Endometrial malignancies arising on endometrial polyps and precursor lesions.

INTRODUCTION: Polyps are covered with endometrial epithelium and composed of varying proportions of gland, stroma, and blood vessels. Traditionally, endometrial polyps are accepted as a precursor of cancer. The aim of this study was to evaluate the relationship between malignancies arising on endometrial polyps and precursor lesions of these malignancies. MATERIALS AND METHODS: Data of patients who underwent total abdominal hysterectomy because of a malignancy diagnosed on endometrial polyps were obtained retrospectively from pathology archives. RESULTS: When all malignancies on endometrial polyp were considered, 37% of cases were Type I, 55% were Type II, and 7% were carcinosarcoma. Endometrial intraepithelial carcinoma (EIC) was detected as tumor-adjacent areas on the polyp in eight of the patients who were diagnosed with serous carcinoma. CONCLUSION: The authors found a precursor lesion in 20 (74%) of their patients who showed endometrial malignancy developing on endometrial polyps. Even when an overt malignancy is not detected on polyps in the curettage material, precursor lesions should be carefully searched.

The effect of endometrial polyps on pregnancy rates in intracytoplasmic spenn injection cycles.

OBJECTIVE: The purpose of this study was to determine reproductive results of intracytoplasmic sperm injection (ICSI) for different endometrial polyps subgroup divided according to polyp size and number. MATERIALS AND METHODS: Eighty-three primer infertile patients were retrospectively analyzed. Group A consisted of 36 patients having an endometrial polyp with a diameter ≤ one cm; whereas 47 patients were included in Group B who had a polyp with a diameter > one cm or more than one polyps. All patients underwent a hysteroscopic polypectomy and ICSI treatments were started in the following cycle. RESULTS: Pregnancy was achieved in 16 patients (44.4%) in Group A and 23 patients (48.9%) in Group B. The pregnancy ratios did not reveal a statistically significant difference between the two groups. CONCLUSION: The authors concluded that in patients who have undergone hysteroscopic polypectomy before the Intracytoplasmic sperm injection (ICSI) cycle, the pregnancy rates do not depend on the diameter of the endometrial polyps.

Does Kruger's strict criteria have prognostic value in predicting ICSI clinical results?

OBJECTIVE: The purpose of this study was to compare clinical results of ICSI for different sperm morphology subgroups divided according to Kruger's classification system. MATERIALS AND METHODS: This retrospectively study was conducted at Zeynep Kamil Training and Researching Hospital in Istanbul (Turkey). The study included 332 intracytoplasmic sperm injection (ICSI) cycles. The patients were under 37 years of age with primary infertility who were admitted to the Department of Reproductive Endocrinology and Infertility, from January 2005 to June 2009. The patients were divided in three groups based on Kruger's strict criteria. Normal sperm morphology was less than 4% in group 1, between 4-14% in group 2, and greater than 14% in group 3. All patients underwent ICSI and embryo transfer (ET) following controlled ovarian hyperstimulation (COH). The groups were compared to the rates of fertilization, implantation, clinical pregnancy, abortion, and live birth. RESULTS: Pregnancy occurred in 132 (39.7%) of all ICSI cycles. There was no statistically significant difference between regarding groups regarding the rates of fertilization, implantation, clinical pregnancy, biochemical pregnancy, abortion, and live birth. CONCLUSION: The authors concluded that the normal sperm morphology defined by Kruger's strict criteria and sperm motility will not be able to predict prognosis of ICSI cycles.