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1.
Metabolism of 1,4-androstadiene-3,17-dione by human placental microsomes. Enzyme properties and kinetic parameters in the formation of estrogens and 17 beta-hydroxy-1,4-androstadien-3-one.
Milewich, L; Bradfield, D J; Coe, L D; Masters, B S; MacDonald, P C.
J Steroid Biochem ; 14(11): 1115-25, 1981 Nov.
Article in English | MEDLINE | ID: mdl-7311525

Subject(s)
Androstadienes/metabolism , Estrogens/biosynthesis , Placenta/metabolism , Testosterone/analogs & derivatives , Chemical Phenomena , Chemistry , Female , Humans , In Vitro Techniques , Kinetics , Microsomes/metabolism , NAD/metabolism , NADP/metabolism , Pregnancy , Testosterone/biosynthesis
2.
Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.
Dees, J H; Coe, L D; Yasukochi, Y; Masters, B S.
Science ; 208(4451): 1473-5, 1980 Jun 27.
Article in English | MEDLINE | ID: mdl-6770464

ABSTRACT

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.


Subject(s)
Kidney/enzymology , Liver/enzymology , Lung/enzymology , NADPH-Ferrihemoprotein Reductase/metabolism , Phenobarbital/pharmacology , Animals , Fluorescent Antibody Technique , Kidney/drug effects , Liver/drug effects , Lung/drug effects , Male , Organ Specificity , Rats
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