.71), with few exceptions. In approximately 70% of data rounds collected across studies, DAZ discriminated between children above/below cut-points for low birth weight (<2500 g) and stunting (-2 SD below median height-for-age). DAZ increased significantly with maternal education in 55% of data rounds. Predictive correlations of DAZ with outcomes obtained 2-16 years later were generally between 0.20 and 0.40. Correlations equalled or exceeded those obtained with original instruments despite using an average of 55% fewer items to estimate the D-score. CONCLUSION: The D-score metric enables quantitative comparisons of early childhood development across ages and sets the stage for creating simple, low-cost, global-use instruments to facilitate valid cross-national comparisons of early childhood development.

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