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Bioorg Med Chem Lett
; 19(22): 6463-6, 2009 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-19811912
ABSTRACT
A prodrug form (17) of a novel C2/C2'-aryl-substituted pyrrolobenzodiazepine (PBD) dimer (16) has been synthesized by introducing sodium bisulfite groups to the C11/C11'-positions of the parent bis-imine. The prodrug form is highly water soluble, stable in aqueous conditions, and the rate of DNA cross-link formation is much slower compared to the parent bis-imine.