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1.
Eye (Lond) ; 31(8): 1191-1198, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28387764

ABSTRACT

PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups.ResultsLinear mixed model analysis after adjusting for age, sex, and axial length showed that the BMO area was similar in eyes with NAION (1.89±0.33 mm2), their fellow eyes (1.85±0.35 mm2), and control eyes (1.88±0.37 mm2; all P>0.99). Anterior laminar depth was also similar in the three groups. The mean prelaminar tissue thickness of the NAION eyes was 445±176 µm, which was thinner than the prelaminar tissue of their unaffected fellow eyes (mean, 539±227 µm, P=0.004), but both were thicker than the prelaminar tissue of the normal subjects (mean 243±145 µm, P=0.001 and P<0.001, respectively).ConclusionsThe thick prelaminar thickness is associated with unilateral NAION in the affected and unaffected eyes.


Subject(s)
Optic Disk/pathology , Optic Neuropathy, Ischemic/pathology , Adult , Aged , Bruch Membrane/pathology , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Linear Models , Male , Middle Aged , Nerve Fibers/pathology , Prospective Studies , Retinal Ganglion Cells/pathology , Tomography, Optical Coherence/methods , Visual Acuity , Visual Fields
2.
Diabet Med ; 33(1): 84-90, 2016 Jan.
Article in English | MEDLINE | ID: mdl-25981750

ABSTRACT

AIM: Previous studies have reported that monocyte chemoattractant protein-1 (MCP-1) is involved in inflammatory and metabolic diseases. The purpose of this study is to investigate the role of MCP-1 in the pathogenesis of diabetic retinopathy (DR) in Han Chinese patients with Type 2 diabetes. METHODS: Serum levels of MCP-1 protein in patients classified as diabetic without retinopathy (DWR) and DR, including NPDR and PDR, were assayed by enzyme-linked immunosorbent assay. Genomic DNA from 198 DWR patients, 176 NPDR patients and 143 PDR patients were genotyped by using a PCR restriction fragment length polymorphism (PCR-RFLP) assay. RESULTS: MCP-1 serum levels were significantly higher in NPDR and PDR patients than in the DWR patients. The frequencies of the GG genotype and G allele of the single nucleotide polymorphism (SNP) were significantly increased in DR patients compared with DWR patients. Further subgroup analysis was performed to test whether there was an association between the PDR or NPDR and DWR groups. Significantly higher frequencies of the GG genotype and G allele were observed in PDR and NPDR patients compared with DWR patients. Furthermore, the 25 patients with PDR were divided into three groups according to the genotype of the tested SNP. The expression of the MCP-1 gene was higher in the GG genotype group compared with the other two groups. CONCLUSIONS: The results suggested that the -2518 GG genotype and G allele of MCP-1 are associated with an increased risk of PDR in the Chinese Han population. This polymorphism may influence the expression of the MCP-1 gene, which may play an important role in the pathogenesis of DR.


Subject(s)
5' Untranslated Regions , Chemokine CCL2/genetics , Diabetes Mellitus, Type 2/complications , Diabetic Retinopathy/genetics , Genetic Predisposition to Disease , Polymorphism, Single Nucleotide , Up-Regulation , Adult , Alleles , Asian People , Case-Control Studies , Chemokine CCL2/blood , Chemokine CCL2/metabolism , China , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/immunology , Diabetes Mellitus, Type 2/metabolism , Diabetic Retinopathy/blood , Diabetic Retinopathy/immunology , Diabetic Retinopathy/metabolism , Enzyme-Linked Immunosorbent Assay , Female , Gene Expression Regulation , Genetic Association Studies , Hospitals, University , Humans , Male , Middle Aged , Polymorphism, Restriction Fragment Length
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